Motif ID: Klf16_Sp8

Z-value: 0.957

Transcription factors associated with Klf16_Sp8:

Gene SymbolEntrez IDGene Name
Klf16 ENSMUSG00000035397.8 Klf16
Sp8 ENSMUSG00000048562.6 Sp8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp8mm10_v2_chr12_+_118846329_1188463290.387.5e-02Click!
Klf16mm10_v2_chr10_-_80577285_80577327-0.039.0e-01Click!


Activity profile for motif Klf16_Sp8.

activity profile for motif Klf16_Sp8


Sorted Z-values histogram for motif Klf16_Sp8

Sorted Z-values for motif Klf16_Sp8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf16_Sp8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_100759740 6.302 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_-_100759942 5.031 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr12_+_17690793 4.703 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr4_-_117133953 4.634 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr5_+_139543889 4.081 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_-_127534540 3.850 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chrX_-_141725181 3.814 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr8_+_87473116 3.814 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr2_-_34372004 3.704 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr4_-_41695442 3.695 ENSMUST00000102961.3
ENSMUST00000064443.6
 Cntfr

ciliary neurotrophic factor receptor

chr4_+_128883549 3.658 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr8_-_105471481 3.655 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr8_+_105518736 3.544 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr18_+_49979514 3.518 ENSMUST00000179937.1
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr11_+_44617310 3.495 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr2_+_164960809 3.450 ENSMUST00000124372.1
 Slc12a5
solute carrier family 12, member 5
chr7_-_31051431 3.399 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr18_+_49979427 3.357 ENSMUST00000148989.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr8_+_87472805 3.314 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr9_-_39604124 3.232 ENSMUST00000042485.4
ENSMUST00000141370.1
 AW551984

expressed sequence AW551984


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 933 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.7 8.2 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
1.2 8.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.2 6.7 GO:0051310 metaphase plate congression(GO:0051310)
0.1 6.7 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.6 6.4 GO:0003360 brainstem development(GO:0003360)
0.3 5.8 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.4 5.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.2 5.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
1.3 5.3 GO:0035262 gonad morphogenesis(GO:0035262)
1.0 4.8 GO:0007386 compartment pattern specification(GO:0007386)
0.4 4.8 GO:0044458 motile cilium assembly(GO:0044458)
0.2 4.7 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.5 4.6 GO:0090166 Golgi disassembly(GO:0090166)
0.2 4.4 GO:0034508 centromere complex assembly(GO:0034508)
0.7 4.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.4 4.0 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.2 4.0 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 4.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 3.9 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 362 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 GO:0005876 spindle microtubule(GO:0005876)
0.1 7.2 GO:0000776 kinetochore(GO:0000776)
2.1 6.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 5.5 GO:0005795 Golgi stack(GO:0005795)
0.8 4.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.3 4.3 GO:0043196 varicosity(GO:0043196)
0.6 4.1 GO:0000796 condensin complex(GO:0000796)
0.2 4.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 4.0 GO:0005814 centriole(GO:0005814)
1.3 3.8 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 3.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 3.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 3.5 GO:0001741 XY body(GO:0001741)
0.2 3.5 GO:0071565 nBAF complex(GO:0071565)
0.1 3.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.4 GO:0030286 dynein complex(GO:0030286)
0.3 3.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 3.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 533 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 10.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 9.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.6 8.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 8.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.7 7.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 7.0 GO:0042393 histone binding(GO:0042393)
0.2 6.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 6.7 GO:0005112 Notch binding(GO:0005112)
0.4 6.5 GO:0031005 filamin binding(GO:0031005)
0.9 5.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 4.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.5 4.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 4.6 GO:0003924 GTPase activity(GO:0003924)
0.9 4.3 GO:0032027 myosin light chain binding(GO:0032027)
0.2 4.3 GO:0015026 coreceptor activity(GO:0015026)
0.1 4.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 3.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 3.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.6 3.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)