Motif ID: Klf8

Z-value: 0.585


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237466_1532374660.262.3e-01Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 1.510 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr1_-_33907721 1.200 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr19_+_8664005 1.023 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr11_-_116654245 1.015 ENSMUST00000021166.5
 Cygb
cytoglobin
chr19_+_5740885 1.010 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr7_-_142657466 0.961 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr6_-_136173492 0.959 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr5_-_123132651 0.877 ENSMUST00000031401.5
 Rhof
ras homolog gene family, member f
chr18_-_74961252 0.826 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr2_-_118703963 0.797 ENSMUST00000104937.1
 Ankrd63
ankyrin repeat domain 63
chr12_+_84009481 0.774 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr12_-_25096080 0.724 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr2_-_36105271 0.719 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr2_-_168741898 0.707 ENSMUST00000109176.1
ENSMUST00000178504.1
 Atp9a

ATPase, class II, type 9A

chr1_-_184883218 0.678 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr14_-_30353468 0.652 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr7_-_57509995 0.637 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr10_+_99263224 0.590 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr9_-_51077064 0.580 ENSMUST00000098782.3
 Layn
layilin
chr10_-_127666598 0.576 ENSMUST00000099157.3
 Nab2
Ngfi-A binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.0 1.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.3 1.0 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 1.0 GO:0015671 oxygen transport(GO:0015671)
0.2 1.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 1.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 1.0 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 1.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 0.9 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.3 0.8 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.3 0.8 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.0 0.8 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.2 0.7 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.7 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.7 GO:0019346 homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.1 0.7 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 0.6 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.6 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.1 0.6 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 0.6 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 1.0 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 1.0 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.7 GO:0031526 brush border membrane(GO:0031526)
0.2 0.6 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.2 0.5 GO:0045160 myosin I complex(GO:0045160)
0.1 0.5 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.1 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:1902737 dendritic filopodium(GO:1902737)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.5 GO:0045503 dynein light chain binding(GO:0045503)
0.1 1.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 1.0 GO:0004096 catalase activity(GO:0004096)
0.2 1.0 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 1.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 1.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.8 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.8 GO:0005254 chloride channel activity(GO:0005254)
0.1 0.7 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 0.7 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.6 GO:0034711 inhibin binding(GO:0034711)
0.0 0.6 GO:0070513 death domain binding(GO:0070513)
0.0 0.6 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)