Motif ID: Lhx8

Z-value: 0.705


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.233.0e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_66227573 2.952 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chr1_+_6487231 2.587 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr11_+_44617310 1.546 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1


early B cell factor 1


chr8_-_57653023 1.490 ENSMUST00000034021.5
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr8_-_57652993 1.221 ENSMUST00000110316.2
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr13_-_66852017 1.216 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr13_-_66851513 1.081 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr12_+_38783455 1.040 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr2_-_72986716 0.975 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr1_-_127677923 0.949 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr12_+_38783503 0.935 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr8_+_45627709 0.926 ENSMUST00000134321.1
ENSMUST00000135336.1
Sorbs2

sorbin and SH3 domain containing 2

chr13_+_5861489 0.830 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr2_-_67433181 0.780 ENSMUST00000180773.1
Gm26727
predicted gene, 26727
chr17_-_35027909 0.750 ENSMUST00000040151.2
Sapcd1
suppressor APC domain containing 1
chr1_-_172027251 0.714 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr11_-_102579071 0.704 ENSMUST00000107080.1
Gm11627
predicted gene 11627
chr3_+_76075583 0.682 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr10_-_67912620 0.676 ENSMUST00000064656.7
Zfp365
zinc finger protein 365
chr4_-_155645408 0.647 ENSMUST00000115821.2
Gm10563
predicted gene 10563
chr4_+_126556994 0.642 ENSMUST00000147675.1
Clspn
claspin
chr8_-_69373383 0.584 ENSMUST00000072427.4
Gm10033
predicted gene 10033
chr1_-_172027269 0.580 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr18_-_43687695 0.568 ENSMUST00000082254.6
Jakmip2
janus kinase and microtubule interacting protein 2
chr11_-_102579461 0.533 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr5_+_34336289 0.516 ENSMUST00000182709.1
ENSMUST00000030992.6
Rnf4

ring finger protein 4

chr2_+_65620829 0.491 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr10_-_4432285 0.490 ENSMUST00000155172.1
Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr2_-_114013619 0.483 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr1_+_72284367 0.457 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr9_-_78378725 0.443 ENSMUST00000034900.7
Ooep
oocyte expressed protein
chr16_-_16829276 0.437 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chr11_+_98798653 0.404 ENSMUST00000037930.6
Msl1
male-specific lethal 1 homolog (Drosophila)
chr6_+_11926758 0.402 ENSMUST00000133776.1
Phf14
PHD finger protein 14
chrX_-_163761323 0.402 ENSMUST00000059320.2
Rnf138rt1
ring finger protein 138, retrogene 1
chr14_+_60768120 0.393 ENSMUST00000025940.6
C1qtnf9
C1q and tumor necrosis factor related protein 9
chr15_-_98221056 0.384 ENSMUST00000170618.1
ENSMUST00000141911.1
Olfr287

olfactory receptor 287

chr2_-_52558539 0.379 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr7_-_28372597 0.369 ENSMUST00000144700.1
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr1_+_161969179 0.365 ENSMUST00000111594.2
ENSMUST00000028021.6
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr10_+_58497918 0.354 ENSMUST00000036576.8
Ccdc138
coiled-coil domain containing 138
chr11_-_109995775 0.351 ENSMUST00000020948.8
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr4_+_126556935 0.347 ENSMUST00000048391.8
Clspn
claspin
chr4_-_62502233 0.343 ENSMUST00000037820.2
Hdhd3
haloacid dehalogenase-like hydrolase domain containing 3
chr10_-_4432312 0.342 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
Rmnd1


required for meiotic nuclear division 1 homolog (S. cerevisiae)


chr7_-_28372233 0.337 ENSMUST00000094644.4
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr13_-_62466709 0.334 ENSMUST00000076195.5
Zfp935
zinc finger protein 935
chr3_-_73056943 0.317 ENSMUST00000059407.7
Slitrk3
SLIT and NTRK-like family, member 3
chr1_+_33908172 0.305 ENSMUST00000182513.1
ENSMUST00000183034.1
Dst

dystonin

chr4_+_53011916 0.300 ENSMUST00000107665.3
Nipsnap3b
nipsnap homolog 3B (C. elegans)
chr7_-_28372494 0.294 ENSMUST00000119990.1
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr18_+_23415400 0.273 ENSMUST00000115832.2
ENSMUST00000047954.7
Dtna

dystrobrevin alpha

chr19_-_24961545 0.271 ENSMUST00000025815.8
Cbwd1
COBW domain containing 1
chr9_-_124493793 0.265 ENSMUST00000178787.1
Gm21836
predicted gene, 21836
chr2_-_114175321 0.239 ENSMUST00000043160.6
Aqr
aquarius
chr1_+_86064619 0.234 ENSMUST00000027432.8
Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr14_+_48446128 0.219 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr4_-_41314877 0.208 ENSMUST00000030145.8
Dcaf12
DDB1 and CUL4 associated factor 12
chr3_-_116712696 0.207 ENSMUST00000169530.1
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr2_+_73312601 0.202 ENSMUST00000090811.4
ENSMUST00000112050.1
Scrn3

