Motif ID: Klf4_Sp3

Z-value: 1.587

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf4mm10_v2_chr4_-_55532453_555324850.135.6e-01Click!
Sp3mm10_v2_chr2_-_72980402_72980471-0.106.6e-01Click!


Activity profile for motif Klf4_Sp3.

activity profile for motif Klf4_Sp3


Sorted Z-values histogram for motif Klf4_Sp3

Sorted Z-values for motif Klf4_Sp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_87473116 16.364 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr7_+_29289300 11.140 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr10_-_127534540 11.031 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr4_-_117133953 9.213 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr8_+_87472805 9.158 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr8_+_87472838 8.953 ENSMUST00000180806.2
 Gm2694
predicted gene 2694
chr6_-_115994953 8.877 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr8_-_87472576 8.608 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr7_-_34812677 8.530 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr7_-_31051431 8.375 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr8_-_87472365 8.268 ENSMUST00000169693.1
 Cbln1
cerebellin 1 precursor protein
chr6_-_72958097 7.850 ENSMUST00000114049.1
 Tmsb10
thymosin, beta 10
chr3_-_8667033 7.661 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr1_-_175692624 7.492 ENSMUST00000027809.7
 Opn3
opsin 3
chr11_-_95587691 7.095 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr2_+_164960809 6.851 ENSMUST00000124372.1
 Slc12a5
solute carrier family 12, member 5
chr8_+_105518736 6.834 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr5_-_113908685 6.696 ENSMUST00000004646.6
 Coro1c
coronin, actin binding protein 1C
chr7_-_143460989 6.608 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr7_+_45163915 6.477 ENSMUST00000085374.5
 Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,060 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 18.2 GO:0035690 cellular response to drug(GO:0035690)
1.2 13.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
1.0 13.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 12.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
1.5 10.5 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.4 10.2 GO:0051310 metaphase plate congression(GO:0051310)
1.2 9.9 GO:0008343 adult feeding behavior(GO:0008343)
0.9 9.9 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
3.2 9.5 GO:0018298 protein-chromophore linkage(GO:0018298)
1.0 9.2 GO:0090166 Golgi disassembly(GO:0090166)
0.5 9.0 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.4 9.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.4 8.9 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 8.8 GO:0021516 dorsal spinal cord development(GO:0021516)
0.7 8.7 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.2 8.5 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.7 8.4 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.6 8.4 GO:0050832 defense response to fungus(GO:0050832)
2.0 8.1 GO:0035262 gonad morphogenesis(GO:0035262)
1.6 8.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 392 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.7 17.3 GO:0071565 nBAF complex(GO:0071565)
1.0 14.9 GO:0043196 varicosity(GO:0043196)
0.2 14.6 GO:0030496 midbody(GO:0030496)
0.1 14.6 GO:0043204 perikaryon(GO:0043204)
0.5 13.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 12.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 11.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 11.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.0 11.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.3 10.7 GO:0005876 spindle microtubule(GO:0005876)
1.2 10.4 GO:0005883 neurofilament(GO:0005883)
0.4 9.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 9.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 8.9 GO:0070469 respiratory chain(GO:0070469)
0.1 8.9 GO:0031225 anchored component of membrane(GO:0031225)
0.3 8.5 GO:0002102 podosome(GO:0002102)
0.1 8.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 8.2 GO:0000922 spindle pole(GO:0000922)
0.6 8.1 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 575 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 23.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.5 20.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.6 18.7 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.5 15.2 GO:0003785 actin monomer binding(GO:0003785)
1.6 14.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 14.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 13.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 13.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.9 12.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 11.9 GO:0008017 microtubule binding(GO:0008017)
0.8 11.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.8 11.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.7 11.3 GO:0031005 filamin binding(GO:0031005)
0.2 11.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 11.0 GO:0002039 p53 binding(GO:0002039)
0.2 10.1 GO:0048487 beta-tubulin binding(GO:0048487)
3.2 9.5 GO:0009881 photoreceptor activity(GO:0009881)
0.2 9.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.0 9.3 GO:0001972 retinoic acid binding(GO:0001972)