Motif ID: Lhx4
Z-value: 0.609
Transcription factors associated with Lhx4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Lhx4 | ENSMUSG00000026468.8 | Lhx4 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.0 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.4 | 1.7 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.3 | 1.0 | GO:0009193 | pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048) |
0.2 | 0.5 | GO:1902336 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
0.2 | 0.7 | GO:0021893 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) |
0.2 | 1.2 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
0.2 | 0.7 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.2 | 1.1 | GO:0060591 | chondroblast differentiation(GO:0060591) |
0.2 | 0.6 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.2 | 0.9 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
0.2 | 2.9 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.2 | 0.5 | GO:0030210 | heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014) |
0.2 | 0.3 | GO:1990791 | dorsal root ganglion development(GO:1990791) |
0.2 | 0.3 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
0.1 | 0.4 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
0.1 | 0.5 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
0.1 | 0.8 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
0.1 | 0.3 | GO:0035106 | operant conditioning(GO:0035106) |
0.1 | 1.1 | GO:0042428 | serotonin metabolic process(GO:0042428) |
0.1 | 0.7 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
0.1 | 0.5 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
0.1 | 3.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.1 | 0.4 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
0.1 | 0.4 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.1 | 1.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
0.1 | 0.2 | GO:0008594 | photoreceptor cell morphogenesis(GO:0008594) |
0.1 | 0.5 | GO:2000809 | positive regulation of synaptic vesicle clustering(GO:2000809) |
0.1 | 0.2 | GO:0060023 | soft palate development(GO:0060023) |
0.1 | 0.3 | GO:0070295 | renal water absorption(GO:0070295) |
0.1 | 0.2 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
0.1 | 0.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.1 | 0.5 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
0.0 | 0.4 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
0.0 | 0.2 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
0.0 | 0.2 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
0.0 | 0.7 | GO:0021860 | pyramidal neuron development(GO:0021860) |
0.0 | 0.2 | GO:0051661 | maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684) |
0.0 | 0.6 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
0.0 | 0.3 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
0.0 | 0.2 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.0 | 0.3 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
0.0 | 0.1 | GO:0090298 | negative regulation of mitochondrial DNA replication(GO:0090298) |
0.0 | 0.1 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
0.0 | 0.3 | GO:0070475 | rRNA base methylation(GO:0070475) |
0.0 | 0.1 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.0 | 0.1 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.0 | 1.1 | GO:0006376 | mRNA splice site selection(GO:0006376) |
0.0 | 1.0 | GO:0035082 | axoneme assembly(GO:0035082) |
0.0 | 1.5 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
0.0 | 1.6 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
0.0 | 0.3 | GO:0060736 | prostate gland growth(GO:0060736) |
0.0 | 0.1 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
0.0 | 0.2 | GO:0009404 | toxin metabolic process(GO:0009404) |
0.0 | 0.1 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) positive regulation of synaptic vesicle exocytosis(GO:2000302) |
0.0 | 0.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.0 | 0.9 | GO:0031114 | negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114) |
0.0 | 0.4 | GO:0007097 | nuclear migration(GO:0007097) |
0.0 | 0.4 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
0.0 | 0.1 | GO:0021960 | anterior commissure morphogenesis(GO:0021960) retinal bipolar neuron differentiation(GO:0060040) |
0.0 | 0.2 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.0 | 0.2 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
0.0 | 0.1 | GO:0014043 | negative regulation of neuron maturation(GO:0014043) |
0.0 | 0.4 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
0.0 | 0.2 | GO:0030497 | fatty acid elongation(GO:0030497) |
0.0 | 0.6 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
0.0 | 0.1 | GO:0035553 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) |
0.0 | 0.4 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
0.0 | 0.2 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
0.0 | 0.6 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
0.0 | 0.1 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
0.0 | 0.0 | GO:2000425 | regulation of apoptotic cell clearance(GO:2000425) |
0.0 | 0.3 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.0 | GO:0002177 | manchette(GO:0002177) |
0.2 | 3.0 | GO:0043205 | fibril(GO:0043205) |
0.1 | 1.5 | GO:0042581 | specific granule(GO:0042581) |
0.1 | 1.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.1 | 0.5 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.1 | 1.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.1 | 0.4 | GO:0031523 | Myb complex(GO:0031523) |
0.1 | 0.2 | GO:1990393 | 3M complex(GO:1990393) |
0.1 | 0.4 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
0.1 | 0.3 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
0.0 | 0.5 | GO:0030312 | external encapsulating structure(GO:0030312) |
0.0 | 0.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.3 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
0.0 | 0.4 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.0 | 0.6 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
0.0 | 0.1 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.0 | 0.2 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
0.0 | 0.1 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.0 | 0.3 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
0.0 | 0.3 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 1.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.0 | 0.4 | GO:0097440 | apical dendrite(GO:0097440) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.0 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.5 | 1.6 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
0.3 | 0.8 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.2 | 2.9 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.2 | 0.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.2 | 0.5 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
0.2 | 1.1 | GO:0036122 | BMP binding(GO:0036122) |
0.2 | 0.5 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
0.1 | 1.0 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
0.1 | 0.4 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
0.1 | 0.9 | GO:0038191 | neuropilin binding(GO:0038191) |
0.1 | 0.4 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
0.1 | 0.5 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.1 | 0.6 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.1 | 0.2 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
0.1 | 0.5 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.1 | 3.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 1.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.1 | 0.2 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
0.1 | 1.1 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
0.0 | 0.3 | GO:1990188 | euchromatin binding(GO:1990188) |
0.0 | 0.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.0 | 0.3 | GO:0015288 | porin activity(GO:0015288) |
0.0 | 0.4 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
0.0 | 0.5 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
0.0 | 0.1 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) |
0.0 | 1.5 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 0.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
0.0 | 0.7 | GO:0030275 | LRR domain binding(GO:0030275) |
0.0 | 1.5 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 0.6 | GO:0050811 | GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811) |
0.0 | 0.2 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.0 | 0.2 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
0.0 | 0.1 | GO:0051378 | primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378) |
0.0 | 0.7 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.0 | 0.2 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
0.0 | 0.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 1.0 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 3.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.6 | GO:0005402 | cation:sugar symporter activity(GO:0005402) |
0.0 | 0.2 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.0 | 0.3 | GO:0070513 | death domain binding(GO:0070513) |
0.0 | 0.5 | GO:0044653 | trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859) |
0.0 | 0.1 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
0.0 | 0.1 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
0.0 | 0.1 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.0 | 0.1 | GO:0050693 | mediator complex binding(GO:0036033) LBD domain binding(GO:0050693) |
0.0 | 0.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.1 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |