Motif ID: Irf5_Irf6

Z-value: 0.855

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6



Activity profile for motif Irf5_Irf6.

activity profile for motif Irf5_Irf6


Sorted Z-values histogram for motif Irf5_Irf6

Sorted Z-values for motif Irf5_Irf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 57 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_141010759 4.329 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr4_-_40239779 4.148 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr17_-_6782775 3.269 ENSMUST00000064234.6
 Ezr
ezrin
chr6_-_39118211 3.036 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr16_+_35938972 2.489 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr11_+_88999376 2.296 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
 Trim25


tripartite motif-containing 25


chr4_-_40239700 2.181 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr19_+_55741810 2.073 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_-_77519565 2.069 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr3_+_138065052 2.047 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr4_-_136886187 1.775 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_+_49246131 1.360 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr1_-_163313661 1.352 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr15_+_9436028 1.000 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr9_+_45042425 0.974 ENSMUST00000034600.4
 Mpzl2
myelin protein zero-like 2
chr16_-_67620880 0.974 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr16_-_67620805 0.931 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr16_+_35938470 0.928 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr7_+_128523576 0.667 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3
chr11_+_72689997 0.657 ENSMUST00000155998.1
 Ankfy1
ankyrin repeat and FYVE domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
1.6 6.3 GO:0009597 detection of virus(GO:0009597)
0.5 3.4 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.1 3.3 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.3 2.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 2.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 1.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 1.4 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 1.4 GO:0048664 neuron fate determination(GO:0048664)
0.0 1.4 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.2 0.7 GO:0032439 endosome localization(GO:0032439)
0.0 0.7 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.6 GO:0034340 response to type I interferon(GO:0034340)
0.0 0.6 GO:0051642 centrosome localization(GO:0051642)
0.1 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.5 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.4 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 0.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.3 GO:0060333 regulation of macrophage fusion(GO:0034239) interferon-gamma-mediated signaling pathway(GO:0060333)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 3.8 GO:0045177 apical part of cell(GO:0045177)
0.8 3.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 2.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.7 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.6 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 6.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 3.3 GO:0044548 S100 protein binding(GO:0044548)
0.2 2.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 2.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 2.1 GO:0002039 p53 binding(GO:0002039)
0.0 1.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.4 GO:0008201 heparin binding(GO:0008201)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.5 GO:0048038 quinone binding(GO:0048038)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.4 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 0.3 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.2 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.0 0.2 GO:0050265 RNA uridylyltransferase activity(GO:0050265)