Motif ID: Irf3

Z-value: 1.028


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_44997700-0.272.2e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_71537402 4.213 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr5_+_114896936 3.590 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr6_-_39118211 3.104 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr4_-_40239779 2.232 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_-_48871408 2.158 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr15_+_32920723 2.034 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr17_+_75178797 2.017 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr17_+_75178911 1.878 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr2_+_122147680 1.835 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr18_-_32559914 1.772 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr11_-_48871344 1.639 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr16_+_35938470 1.553 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr3_+_81932601 1.433 ENSMUST00000029649.2
 Ctso
cathepsin O
chr4_-_40239700 1.398 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_54972603 1.394 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr16_+_35938972 1.389 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr3_+_142560052 1.371 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr3_+_142560108 1.338 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr13_-_23710714 1.216 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr2_-_173276144 1.201 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr7_-_104315455 1.086 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr3_+_142560351 1.046 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr11_+_119393060 1.043 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr16_-_10785525 0.820 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr15_+_79892397 0.811 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr3_+_142530329 0.788 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr13_+_74639866 0.731 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr11_+_58199556 0.722 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr15_+_79892436 0.710 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr2_-_51934644 0.708 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chr9_+_20868628 0.687 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr2_-_51934943 0.648 ENSMUST00000102767.1
ENSMUST00000102768.1
 Rbm43

RNA binding motif protein 43

chr7_-_78578308 0.642 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr14_+_55578123 0.627 ENSMUST00000174484.1
 Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr4_-_156200818 0.547 ENSMUST00000085425.4
 Isg15
ISG15 ubiquitin-like modifier
chrX_+_68678541 0.544 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr2_-_62646146 0.510 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1

chr14_+_55578360 0.508 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
 Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr2_+_167062934 0.503 ENSMUST00000125674.1
 1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr13_+_40859768 0.483 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr19_+_43752996 0.436 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr17_+_21008921 0.426 ENSMUST00000088811.5
 Zfp160
zinc finger protein 160
chr15_-_39112642 0.417 ENSMUST00000022908.8
 Slc25a32
solute carrier family 25, member 32
chr6_-_34317442 0.408 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr19_+_36409719 0.373 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chrX_+_68678624 0.355 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr3_-_151749877 0.354 ENSMUST00000029671.7
 Ifi44
interferon-induced protein 44
chrX_+_68678712 0.313 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr2_-_156857946 0.312 ENSMUST00000099141.2
 4930518I15Rik
RIKEN cDNA 4930518I15 gene
chr7_-_104353328 0.303 ENSMUST00000130139.1
ENSMUST00000059037.8
 Trim12c

tripartite motif-containing 12C

chr17_+_34187545 0.279 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_57358682 0.274 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr17_+_34187789 0.255 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_-_141266415 0.226 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
 Irf7


interferon regulatory factor 7


chr14_+_14012491 0.176 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr2_-_126933229 0.170 ENSMUST00000028844.4
 Sppl2a
signal peptide peptidase like 2A
chr16_-_35871544 0.161 ENSMUST00000042665.8
 Parp14
poly (ADP-ribose) polymerase family, member 14
chr7_-_102565425 0.152 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chr10_-_81496313 0.135 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr5_-_137116177 0.133 ENSMUST00000054384.5
ENSMUST00000152207.1
 Trim56

tripartite motif-containing 56

chr1_+_37890477 0.127 ENSMUST00000027256.5
 Mrpl30
mitochondrial ribosomal protein L30
chr16_-_38341812 0.115 ENSMUST00000114740.2
ENSMUST00000023501.8
 Maats1

MYCBP-associated, testis expressed 1

chr11_-_116027961 0.110 ENSMUST00000106454.1
 H3f3b
H3 histone, family 3B
chr7_-_100514800 0.109 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr10_-_81496329 0.095 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr10_+_83543941 0.080 ENSMUST00000038388.5
 A230046K03Rik
RIKEN cDNA A230046K03 gene
chr2_-_145935014 0.051 ENSMUST00000001818.4
 Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr10_-_87493651 0.042 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr2_+_145934800 0.035 ENSMUST00000138774.1
ENSMUST00000152515.1
ENSMUST00000130168.1
ENSMUST00000133433.1
ENSMUST00000118002.1
 4930529M08Rik




RIKEN cDNA 4930529M08 gene




chr9_-_35176039 0.009 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger

chr14_-_55591077 0.006 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.4 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.9 3.6 GO:0009597 detection of virus(GO:0009597)
0.6 3.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.5 3.8 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.3 4.5 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.3 1.4 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.3 1.5 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.2 1.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 0.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.2 0.5 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.1 3.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.4 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.1 0.5 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 1.0 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.5 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.2 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.1 0.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.7 GO:0042832 defense response to protozoan(GO:0042832)
0.1 1.1 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.0 0.4 GO:0006544 glycine metabolic process(GO:0006544)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.1 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.4 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.7 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 3.3 GO:0051607 defense response to virus(GO:0051607)
0.0 2.0 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.0 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.4 5.3 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.4 1.2 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.3 3.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 1.1 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.1 0.3 GO:1990462 omegasome(GO:1990462)
0.0 3.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 4.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.8 GO:0005770 late endosome(GO:0005770)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.8 GO:0030863 cortical cytoskeleton(GO:0030863)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0050436 microfibril binding(GO:0050436)
0.4 1.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.3 4.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 6.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 1.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 0.7 GO:0050700 CARD domain binding(GO:0050700)
0.2 0.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.2 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.5 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 3.6 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.6 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.7 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 4.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.7 GO:0003924 GTPase activity(GO:0003924)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 7.1 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 2.0 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.8 GO:0001948 glycoprotein binding(GO:0001948)