Motif ID: Klf7

Z-value: 0.554


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64122256_64122321-0.511.3e-02Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 2.595 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr12_-_11436607 0.957 ENSMUST00000072299.5
 Vsnl1
visinin-like 1
chr1_-_138847579 0.857 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr5_+_140607334 0.803 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr12_-_4592927 0.802 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr5_+_137761680 0.708 ENSMUST00000110983.2
ENSMUST00000031738.4
 Tsc22d4

TSC22 domain family, member 4

chr9_-_32344237 0.660 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr4_-_87230435 0.611 ENSMUST00000107157.2
 Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr5_+_33658123 0.588 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr18_+_67133713 0.570 ENSMUST00000076605.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr10_+_79682169 0.556 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr15_+_99074968 0.527 ENSMUST00000039665.6
 Troap
trophinin associated protein
chrX_+_136270253 0.490 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr2_+_158375638 0.482 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr13_+_21722057 0.454 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr4_+_152178126 0.401 ENSMUST00000075363.3
 Acot7
acyl-CoA thioesterase 7
chr2_+_119047116 0.392 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr11_-_70654624 0.387 ENSMUST00000018437.2
 Pfn1
profilin 1
chr7_+_58658181 0.379 ENSMUST00000168747.1
 Atp10a
ATPase, class V, type 10A
chr2_+_172550991 0.373 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr5_-_136135989 0.365 ENSMUST00000150406.1
ENSMUST00000006301.4
 Lrwd1

leucine-rich repeats and WD repeat domain containing 1

chr2_-_151973387 0.346 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr4_+_63558748 0.343 ENSMUST00000077709.4
 6330416G13Rik
RIKEN cDNA 6330416G13 gene
chr5_+_136136202 0.338 ENSMUST00000143229.1
 Alkbh4
alkB, alkylation repair homolog 4 (E. coli)
chr2_+_119047129 0.337 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr15_-_98953541 0.335 ENSMUST00000097014.5
 Tuba1a
tubulin, alpha 1A
chr5_+_136136137 0.330 ENSMUST00000136634.1
ENSMUST00000041100.3
 Alkbh4

alkB, alkylation repair homolog 4 (E. coli)

chr5_+_137778849 0.329 ENSMUST00000126126.1
ENSMUST00000031739.4
 Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr3_+_51224447 0.325 ENSMUST00000023849.8
ENSMUST00000167780.1
 Ccrn4l

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

chr8_+_105860634 0.323 ENSMUST00000008594.7
 Nutf2
nuclear transport factor 2
chr1_-_23383149 0.308 ENSMUST00000027343.5
 Ogfrl1
opioid growth factor receptor-like 1
chr9_-_71485893 0.308 ENSMUST00000034720.5
 Polr2m
polymerase (RNA) II (DNA directed) polypeptide M
chr16_-_91931643 0.261 ENSMUST00000023677.3
 Atp5o
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr7_+_45154644 0.259 ENSMUST00000153973.1
 Pih1d1
PIH1 domain containing 1
chr7_-_28766469 0.243 ENSMUST00000085851.5
ENSMUST00000032815.4
 Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr8_+_70152754 0.238 ENSMUST00000072500.6
ENSMUST00000164040.1
ENSMUST00000110146.2
ENSMUST00000110143.1
ENSMUST00000110141.2
ENSMUST00000110140.1
 2310045N01Rik

Mef2b



RIKEN cDNA 2310045N01 gene

myocyte enhancer factor 2B



chr7_+_45154297 0.228 ENSMUST00000107813.1
ENSMUST00000125953.1
ENSMUST00000085375.5
ENSMUST00000144597.1
 Pih1d1



PIH1 domain containing 1



chr5_+_45520221 0.205 ENSMUST00000156481.1
ENSMUST00000119579.1
ENSMUST00000118833.1
 Med28


mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)


chr1_+_171329015 0.202 ENSMUST00000111300.1
 Dedd
death effector domain-containing
chr2_-_156312470 0.188 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr10_+_86705811 0.188 ENSMUST00000061458.7
ENSMUST00000075632.6
 BC030307

cDNA sequence BC030307

chr11_+_40733639 0.187 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr7_+_28350652 0.184 ENSMUST00000082134.4
 Rps16
ribosomal protein S16
chr11_+_72301613 0.180 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr4_-_132329414 0.177 ENSMUST00000127402.1
ENSMUST00000105962.3
ENSMUST00000030730.7
ENSMUST00000105960.1
 Trnau1ap



tRNA selenocysteine 1 associated protein 1



chr8_-_84966008 0.173 ENSMUST00000109738.3
ENSMUST00000065049.8
ENSMUST00000128972.1
 Rnaseh2a


ribonuclease H2, large subunit


chr8_+_3621529 0.172 ENSMUST00000156380.2
 Pet100
PET100 homolog (S. cerevisiae)
chr11_-_120991039 0.167 ENSMUST00000070575.7
 Csnk1d
casein kinase 1, delta
chr17_+_26113286 0.162 ENSMUST00000025010.7
 Tmem8
transmembrane protein 8 (five membrane-spanning domains)
chr15_+_30172570 0.161 ENSMUST00000081728.5
 Ctnnd2
catenin (cadherin associated protein), delta 2
chr2_+_34772089 0.156 ENSMUST00000028222.6
ENSMUST00000100171.2
 Hspa5

