Motif ID: Irf4

Z-value: 0.708


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 121 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_77894096 3.208 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr8_+_84723003 2.546 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr3_+_90537306 2.240 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr3_+_90537242 2.199 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr6_-_39118211 2.059 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr17_-_6782775 2.058 ENSMUST00000064234.6
 Ezr
ezrin
chr17_-_81649607 1.931 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr1_-_163313661 1.909 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr1_-_97977233 1.793 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr9_-_116175318 1.776 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr8_-_84773381 1.776 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr1_-_14310198 1.731 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr16_+_43235856 1.566 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr6_-_87335758 1.565 ENSMUST00000042025.9
 Antxr1
anthrax toxin receptor 1
chr1_+_16688405 1.539 ENSMUST00000026881.4
 Ly96
lymphocyte antigen 96
chr5_-_104021919 1.525 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr4_-_136886187 1.482 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr2_+_128126030 1.458 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
 Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr5_-_104021799 1.376 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr3_+_138065052 1.212 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0051592 response to calcium ion(GO:0051592)
1.1 3.2 GO:0006553 lysine metabolic process(GO:0006553)
0.3 2.9 GO:0042447 hormone catabolic process(GO:0042447)
0.7 2.1 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.4 1.9 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.9 GO:0048664 neuron fate determination(GO:0048664)
0.4 1.8 GO:0003430 tolerance induction to self antigen(GO:0002513) growth plate cartilage chondrocyte growth(GO:0003430)
0.2 1.8 GO:0009404 toxin metabolic process(GO:0009404)
0.1 1.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 1.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.5 1.6 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.4 1.5 GO:0001907 killing by symbiont of host cells(GO:0001907) induction of programmed cell death(GO:0012502) disruption by symbiont of host cell(GO:0044004) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) positive regulation of fibroblast apoptotic process(GO:2000271)
0.3 1.5 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.1 1.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.0 GO:0010447 response to acidic pH(GO:0010447)
0.3 0.9 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.1 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.9 GO:0005811 lipid particle(GO:0005811)
0.0 2.5 GO:0005901 caveola(GO:0005901)
0.5 2.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 1.9 GO:0014704 intercalated disc(GO:0014704)
0.0 1.8 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.7 GO:0032993 protein-DNA complex(GO:0032993)
0.2 1.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)
0.3 1.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 1.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.7 GO:0005871 kinesin complex(GO:0005871)
0.1 0.6 GO:0097422 tubular endosome(GO:0097422)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.2 0.5 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.0 0.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.4 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.4 2.9 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 2.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 2.1 GO:0044548 S100 protein binding(GO:0044548)
0.1 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.5 1.9 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.6 1.8 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.4 1.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 1.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.6 GO:0005518 collagen binding(GO:0005518)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 1.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 1.5 GO:0045502 dynein binding(GO:0045502)
0.1 1.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.0 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.9 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.8 GO:0016594 glycine binding(GO:0016594)
0.0 0.7 GO:0003777 microtubule motor activity(GO:0003777)