Motif ID: Lhx3

Z-value: 0.610


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_45103747 3.041 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr7_-_103827922 2.858 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr4_+_136143497 2.731 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr13_+_49608030 2.230 ENSMUST00000021822.5
Ogn
osteoglycin
chr4_+_118961578 2.177 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr18_+_57468478 2.074 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr3_+_151437887 1.994 ENSMUST00000046977.7
Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr14_+_80000292 1.763 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr11_+_109543694 1.472 ENSMUST00000106696.1
Arsg
arylsulfatase G
chr8_-_21906412 1.381 ENSMUST00000051965.4
Defb11
defensin beta 11
chr1_+_177444653 1.257 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr2_-_160619971 1.220 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chrX_+_66653003 1.173 ENSMUST00000036043.4
Slitrk2
SLIT and NTRK-like family, member 2
chr5_-_70842617 0.988 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_-_33086366 0.976 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr10_-_62507737 0.952 ENSMUST00000020271.6
Srgn
serglycin
chr4_-_14621805 0.944 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr13_-_101692624 0.940 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr2_-_33087169 0.924 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr5_-_62766153 0.895 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_+_34780412 0.741 ENSMUST00000115016.1
ENSMUST00000115017.1
Agbl3

ATP/GTP binding protein-like 3

chrM_-_14060 0.728 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr17_-_36032682 0.713 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr10_+_36506814 0.686 ENSMUST00000167191.1
ENSMUST00000058738.4
Hs3st5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

chr3_+_66985680 0.675 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr10_-_53647080 0.630 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chrX_+_166344692 0.568 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chr3_+_84952146 0.567 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr3_-_57294880 0.566 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr1_-_158356258 0.556 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr2_-_84425258 0.544 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr2_+_36230426 0.531 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr18_+_37477768 0.529 ENSMUST00000051442.5
Pcdhb16
protocadherin beta 16
chr4_+_102589687 0.516 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr3_-_116712644 0.516 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr3_+_122419772 0.491 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr15_+_98571004 0.417 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr2_+_125136692 0.399 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr3_+_66985647 0.387 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr6_+_124304646 0.382 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chrM_+_9452 0.378 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr3_+_95318782 0.376 ENSMUST00000139866.1
Cers2
ceramide synthase 2
chrX_-_139871637 0.371 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chr17_-_67950908 0.364 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr18_+_60774510 0.319 ENSMUST00000025511.3
Rps14
ribosomal protein S14
chr18_+_60774675 0.304 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chr5_+_66968961 0.302 ENSMUST00000132991.1
Limch1
LIM and calponin homology domains 1
chr10_+_5593718 0.298 ENSMUST00000051809.8
Myct1
myc target 1
chr14_-_48665098 0.290 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr11_-_84069179 0.258 ENSMUST00000138208.1
Dusp14
dual specificity phosphatase 14
chr10_+_75037066 0.205 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr3_+_53845086 0.176 ENSMUST00000108014.1
Gm10985
predicted gene 10985
chr4_+_134930898 0.174 ENSMUST00000030622.2
Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr11_+_59306920 0.172 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr12_-_56536895 0.160 ENSMUST00000001536.8
Nkx2-1
NK2 homeobox 1
chr2_-_164171113 0.147 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr19_+_46397009 0.146 ENSMUST00000118440.1
Sufu
suppressor of fused homolog (Drosophila)
chr10_+_75037291 0.146 ENSMUST00000139384.1
Rab36
RAB36, member RAS oncogene family
chr3_+_41742615 0.125 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr4_-_147809788 0.116 ENSMUST00000105734.3
ENSMUST00000176201.1
Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr4_+_147132038 0.107 ENSMUST00000084149.3
Gm13139
predicted gene 13139
chr3_-_41742471 0.102 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr4_-_14621494 0.099 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chrM_+_14138 0.088 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr7_-_37772868 0.080 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr9_+_96258697 0.078 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr14_-_108914237 0.076 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1
chr1_-_24612700 0.071 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr10_+_23797052 0.070 ENSMUST00000133289.1
Slc18b1
solute carrier family 18, subfamily B, member 1
chrM_+_9870 0.070 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr10_+_102158858 0.064 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr11_-_4095344 0.062 ENSMUST00000004868.5
Mtfp1
mitochondrial fission process 1
chr3_+_136670076 0.057 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr1_-_36273425 0.054 ENSMUST00000056946.6
Neurl3
neuralized homolog 3 homolog (Drosophila)
chr4_+_147492417 0.036 ENSMUST00000105721.2
Gm13152
predicted gene 13152
chr5_+_122422440 0.030 ENSMUST00000031422.3
ENSMUST00000119792.1
Anapc7

anaphase promoting complex subunit 7

chr9_+_120929216 0.017 ENSMUST00000130466.1
Ctnnb1
catenin (cadherin associated protein), beta 1
chr10_+_116143881 0.010 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr3_+_142620596 0.009 ENSMUST00000165774.1
Gbp2
guanylate binding protein 2
chrX_-_8252304 0.009 ENSMUST00000115594.1
Ftsj1
FtsJ homolog 1 (E. coli)
chr14_+_69347587 0.009 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr4_+_146610961 0.008 ENSMUST00000130825.1
Gm13248
predicted gene 13248
chr2_+_110597298 0.006 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr17_-_56036546 0.004 ENSMUST00000003268.9
Sh3gl1
SH3-domain GRB2-like 1
chr7_-_45830776 0.001 ENSMUST00000107723.2
ENSMUST00000131384.1
Grwd1

glutamate-rich WD repeat containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.2 0.7 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 0.5 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.6 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 0.5 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.7 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.5 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 2.7 GO:0071398 cellular response to fatty acid(GO:0071398)
0.1 0.9 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.4 GO:0014012 negative regulation of Schwann cell proliferation(GO:0010626) peripheral nervous system axon regeneration(GO:0014012)
0.1 0.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.6 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 2.2 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 1.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 3.0 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0033762 response to glucagon(GO:0033762)
0.0 0.4 GO:0006953 acute-phase response(GO:0006953)
0.0 0.1 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.4 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.4 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 1.8 GO:0042581 specific granule(GO:0042581)
0.1 1.0 GO:0042629 mast cell granule(GO:0042629)
0.1 1.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.3 GO:0070469 respiratory chain(GO:0070469)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0019770 IgG receptor activity(GO:0019770)
0.7 2.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.7 2.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 0.9 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 1.5 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 0.5 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.6 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.0 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.1 2.2 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.8 GO:0045296 cadherin binding(GO:0045296)
0.0 1.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 2.2 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)