Motif ID: Irx6_Irx2_Irx3

Z-value: 0.756

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx2mm10_v2_chr13_+_72632597_72632625-0.369.3e-02Click!
Irx6mm10_v2_chr8_+_92674289_92674289-0.096.8e-01Click!
Irx3mm10_v2_chr8_-_91801547_918015600.038.9e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_124493793 2.612 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr1_+_45311538 2.253 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr8_+_84872105 1.805 ENSMUST00000136026.1
ENSMUST00000170296.1
 Syce2

synaptonemal complex central element protein 2

chr18_+_35770318 1.699 ENSMUST00000165299.1
 Gm16490
predicted gene 16490
chr12_-_74316394 1.464 ENSMUST00000110441.1
 Gm11042
predicted gene 11042
chr11_-_26591729 1.232 ENSMUST00000109504.1
 Vrk2
vaccinia related kinase 2
chr10_+_61171954 1.225 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr2_+_124089961 1.133 ENSMUST00000103241.1
 Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr7_-_79386943 1.125 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr17_+_17316078 1.062 ENSMUST00000105311.3
 Gm6712
predicted gene 6712
chr6_-_48708206 1.016 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr7_-_103827922 1.007 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr14_-_30353468 0.989 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr7_-_112159034 0.985 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr13_+_76579670 0.965 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr13_+_49504774 0.958 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_-_98667264 0.835 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr6_+_80019008 0.785 ENSMUST00000126399.1
ENSMUST00000136421.1
 Lrrtm4

leucine rich repeat transmembrane neuronal 4

chr2_-_67433181 0.783 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr6_+_58833689 0.751 ENSMUST00000041401.8
 Herc3
hect domain and RLD 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 1.8 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.3 1.3 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.1 1.3 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 1.1 GO:0007601 visual perception(GO:0007601)
0.3 1.0 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 1.0 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 1.0 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 0.8 GO:0032382 positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) positive regulation of cholesterol import(GO:1904109) positive regulation of sterol import(GO:2000911)
0.0 0.8 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.0 0.7 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 0.7 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 0.6 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.6 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.2 0.5 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 0.5 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.5 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 0.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 0.5 GO:0046085 adenosine metabolic process(GO:0046085)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.6 1.8 GO:0000801 central element(GO:0000801)
0.3 1.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.1 0.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.6 GO:0005787 signal peptidase complex(GO:0005787)
0.2 0.5 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.3 GO:0072534 perineuronal net(GO:0072534)
0.1 0.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 1.3 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.2 1.1 GO:0019841 retinol binding(GO:0019841)
0.0 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.0 GO:0070052 collagen V binding(GO:0070052)
0.3 1.0 GO:0031720 haptoglobin binding(GO:0031720)
0.2 1.0 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 1.0 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.2 0.8 GO:0033814 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.1 0.7 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.6 GO:0042895 antibiotic transporter activity(GO:0042895)
0.1 0.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)