Motif ID: Isl1

Z-value: 0.445


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_116309699-0.443.4e-02Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_89520152 2.375 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr3_-_49757257 2.355 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr1_-_56978534 2.317 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr9_-_40346290 1.681 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr18_-_15718046 1.592 ENSMUST00000053017.6
 Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr8_+_84723003 1.559 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr4_-_126325641 1.242 ENSMUST00000131113.1
 Tekt2
tektin 2
chrX_+_99975570 0.982 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
 Eda








ectodysplasin-A








chr15_-_50889691 0.855 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr14_+_124005355 0.845 ENSMUST00000166105.1
 Gm17615
predicted gene, 17615
chr4_-_82850721 0.753 ENSMUST00000139401.1
 Zdhhc21
zinc finger, DHHC domain containing 21
chr4_+_154964117 0.752 ENSMUST00000030931.4
ENSMUST00000070953.4
 Pank4

pantothenate kinase 4

chr13_+_76579670 0.746 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr14_-_118052235 0.716 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr17_-_51810866 0.674 ENSMUST00000176669.1
 Satb1
special AT-rich sequence binding protein 1
chr7_+_45017953 0.671 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr9_+_37367354 0.626 ENSMUST00000051839.7
 Hepacam
hepatocyte cell adhesion molecule
chr13_+_63282142 0.586 ENSMUST00000159152.1
 2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr18_-_42579652 0.570 ENSMUST00000054738.3
 Gpr151
G protein-coupled receptor 151
chr4_+_108719649 0.533 ENSMUST00000178992.1
 3110021N24Rik
RIKEN cDNA 3110021N24 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 2.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 2.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.2 1.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 1.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 1.0 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.9 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.8 GO:0032196 transposition(GO:0032196)
0.1 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.8 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.8 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.5 GO:0001880 Mullerian duct regression(GO:0001880) osteoblast fate commitment(GO:0002051)
0.1 0.5 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.4 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)
0.1 0.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.3 GO:0097513 myosin II filament(GO:0097513)
0.0 0.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.0 GO:0070939 Dsl1p complex(GO:0070939)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 1.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 1.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 0.8 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 0.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.1 0.5 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.3 GO:0019002 GMP binding(GO:0019002)
0.1 0.3 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.2 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.1 0.2 GO:0015217 ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)