Motif ID: Irx5

Z-value: 0.671


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.462.7e-02Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 4.893 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_79908428 2.070 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr12_+_38783503 1.886 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_55598917 1.845 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr7_-_114927726 1.603 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr2_-_79908389 1.599 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr6_+_50110837 1.239 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr3_+_124321031 1.231 ENSMUST00000058994.4
 Tram1l1
translocation associated membrane protein 1-like 1
chr9_-_78378725 1.068 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr2_-_85035487 1.021 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr14_-_19977040 0.990 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977151 0.962 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr10_-_88146867 0.869 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr1_-_78968079 0.768 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr2_-_101621033 0.737 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr3_+_95124476 0.721 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr14_-_19977249 0.709 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_+_48120841 0.682 ENSMUST00000073150.4
 Peli2
pellino 2
chr11_-_68927049 0.674 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr5_-_88675190 0.662 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr4_+_148039097 0.659 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr12_-_108893197 0.659 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr1_+_165301863 0.649 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr4_-_49521036 0.634 ENSMUST00000057829.3
 Mrpl50
mitochondrial ribosomal protein L50
chr10_+_3872667 0.633 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr10_-_99759658 0.592 ENSMUST00000056085.4
 Csl
citrate synthase like
chr3_-_126998408 0.544 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr4_+_43632185 0.525 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr4_-_43653542 0.510 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr4_-_43653560 0.485 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chr11_-_28339867 0.464 ENSMUST00000042595.6
 Gm6685
predicted pseudogene 6685
chr4_+_43631935 0.463 ENSMUST00000030191.8
 Npr2
natriuretic peptide receptor 2
chr12_-_67222549 0.456 ENSMUST00000037181.8
 Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr4_+_6365650 0.447 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
 Sdcbp




syndecan binding protein




chr8_+_85171322 0.439 ENSMUST00000076896.5
 Gm6531
predicted gene 6531
chr1_-_169969143 0.431 ENSMUST00000027989.6
ENSMUST00000111353.3
 Hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

chr10_+_88146992 0.404 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr4_-_59783800 0.400 ENSMUST00000107526.1
ENSMUST00000095063.4
 Inip

INTS3 and NABP interacting protein

chr11_-_69579320 0.399 ENSMUST00000048139.5
 Wrap53
WD repeat containing, antisense to Trp53
chr16_+_33185045 0.397 ENSMUST00000039733.8
 Osbpl11
oxysterol binding protein-like 11
chr17_+_21657582 0.369 ENSMUST00000039726.7
 3110052M02Rik
RIKEN cDNA 3110052M02 gene
chr11_-_69395333 0.360 ENSMUST00000108660.1
ENSMUST00000051620.4
 Cyb5d1

cytochrome b5 domain containing 1

chr16_-_56024628 0.343 ENSMUST00000119981.1
ENSMUST00000096021.3
 Pcnp

PEST proteolytic signal containing nuclear protein

chr14_-_14120904 0.329 ENSMUST00000022256.3
 Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr12_-_85288419 0.319 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type
chrX_+_135742686 0.315 ENSMUST00000113144.1
ENSMUST00000113147.1
ENSMUST00000113145.1
ENSMUST00000096321.2
 Gprasp1


Armcx5
G protein-coupled receptor associated sorting protein 1


armadillo repeat containing, X-linked 5
chr12_-_99393010 0.303 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr7_+_45785331 0.299 ENSMUST00000120005.1
ENSMUST00000123585.1
 Lmtk3

lemur tyrosine kinase 3

chr2_-_73625731 0.284 ENSMUST00000070579.6
 Chn1
chimerin (chimaerin) 1
chr13_+_24943144 0.278 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr11_+_69098937 0.248 ENSMUST00000021271.7
 Per1
period circadian clock 1
chr10_-_13868779 0.227 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr16_-_55838827 0.206 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr5_+_48242549 0.198 ENSMUST00000172493.1
 Slit2
slit homolog 2 (Drosophila)
chr7_-_98112618 0.172 ENSMUST00000153657.1
 Myo7a
myosin VIIA
chr3_+_63963631 0.170 ENSMUST00000181653.1
 Gm26850
predicted gene, 26850
chr12_+_69893105 0.133 ENSMUST00000021466.8
 Atl1
atlastin GTPase 1
chr6_-_24956106 0.125 ENSMUST00000127247.2
 Tmem229a
transmembrane protein 229A
chr2_+_104027823 0.124 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
 Fbxo3


F-box protein 3


chr9_+_78051938 0.104 ENSMUST00000024104.7
 Gcm1
glial cells missing homolog 1 (Drosophila)
chr11_-_49712674 0.088 ENSMUST00000020624.6
ENSMUST00000145353.1
 Cnot6

CCR4-NOT transcription complex, subunit 6

chr18_+_76944384 0.074 ENSMUST00000156454.1
ENSMUST00000150990.1
ENSMUST00000026485.7
ENSMUST00000148955.1
 Hdhd2



haloacid dehalogenase-like hydrolase domain containing 2



chr9_-_7835255 0.031 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr10_+_79960145 0.029 ENSMUST00000045247.7
 Wdr18
WD repeat domain 18
chr5_+_23787691 0.010 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
 Rint1



RAD50 interactor 1



chr7_-_142576492 0.005 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA
chr8_+_4240105 0.005 ENSMUST00000110994.1
ENSMUST00000110995.1
 Map2k7

mitogen-activated protein kinase kinase 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 1.0 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.2 0.7 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 3.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.7 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 1.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.9 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.3 GO:0010986 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.4 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.1 0.4 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.1 1.2 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 0.7 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.2 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.6 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 1.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.1 GO:0007566 embryo implantation(GO:0007566)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 1.0 GO:0007338 single fertilization(GO:0007338)
0.0 0.0 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.7 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.4 GO:0070876 SOSS complex(GO:0070876)
0.1 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.5 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.5 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 0.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 0.7 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 1.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 1.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 2.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.4 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.3 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.4 GO:0045545 syndecan binding(GO:0045545)
0.1 1.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)