heat shock protein 5

chr5_-_115348953 0.155 ENSMUST00000040154.8
 Cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr7_-_114117761 0.153 ENSMUST00000069449.5
 Rras2
related RAS viral (r-ras) oncogene homolog 2
chr11_+_78536355 0.136 ENSMUST00000128788.1
 Ift20
intraflagellar transport 20
chr2_+_32775769 0.135 ENSMUST00000066352.5
 Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr1_+_57406328 0.128 ENSMUST00000027114.5
 9430016H08Rik
RIKEN cDNA 9430016H08 gene
chr11_-_120991305 0.124 ENSMUST00000018274.3
 Csnk1d
casein kinase 1, delta
chr12_+_118846329 0.123 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr7_-_127993831 0.120 ENSMUST00000033056.3
 Pycard
PYD and CARD domain containing
chr7_-_45154519 0.120 ENSMUST00000007977.7
ENSMUST00000107815.1
 Aldh16a1

aldehyde dehydrogenase 16 family, member A1

chr11_-_40733373 0.113 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr2_+_156312589 0.103 ENSMUST00000073942.5
ENSMUST00000109580.1
 Cnbd2

cyclic nucleotide binding domain containing 2

chr11_+_80383279 0.101 ENSMUST00000165565.1
ENSMUST00000017567.7
 Zfp207

zinc finger protein 207

chr8_+_84901928 0.086 ENSMUST00000067060.7
 Klf1
Kruppel-like factor 1 (erythroid)
chr11_-_78536235 0.084 ENSMUST00000017759.2
ENSMUST00000108277.2
 Tnfaip1

tumor necrosis factor, alpha-induced protein 1 (endothelial)

chr7_-_19404082 0.082 ENSMUST00000108458.3
 Klc3
kinesin light chain 3
chr1_+_58445531 0.081 ENSMUST00000151272.1
 Nif3l1
Ngg1 interacting factor 3-like 1 (S. pombe)
chr5_-_124187150 0.081 ENSMUST00000161938.1
 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr13_-_14613017 0.079 ENSMUST00000015816.3
 Mrpl32
mitochondrial ribosomal protein L32
chr7_-_101011976 0.078 ENSMUST00000178340.1
ENSMUST00000037540.3
 P2ry2

purinergic receptor P2Y, G-protein coupled 2

chr7_+_80261202 0.076 ENSMUST00000117989.1
 Ngrn
neugrin, neurite outgrowth associated
chr8_+_3500451 0.075 ENSMUST00000004683.6
ENSMUST00000160338.1
 Mcoln1

mucolipin 1

chr7_-_141414115 0.071 ENSMUST00000106008.1
 Pddc1
Parkinson disease 7 domain containing 1
chr11_-_110251736 0.066 ENSMUST00000044003.7
 Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr7_+_126976338 0.064 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr7_-_116198487 0.060 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr2_-_73892619 0.056 ENSMUST00000112007.1
ENSMUST00000112016.2
 Atf2

activating transcription factor 2

chr16_-_56717286 0.053 ENSMUST00000121554.1
ENSMUST00000128551.1
 Tfg

Trk-fused gene

chr11_-_89639631 0.043 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr11_-_106779483 0.037 ENSMUST00000021060.5
 Polg2
polymerase (DNA directed), gamma 2, accessory subunit
chr11_-_101302206 0.029 ENSMUST00000140706.1
ENSMUST00000170502.1
ENSMUST00000172233.1
ENSMUST00000130916.1
 Becn1



beclin 1, autophagy related



chr5_-_137741601 0.028 ENSMUST00000119498.1
ENSMUST00000061789.7
 Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr7_+_28766747 0.026 ENSMUST00000170068.1
ENSMUST00000072965.4
 Sirt2

sirtuin 2

chr19_-_8723356 0.022 ENSMUST00000170157.1
 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_-_120121030 0.019 ENSMUST00000027634.6
 Dbi
diazepam binding inhibitor
chr2_-_73892588 0.016 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
 Atf2


activating transcription factor 2


chr11_+_78536393 0.014 ENSMUST00000050366.8
ENSMUST00000108275.1
 Ift20

intraflagellar transport 20

chr1_+_58445151 0.011 ENSMUST00000087521.6
ENSMUST00000114337.1
 Nif3l1

Ngg1 interacting factor 3-like 1 (S. pombe)

chr1_-_120120937 0.007 ENSMUST00000151708.1
 Dbi
diazepam binding inhibitor
chr9_-_45936049 0.007 ENSMUST00000034590.2
 Tagln
transgelin
chr8_-_126945841 0.006 ENSMUST00000179857.1
 Tomm20
translocase of outer mitochondrial membrane 20 homolog (yeast)
chr11_+_42419729 0.006 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr4_+_152297205 0.003 ENSMUST00000048892.7
 Icmt
isoprenylcysteine carboxyl methyltransferase
chr1_+_167689108 0.000 ENSMUST00000111377.1
 Lmx1a
LIM homeobox transcription factor 1 alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.2 0.9 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 0.8 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.4 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 0.5 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110)
0.1 0.4 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.4 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.1 0.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.3 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.1 0.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.6 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.2 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 0.7 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.7 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.8 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.0 0.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 1.0 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.7 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.1 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.2 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.0 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.0 0.3 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.0 0.0 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.6 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.3 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.7 GO:0006970 response to osmotic stress(GO:0006970)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097255 R2TP complex(GO:0097255)
0.1 0.4 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.7 GO:0070938 contractile ring(GO:0070938)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.1 GO:1990047 spindle matrix(GO:1990047)
0.0 0.1 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.3 0.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.6 GO:0050827 toxin receptor binding(GO:0050827)
0.1 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.6 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.5 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.0 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.1 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.1 GO:0019145 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0019172 glyoxalase III activity(GO:0019172)
0.0 0.7 GO:0018602 sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)