Motif ID: Lhx8

Z-value: 0.705


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.233.0e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_66227573 2.952 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr1_+_6487231 2.587 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr11_+_44617310 1.546 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr8_-_57653023 1.490 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr8_-_57652993 1.221 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr13_-_66852017 1.216 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr13_-_66851513 1.081 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr12_+_38783455 1.040 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr2_-_72986716 0.975 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr1_-_127677923 0.949 ENSMUST00000160616.1
 Tmem163
transmembrane protein 163
chr12_+_38783503 0.935 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr8_+_45627709 0.926 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr13_+_5861489 0.830 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr2_-_67433181 0.780 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr17_-_35027909 0.750 ENSMUST00000040151.2
 Sapcd1
suppressor APC domain containing 1
chr1_-_172027251 0.714 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr11_-_102579071 0.704 ENSMUST00000107080.1
 Gm11627
predicted gene 11627
chr3_+_76075583 0.682 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr10_-_67912620 0.676 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr4_-_155645408 0.647 ENSMUST00000115821.2
 Gm10563
predicted gene 10563

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.4 1.3 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 1.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 1.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.8 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.2 0.7 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.5 GO:0090234 cellular response to testosterone stimulus(GO:0071394) regulation of kinetochore assembly(GO:0090234)
0.1 0.4 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0 0.4 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.3 GO:0060187 cell pole(GO:0060187)
0.1 0.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.4 GO:0072487 MSL complex(GO:0072487)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.3 GO:0031673 H zone(GO:0031673)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 1.0 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.5 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0035497 cAMP response element binding(GO:0035497)