Motif ID: Klf12_Klf14_Sp4

Z-value: 1.549

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp4mm10_v2_chr12_-_118301429_1183014580.501.6e-02Click!
Klf12mm10_v2_chr14_-_100149764_1001497640.242.7e-01Click!


Activity profile for motif Klf12_Klf14_Sp4.

activity profile for motif Klf12_Klf14_Sp4


Sorted Z-values histogram for motif Klf12_Klf14_Sp4

Sorted Z-values for motif Klf12_Klf14_Sp4



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_58076456 6.871 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr5_+_134986191 5.806 ENSMUST00000094245.2
 Cldn3
claudin 3
chr2_+_172345565 5.641 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr9_+_80165079 5.624 ENSMUST00000184480.1
 Myo6
myosin VI
chr5_-_99252839 5.427 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr9_+_80165013 5.202 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr7_+_107595051 4.732 ENSMUST00000040056.7
 Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_+_46761578 4.271 ENSMUST00000077666.4
ENSMUST00000099373.4
 Cnnm2

cyclin M2

chr4_-_22488296 4.261 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr4_+_139574697 4.255 ENSMUST00000174078.1
 Iffo2
intermediate filament family orphan 2
chr14_+_60634719 4.228 ENSMUST00000022566.7
ENSMUST00000159729.1
 Spata13

spermatogenesis associated 13

chr13_-_49215978 4.197 ENSMUST00000048946.6
 1110007C09Rik
RIKEN cDNA 1110007C09 gene
chr15_+_25622525 4.036 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr7_-_19118357 3.818 ENSMUST00000141380.1
 Gm4969
predicted gene 4969
chr11_-_109611417 3.590 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
 Wipi1


WD repeat domain, phosphoinositide interacting 1


chr14_-_18239053 3.544 ENSMUST00000090543.5
 Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr3_-_85887472 3.414 ENSMUST00000033643.5
ENSMUST00000154148.1
 Glt28d2
Arfip1
glycosyltransferase 28 domain containing 2
ADP-ribosylation factor interacting protein 1
chr18_+_64340225 3.413 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr5_-_109558957 3.390 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr1_-_195092242 3.353 ENSMUST00000162650.1
ENSMUST00000160817.1
ENSMUST00000162614.1
ENSMUST00000016637.6
 Cd46



CD46 antigen, complement regulatory protein




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 657 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.0 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.4 5.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 5.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.5 5.0 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.6 4.8 GO:0006601 creatine biosynthetic process(GO:0006601)
0.3 4.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.3 4.7 GO:0015693 magnesium ion transport(GO:0015693)
0.5 4.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 3.8 GO:0008360 regulation of cell shape(GO:0008360)
0.4 3.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 3.7 GO:0007601 visual perception(GO:0007601)
0.5 3.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.4 3.6 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.9 3.5 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.9 3.5 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 3.5 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 3.5 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
1.1 3.4 GO:0043379 memory T cell differentiation(GO:0043379)
0.7 3.4 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.6 3.4 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 11.6 GO:0005615 extracellular space(GO:0005615)
0.1 10.3 GO:0030175 filopodium(GO:0030175)
0.0 9.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 7.7 GO:0001726 ruffle(GO:0001726)
0.3 7.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 6.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 6.8 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)
0.3 6.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 6.0 GO:0045335 phagocytic vesicle(GO:0045335)
0.3 5.0 GO:0002080 acrosomal membrane(GO:0002080)
0.3 4.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 4.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 4.0 GO:0045177 apical part of cell(GO:0045177)
0.6 3.8 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.2 3.7 GO:0005605 basal lamina(GO:0005605)
0.6 3.6 GO:0016011 dystroglycan complex(GO:0016011)
0.4 3.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 3.3 GO:0005882 intermediate filament(GO:0005882)
0.1 3.3 GO:0031519 PcG protein complex(GO:0031519)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 417 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.1 GO:0051015 actin filament binding(GO:0051015)
0.0 12.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 12.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 9.9 GO:0005125 cytokine activity(GO:0005125)
0.0 6.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 6.6 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.1 4.9 GO:0071837 HMG box domain binding(GO:0071837)
0.2 4.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 4.4 GO:0017166 vinculin binding(GO:0017166)
0.1 4.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 4.0 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.2 4.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.7 3.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 3.9 GO:0017046 peptide hormone binding(GO:0017046)
0.2 3.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.6 3.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.5 3.5 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.3 3.5 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 3.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 3.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)