Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.481

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx5mm10_v2_chr5_+_120431770_120431905-0.611.9e-03Click!
Lhx1mm10_v2_chr11_-_84525514_84525542-0.472.5e-02Click!
Lmx1bmm10_v2_chr2_-_33640480_33640511-0.145.2e-01Click!


Activity profile for motif Lhx5_Lmx1b_Lhx1.

activity profile for motif Lhx5_Lmx1b_Lhx1


Sorted Z-values histogram for motif Lhx5_Lmx1b_Lhx1

Sorted Z-values for motif Lhx5_Lmx1b_Lhx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_66365905 2.380 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chr5_+_13398688 2.358 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr18_+_57468478 1.842 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr7_-_46667375 1.835 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr14_+_80000292 1.782 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_-_160619971 1.685 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr13_-_105271039 1.390 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr7_-_45103747 1.389 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr8_-_67910911 1.234 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr5_-_28210022 1.046 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr2_+_3770673 1.004 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr8_+_34054622 0.925 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr1_+_58210397 0.908 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chrX_+_16619698 0.885 ENSMUST00000026013.5
 Maoa
monoamine oxidase A
chr11_+_109543694 0.877 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr16_+_11406618 0.745 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr11_-_87359011 0.726 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr19_-_5802640 0.687 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr1_+_19103022 0.670 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr4_+_101986626 0.658 ENSMUST00000106914.1
 Gm12789
predicted gene 12789

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.4 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.3 2.2 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0 1.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.4 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 1.4 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 1.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 0.9 GO:0046110 xanthine metabolic process(GO:0046110)
0.3 0.9 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.7 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.7 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.7 GO:0030901 midbrain development(GO:0030901)
0.2 0.6 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.6 GO:1900170 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 0.6 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.6 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 0.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 0.5 GO:0003406 retinal pigment epithelium development(GO:0003406)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0042581 specific granule(GO:0042581)
0.0 1.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.4 GO:0002177 manchette(GO:0002177)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.4 GO:0038191 neuropilin binding(GO:0038191)
0.7 2.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 1.8 GO:0045296 cadherin binding(GO:0045296)
0.5 1.4 GO:0019770 IgG receptor activity(GO:0019770)
0.0 1.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.0 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.2 0.9 GO:0030151 molybdenum ion binding(GO:0030151)
0.2 0.9 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.1 0.9 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 0.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.6 GO:0034951 pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.0 0.5 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.0 0.5 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 0.5 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.0 0.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.4 GO:0004962 endothelin receptor activity(GO:0004962)