Motif ID: Lhx4

Z-value: 0.609


Transcription factors associated with Lhx4:

Gene SymbolEntrez IDGene Name
Lhx4 ENSMUSG00000026468.8 Lhx4



Activity profile for motif Lhx4.

activity profile for motif Lhx4


Sorted Z-values histogram for motif Lhx4

Sorted Z-values for motif Lhx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 195 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 1.864 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_78684262 1.802 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr16_+_43247278 1.660 ENSMUST00000114691.1
ENSMUST00000079441.6
 Zbtb20

zinc finger and BTB domain containing 20

chr4_+_118961578 1.644 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr16_+_43235856 1.610 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr15_-_8710409 1.538 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_97747399 1.508 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr15_-_8710734 1.497 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_80000292 1.484 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr3_-_49757257 1.420 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr1_+_19103022 1.416 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr5_-_62765618 1.405 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_-_97747373 1.386 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_+_68869563 1.326 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr5_+_118169712 1.202 ENSMUST00000054836.6
 Hrk
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr3_-_85741389 1.185 ENSMUST00000094148.4
 Fam160a1
family with sequence similarity 160, member A1
chr7_-_37773555 1.144 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr2_-_155945282 1.141 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5
chr5_-_28210022 1.053 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr14_+_69347587 1.031 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.8 3.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 2.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 1.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 1.6 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 1.5 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 1.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.2 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.2 1.1 GO:0060591 chondroblast differentiation(GO:0060591)
0.1 1.1 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 1.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 1.0 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.0 1.0 GO:0035082 axoneme assembly(GO:0035082)
0.2 0.9 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.0 0.9 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.1 0.8 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 0.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.2 0.7 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 0.7 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.7 GO:0021860 pyramidal neuron development(GO:0021860)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:0043205 fibril(GO:0043205)
0.1 1.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.5 GO:0042581 specific granule(GO:0042581)
0.2 1.0 GO:0002177 manchette(GO:0002177)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.5 GO:0030312 external encapsulating structure(GO:0030312)
0.1 0.4 GO:0031523 Myb complex(GO:0031523)
0.1 0.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.4 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.4 GO:0097440 apical dendrite(GO:0097440)
0.1 0.3 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.3 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.3 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.6 3.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 2.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.5 1.6 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 1.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.5 GO:0045296 cadherin binding(GO:0045296)
0.2 1.1 GO:0036122 BMP binding(GO:0036122)
0.1 1.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.0 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.3 0.8 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.7 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.6 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.6 GO:0005402 cation:sugar symporter activity(GO:0005402)