secernin 3

chr18_+_27598582 0.196 ENSMUST00000050143.3
Gm7729
predicted gene 7729
chr6_-_71440623 0.194 ENSMUST00000002292.8
Rmnd5a
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr15_+_21111452 0.182 ENSMUST00000075132.6
Cdh12
cadherin 12
chrX_+_150589907 0.172 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr9_+_44334685 0.170 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr5_+_121795034 0.169 ENSMUST00000162327.1
Atxn2
ataxin 2
chr3_-_100685431 0.155 ENSMUST00000008907.7
Man1a2
mannosidase, alpha, class 1A, member 2
chr12_-_20900867 0.150 ENSMUST00000079237.5
Zfp125
zinc finger protein 125
chr13_-_49652714 0.147 ENSMUST00000021818.7
Cenpp
centromere protein P
chr11_+_45852031 0.143 ENSMUST00000109261.3
ENSMUST00000109260.1
Clint1

clathrin interactor 1

chr18_-_31911903 0.140 ENSMUST00000054984.6
Sft2d3
SFT2 domain containing 3
chr1_-_74588117 0.135 ENSMUST00000066986.6
Zfp142
zinc finger protein 142
chr8_+_34054622 0.135 ENSMUST00000149618.1
Gm9951
predicted gene 9951
chr8_+_110079758 0.131 ENSMUST00000058804.8
Zfp612
zinc finger protein 612
chr14_-_48662740 0.129 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr3_+_89773562 0.128 ENSMUST00000038356.8
Ube2q1
ubiquitin-conjugating enzyme E2Q (putative) 1
chr17_+_17374332 0.125 ENSMUST00000024620.6
Riok2
RIO kinase 2 (yeast)
chr7_+_12977834 0.122 ENSMUST00000108537.1
ENSMUST00000108535.1
ENSMUST00000045810.7
Zfp446


zinc finger protein 446


chr17_+_8182247 0.117 ENSMUST00000161898.1
Fgfr1op
Fgfr1 oncogene partner
chr14_+_54625305 0.101 ENSMUST00000097177.4
Psmb11
proteasome (prosome, macropain) subunit, beta type, 11
chr3_-_59210881 0.099 ENSMUST00000040622.1
P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr7_-_60005101 0.098 ENSMUST00000059305.10
Snrpn
small nuclear ribonucleoprotein N
chr15_-_83595111 0.094 ENSMUST00000016901.3
Ttll12
tubulin tyrosine ligase-like family, member 12
chr14_+_48446340 0.093 ENSMUST00000111735.2
Tmem260
transmembrane protein 260
chr1_-_44218952 0.090 ENSMUST00000054801.3
Mettl21e
methyltransferase like 21E
chr10_-_19907545 0.086 ENSMUST00000134220.1
Pex7
peroxisomal biogenesis factor 7
chr5_+_137553517 0.080 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
Actl6b




actin-like 6B




chr12_+_80790532 0.074 ENSMUST00000068519.5
4933426M11Rik
RIKEN cDNA 4933426M11 gene
chr7_-_60005049 0.062 ENSMUST00000179360.1
Snurf
SNRPN upstream reading frame
chr1_-_170867761 0.061 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr5_-_98566762 0.049 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr11_-_102407455 0.044 ENSMUST00000107098.1
ENSMUST00000018821.2
Slc25a39

solute carrier family 25, member 39

chr5_+_67306941 0.043 ENSMUST00000162372.1
ENSMUST00000113676.2
Slc30a9

solute carrier family 30 (zinc transporter), member 9

chr8_+_104831572 0.040 ENSMUST00000059449.6
Ces2b
carboxyesterase 2B
chr2_+_21205719 0.035 ENSMUST00000054591.3
ENSMUST00000102952.1
ENSMUST00000138965.1
ENSMUST00000138914.1
ENSMUST00000102951.1
Thnsl1




threonine synthase-like 1 (bacterial)




chr1_+_164048214 0.034 ENSMUST00000027874.5
Sele
selectin, endothelial cell
chr14_+_46832127 0.033 ENSMUST00000068532.8
Cgrrf1
cell growth regulator with ring finger domain 1
chr11_+_26387194 0.020 ENSMUST00000109509.1
ENSMUST00000136830.1
Fancl

Fanconi anemia, complementation group L

chr1_+_72307413 0.015 ENSMUST00000027379.8
Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr7_+_91090697 0.011 ENSMUST00000107196.2
Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 0.010 ENSMUST00000074273.3
Dlg2
discs, large homolog 2 (Drosophila)
chr2_-_175131864 0.009 ENSMUST00000108929.2
Gm14399
predicted gene 14399
chr11_+_16257706 0.008 ENSMUST00000109645.2
ENSMUST00000109647.2
Vstm2a

V-set and transmembrane domain containing 2A

chr9_+_56994932 0.005 ENSMUST00000034832.6
Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chr3_-_144760841 0.005 ENSMUST00000059091.5
Clca1
chloride channel calcium activated 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.7 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.4 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 1.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.5 GO:0090234 cellular response to testosterone stimulus(GO:0071394) regulation of kinetochore assembly(GO:0090234)
0.1 0.8 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 2.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.4 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0060187 cell pole(GO:0060187)
0.1 0.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.4 GO:0072487 MSL complex(GO:0072487)
0.1 0.3 GO:0031673 H zone(GO:0031673)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 2.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.5 GO:0033142 progesterone receptor binding(GO:0033142)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0035497 cAMP response element binding(GO:0035497)