Motif ID: Lef1

Z-value: 1.791


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131112785_131112803-0.125.8e-01Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_70474923 8.198 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr14_+_101840602 6.226 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr2_+_116067213 5.861 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr12_-_119238794 5.762 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr19_+_55742242 5.050 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr17_+_35076902 4.973 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr14_+_101729907 4.943 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr10_-_18743691 4.935 ENSMUST00000019999.5
 D10Bwg1379e
DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed
chr1_-_186705980 4.917 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr14_+_101840501 4.740 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr2_-_116067391 4.638 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr3_-_116968827 4.495 ENSMUST00000119557.1
 Palmd
palmdelphin
chr1_+_59482133 4.188 ENSMUST00000114246.2
ENSMUST00000037105.6
 Fzd7

frizzled homolog 7 (Drosophila)

chr3_-_116968969 4.161 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr5_+_17574726 4.156 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr6_+_17463749 4.133 ENSMUST00000115443.1
 Met
met proto-oncogene
chr1_-_165934900 3.980 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
 Pou2f1


POU domain, class 2, transcription factor 1


chr14_-_79771305 3.937 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr2_+_96318014 3.811 ENSMUST00000135431.1
ENSMUST00000162807.2
 Lrrc4c

leucine rich repeat containing 4C

chr6_+_17463927 3.619 ENSMUST00000115442.1
 Met
met proto-oncogene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.6 GO:0016337 single organismal cell-cell adhesion(GO:0016337)
1.6 12.9 GO:0048625 myoblast fate commitment(GO:0048625)
1.2 11.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.4 8.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.3 8.4 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 7.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
1.6 6.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 6.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 5.6 GO:0008360 regulation of cell shape(GO:0008360)
1.8 5.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.6 4.9 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
1.0 4.8 GO:0046684 response to pyrethroid(GO:0046684)
0.0 4.8 GO:0050885 neuromuscular process controlling balance(GO:0050885)
1.5 4.4 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
1.1 4.4 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
1.0 4.2 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.6 4.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.5 3.8 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 3.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2 3.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.3 GO:0005913 cell-cell adherens junction(GO:0005913)
1.4 12.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 12.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 9.7 GO:0005730 nucleolus(GO:0005730)
0.4 6.2 GO:0043205 fibril(GO:0043205)
0.3 5.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
1.4 5.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.3 5.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 5.3 GO:0005614 interstitial matrix(GO:0005614)
0.2 5.0 GO:0033268 node of Ranvier(GO:0033268)
0.3 4.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 4.8 GO:0043235 receptor complex(GO:0043235)
0.0 4.7 GO:0000922 spindle pole(GO:0000922)
0.1 4.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 4.2 GO:0043197 dendritic spine(GO:0043197)
0.0 4.1 GO:0005604 basement membrane(GO:0005604)
0.0 4.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 16.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.5 15.9 GO:0042805 actinin binding(GO:0042805)
2.6 10.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
2.8 8.4 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.6 7.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.2 6.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
1.1 5.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.2 5.0 GO:0031402 sodium ion binding(GO:0031402)
1.2 4.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 4.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 4.4 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.4 4.2 GO:0038191 neuropilin binding(GO:0038191)
0.2 4.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 3.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 3.7 GO:0008201 heparin binding(GO:0008201)
0.0 3.6 GO:0004386 helicase activity(GO:0004386)
0.1 3.3 GO:0070412 R-SMAD binding(GO:0070412)
0.1 3.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 3.2 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.4 3.0 GO:0043237 laminin-1 binding(GO:0043237)