Motif ID: Irf5_Irf6

Z-value: 0.855

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6






Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_141010759 4.329 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr4_-_40239779 4.148 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr17_-_6782775 3.269 ENSMUST00000064234.6
Ezr
ezrin
chr6_-_39118211 3.036 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr16_+_35938972 2.489 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr11_+_88999376 2.296 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr4_-_40239700 2.181 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr19_+_55741810 2.073 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_-_77519565 2.069 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr3_+_138065052 2.047 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr4_-_136886187 1.775 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_+_49246131 1.360 ENSMUST00000064395.6
Nav2
neuron navigator 2
chr1_-_163313661 1.352 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr15_+_9436028 1.000 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr9_+_45042425 0.974 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr16_-_67620880 0.974 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2

cell adhesion molecule 2

chr16_-_67620805 0.931 ENSMUST00000120594.1
Cadm2
cell adhesion molecule 2
chr16_+_35938470 0.928 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr7_+_128523576 0.667 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr11_+_72689997 0.657 ENSMUST00000155998.1
Ankfy1
ankyrin repeat and FYVE domain containing 1
chrX_+_77511002 0.649 ENSMUST00000088217.5
Tbl1x
transducin (beta)-like 1 X-linked
chr9_+_20868628 0.638 ENSMUST00000043911.7
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr12_-_31950210 0.566 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr2_-_77170592 0.563 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr16_-_5255923 0.550 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr12_-_31950170 0.514 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr8_-_105568298 0.481 ENSMUST00000005849.5
Agrp
agouti related protein
chr17_-_78882508 0.409 ENSMUST00000024884.4
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr17_+_34203527 0.363 ENSMUST00000025197.5
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_-_31950535 0.337 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr2_-_51934644 0.335 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr1_+_52119438 0.325 ENSMUST00000070968.7
Stat1
signal transducer and activator of transcription 1
chr9_-_123851855 0.296 ENSMUST00000184082.1
ENSMUST00000167595.2
Fyco1

FYVE and coiled-coil domain containing 1

chr10_+_80249106 0.263 ENSMUST00000105364.1
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr2_-_69586021 0.260 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
Lrp2


low density lipoprotein receptor-related protein 2


chr10_+_80249441 0.257 ENSMUST00000020361.6
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr5_+_99979061 0.256 ENSMUST00000046721.1
4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr9_+_55326913 0.251 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr12_+_26469204 0.213 ENSMUST00000020969.3
Cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chrM_+_9452 0.198 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chrM_+_8600 0.192 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr4_+_108460000 0.152 ENSMUST00000097925.2
Zcchc11
zinc finger, CCHC domain containing 11
chr9_-_14381242 0.152 ENSMUST00000167549.1
Endod1
endonuclease domain containing 1
chr5_-_24447587 0.139 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
Tmub1



transmembrane and ubiquitin-like domain containing 1



chr6_-_87838671 0.135 ENSMUST00000089497.4
Isy1
ISY1 splicing factor homolog (S. cerevisiae)
chr7_-_65370908 0.129 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr12_-_78980758 0.127 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr15_-_76243401 0.091 ENSMUST00000165738.1
ENSMUST00000075689.6
Parp10

poly (ADP-ribose) polymerase family, member 10

chr9_+_57072024 0.090 ENSMUST00000169879.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr17_+_23679363 0.085 ENSMUST00000024699.2
Cldn6
claudin 6
chr17_+_34644805 0.061 ENSMUST00000174796.1
Fkbpl
FK506 binding protein-like
chr7_-_141266415 0.031 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
Irf7


interferon regulatory factor 7


chr3_+_142496924 0.031 ENSMUST00000090127.2
Gbp5
guanylate binding protein 5
chr10_-_43174521 0.017 ENSMUST00000040275.7
Sobp
sine oculis-binding protein homolog (Drosophila)
chr9_-_123862023 0.014 ENSMUST00000182350.1
ENSMUST00000078755.2
Xcr1

chemokine (C motif) receptor 1

chr11_+_69966896 0.012 ENSMUST00000151515.1
Cldn7
claudin 7
chr6_-_13608011 0.008 ENSMUST00000031554.2
Tmem168
transmembrane protein 168

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0009597 detection of virus(GO:0009597)
1.1 3.3 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.5 3.4 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.3 6.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.3 1.4 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.3 2.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 0.7 GO:0032439 endosome localization(GO:0032439)
0.1 1.4 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 1.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.4 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 0.3 GO:0060333 regulation of macrophage fusion(GO:0034239) interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 0.2 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.1 0.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0000389 generation of catalytic spliceosome for second transesterification step(GO:0000350) mRNA 3'-splice site recognition(GO:0000389)
0.0 1.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.0 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.0 0.1 GO:1902915 negative regulation of protein import into nucleus, translocation(GO:0033159) protein poly-ADP-ribosylation(GO:0070212) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.6 GO:0034340 response to type I interferon(GO:0034340)
0.0 0.5 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.3 GO:0045056 transcytosis(GO:0045056)
0.0 0.7 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 1.4 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 2.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.6 GO:0051642 centrosome localization(GO:0051642)
0.0 0.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 2.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.1 6.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.7 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 1.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0005876 spindle microtubule(GO:0005876)
0.0 3.8 GO:0045177 apical part of cell(GO:0045177)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 3.3 GO:0044548 S100 protein binding(GO:0044548)
0.2 2.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.4 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 6.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 2.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.2 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.1 0.3 GO:0030492 hemoglobin binding(GO:0030492)
0.0 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.5 GO:0048038 quinone binding(GO:0048038)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.2 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 2.1 GO:0002039 p53 binding(GO:0002039)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.4 GO:0008201 heparin binding(GO:0008201)
0.0 1.9 GO:0050839 cell adhesion molecule binding(GO:0050839)