Motif ID: Isl2

Z-value: 0.936


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 185 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 2.567 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr1_+_110099295 2.191 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr9_+_53771499 2.135 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr17_-_48432723 2.085 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr15_+_16778101 2.075 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr16_-_16829276 2.047 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr12_+_109546409 1.939 ENSMUST00000143847.1
 Meg3
maternally expressed 3
chr12_-_10900296 1.772 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chrX_+_136245065 1.767 ENSMUST00000048687.4
 Wbp5
WW domain binding protein 5
chr3_-_33082004 1.581 ENSMUST00000108225.3
 Pex5l
peroxisomal biogenesis factor 5-like
chr17_+_17402672 1.578 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr9_-_100506844 1.457 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr6_-_136941887 1.420 ENSMUST00000111891.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr4_+_136172367 1.411 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr14_-_31323884 1.399 ENSMUST00000048603.7
 Dnah1
dynein, axonemal, heavy chain 1
chr8_-_61902669 1.331 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr15_+_84232030 1.326 ENSMUST00000023072.6
 Parvb
parvin, beta
chr17_+_12119274 1.321 ENSMUST00000024594.2
 Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chrY_-_1245753 1.313 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr1_-_139377094 1.307 ENSMUST00000131586.1
ENSMUST00000145244.1
 Crb1

crumbs homolog 1 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0007530 sex determination(GO:0007530)
0.1 2.1 GO:0080111 DNA demethylation(GO:0080111)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 1.6 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.6 GO:0097352 autophagosome maturation(GO:0097352)
0.4 1.5 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.5 1.4 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.3 1.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 1.4 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.1 1.4 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.4 1.3 GO:0009106 lipoate metabolic process(GO:0009106)
0.2 1.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 1.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.3 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.2 GO:0021591 ventricular system development(GO:0021591)
0.4 1.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.2 1.1 GO:0001842 neural fold formation(GO:0001842)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 1.6 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.3 GO:0002102 podosome(GO:0002102)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.1 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.3 1.0 GO:0036156 inner dynein arm(GO:0036156)
0.3 1.0 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.1 0.8 GO:0001740 Barr body(GO:0001740)
0.0 0.8 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.7 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.7 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 0.7 GO:0061617 MICOS complex(GO:0061617)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0060187 cell pole(GO:0060187)
0.1 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 1.9 GO:0050699 WW domain binding(GO:0050699)
0.3 1.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.5 1.4 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.2 1.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 1.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 1.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.3 GO:0016415 octanoyltransferase activity(GO:0016415)
0.2 1.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.1 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.3 1.0 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 1.0 GO:0042923 neuropeptide binding(GO:0042923)
0.1 0.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)