Motif ID: Klf1

Z-value: 1.826


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_849019920.341.1e-01Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_92599671 4.186 ENSMUST00000065797.6
 Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr7_+_44310213 3.623 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr11_-_95587691 3.364 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr15_+_83791939 3.237 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr7_-_46179929 3.212 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr6_+_5725639 3.119 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr5_-_139325616 2.968 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr10_-_81025521 2.909 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr14_+_70554056 2.877 ENSMUST00000022691.7
 Hr
hairless
chr11_+_98348404 2.344 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr12_-_4841583 2.161 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr10_+_3366125 2.050 ENSMUST00000043374.5
 Ppp1r14c
protein phosphatase 1, regulatory (inhibitor) subunit 14c
chr10_+_127078886 2.034 ENSMUST00000039259.6
 Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr9_+_69454066 2.008 ENSMUST00000134907.1
 Anxa2
annexin A2
chr6_-_126740151 1.981 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr9_+_69453620 1.951 ENSMUST00000034756.8
ENSMUST00000123470.1
 Anxa2

annexin A2

chr18_-_38211957 1.914 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr7_-_19861299 1.899 ENSMUST00000014830.7
 Ceacam16
carcinoembryonic antigen-related cell adhesion molecule 16
chrX_+_153237466 1.868 ENSMUST00000143880.1
 Klf8
Kruppel-like factor 8
chr9_-_107710475 1.832 ENSMUST00000080560.3
 Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 583 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.8 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.4 5.7 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.3 4.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 4.2 GO:0006012 galactose metabolic process(GO:0006012)
0.7 4.0 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.3 3.9 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
1.2 3.6 GO:0046959 habituation(GO:0046959)
1.1 3.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.3 3.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 3.4 GO:0009268 response to pH(GO:0009268)
0.1 3.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.5 3.2 GO:0032796 uropod organization(GO:0032796)
0.1 3.2 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.6 3.0 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1 3.0 GO:0007608 sensory perception of smell(GO:0007608)
0.3 2.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 2.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.9 GO:0051260 protein homooligomerization(GO:0051260)
0.5 2.8 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.2 2.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 242 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.3 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 7.4 GO:0005912 adherens junction(GO:0005912)
0.5 7.0 GO:0043196 varicosity(GO:0043196)
0.1 6.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 5.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 5.3 GO:0032590 dendrite membrane(GO:0032590)
0.2 5.2 GO:0071565 nBAF complex(GO:0071565)
0.5 5.1 GO:0045298 tubulin complex(GO:0045298)
0.0 5.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 4.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 4.8 GO:0008021 synaptic vesicle(GO:0008021)
0.3 4.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.3 3.9 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 3.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 3.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.9 GO:0097440 apical dendrite(GO:0097440)
0.1 2.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 2.7 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 2.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.6 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 374 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.6 6.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 5.9 GO:0003924 GTPase activity(GO:0003924)
0.0 5.5 GO:0003779 actin binding(GO:0003779)
0.2 5.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 5.3 GO:0030507 spectrin binding(GO:0030507)
0.2 4.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 4.6 GO:0030276 clathrin binding(GO:0030276)
1.1 4.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 4.3 GO:0019905 syntaxin binding(GO:0019905)
1.0 4.0 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.8 3.9 GO:0045503 dynein light chain binding(GO:0045503)
0.4 3.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.4 3.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 3.2 GO:0015485 cholesterol binding(GO:0015485)
0.6 3.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 3.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 2.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 2.9 GO:0042809 vitamin D receptor binding(GO:0042809)