Motif ID: Mafa

Z-value: 0.536


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_757479220.378.1e-02Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_102254739 1.507 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr11_-_66525964 1.349 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr9_-_98032983 1.318 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr16_-_17576631 1.164 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
 Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr10_-_84440591 0.967 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr1_-_136260873 0.876 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr12_-_75177325 0.814 ENSMUST00000042299.2
 Kcnh5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr4_+_102254993 0.813 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chrX_-_73869804 0.812 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr11_-_66525795 0.812 ENSMUST00000123454.1
 Shisa6
shisa homolog 6 (Xenopus laevis)
chrX_+_104482774 0.795 ENSMUST00000087867.5
 Uprt
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr4_+_21931291 0.793 ENSMUST00000029908.7
 Faxc
failed axon connections homolog (Drosophila)
chr1_-_169747634 0.750 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr14_+_119138415 0.671 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr9_-_98033181 0.665 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr10_+_58813359 0.661 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr8_-_70487314 0.652 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr19_+_27217011 0.598 ENSMUST00000164746.1
ENSMUST00000172302.1
 Vldlr

very low density lipoprotein receptor

chr5_+_111417263 0.591 ENSMUST00000094463.4
 Mn1
meningioma 1
chr16_-_74411776 0.580 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr5_+_124629050 0.483 ENSMUST00000037865.8
 Atp6v0a2
ATPase, H+ transporting, lysosomal V0 subunit A2
chr11_+_87595646 0.465 ENSMUST00000134216.1
 Mtmr4
myotubularin related protein 4
chr4_+_42035113 0.447 ENSMUST00000098127.1
 Gm10597
predicted gene 10597
chr4_+_155601854 0.436 ENSMUST00000118607.1
 Slc35e2
solute carrier family 35, member E2
chr19_+_27217357 0.422 ENSMUST00000047645.6
ENSMUST00000167487.1
 Vldlr

very low density lipoprotein receptor

chr2_-_125506385 0.417 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr5_-_124187150 0.406 ENSMUST00000161938.1
 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr11_-_119228461 0.387 ENSMUST00000036113.3
 Tbc1d16
TBC1 domain family, member 16
chr8_+_105373265 0.374 ENSMUST00000160650.1
 Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr17_-_46752170 0.368 ENSMUST00000121671.1
ENSMUST00000059844.6
 Cnpy3

canopy 3 homolog (zebrafish)

chr17_-_47010513 0.359 ENSMUST00000113337.2
ENSMUST00000113335.2
 Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr7_-_12684991 0.342 ENSMUST00000172743.1
ENSMUST00000167771.1
 Vmn2r55

vomeronasal 2, receptor 55

chrX_-_20950597 0.290 ENSMUST00000009550.7
 Elk1
ELK1, member of ETS oncogene family
chrX_-_95444789 0.277 ENSMUST00000084535.5
 Amer1
APC membrane recruitment 1
chr9_-_51077064 0.274 ENSMUST00000098782.3
 Layn
layilin
chr7_+_54835959 0.271 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr12_+_3365108 0.264 ENSMUST00000020999.5
 Kif3c
kinesin family member 3C
chr9_-_48835932 0.264 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chr4_+_43406435 0.227 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr4_-_59138983 0.203 ENSMUST00000107547.1
 AI481877
expressed sequence AI481877
chr1_-_38836090 0.193 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr2_-_166155272 0.191 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr17_-_47611449 0.191 ENSMUST00000024783.8
 Bysl
bystin-like
chr12_-_86884808 0.190 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like
chr16_-_74411292 0.180 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr9_-_105131775 0.176 ENSMUST00000035179.6
 Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chrX_+_152178945 0.173 ENSMUST00000096275.4
 Iqsec2
IQ motif and Sec7 domain 2
chr11_+_98927785 0.160 ENSMUST00000107474.1
 Rara
retinoic acid receptor, alpha
chr16_+_20651652 0.158 ENSMUST00000007212.8
 Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr5_+_24423805 0.136 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr9_+_108002501 0.131 ENSMUST00000035214.4
ENSMUST00000175874.1
 Ip6k1

inositol hexaphosphate kinase 1

chr1_-_121327776 0.130 ENSMUST00000160688.1
 Insig2
insulin induced gene 2
chr11_-_107337556 0.125 ENSMUST00000040380.6
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr9_-_45906837 0.124 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
 Rnf214


ring finger protein 214


chr17_+_47611570 0.118 ENSMUST00000024778.2
 Med20
mediator complex subunit 20
chr12_+_105453831 0.109 ENSMUST00000178224.1
 D430019H16Rik
RIKEN cDNA D430019H16 gene
chr4_+_124802543 0.067 ENSMUST00000138807.1
ENSMUST00000030723.2
ENSMUST00000175875.1
 Mtf1


metal response element binding transcription factor 1


chr11_+_119229092 0.067 ENSMUST00000053440.7
 Ccdc40
coiled-coil domain containing 40
chr13_+_93771656 0.066 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chrX_+_151047170 0.061 ENSMUST00000026296.7
 Fgd1
FYVE, RhoGEF and PH domain containing 1
chrX_-_93832106 0.057 ENSMUST00000045748.6
 Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr11_-_59787636 0.046 ENSMUST00000125307.1
 Pld6
phospholipase D family, member 6
chr2_-_92401237 0.038 ENSMUST00000050312.2
 Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr8_+_93810832 0.038 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr7_+_140856957 0.032 ENSMUST00000026558.6
 Ric8
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
chr13_+_24943144 0.024 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr9_-_65580040 0.022 ENSMUST00000068944.7
 Plekho2
pleckstrin homology domain containing, family O member 2
chr1_-_121327672 0.017 ENSMUST00000159085.1
ENSMUST00000159125.1
ENSMUST00000161818.1
 Insig2


insulin induced gene 2


chr13_+_4233730 0.016 ENSMUST00000081326.6
 Akr1c19
aldo-keto reductase family 1, member C19
chr2_+_36230426 0.014 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr10_-_75932468 0.009 ENSMUST00000120281.1
ENSMUST00000000924.6
 Mmp11

matrix metallopeptidase 11

chr1_-_121327734 0.005 ENSMUST00000160968.1
ENSMUST00000162582.1
 Insig2

insulin induced gene 2

chr8_-_105565985 0.005 ENSMUST00000013304.7
 Atp6v0d1
ATPase, H+ transporting, lysosomal V0 subunit D1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.3 0.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.0 GO:0034436 glycoprotein transport(GO:0034436)
0.2 2.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.4 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.1 0.8 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 2.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.4 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1 0.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.0 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 0.6 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.8 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.5 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.3 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.0 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.3 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.2 GO:0046709 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.0 1.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.0 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.0 0.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.0 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.0 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 2.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.4 GO:0001527 microfibril(GO:0001527)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.2 0.8 GO:0033691 sialic acid binding(GO:0033691)
0.2 0.8 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.8 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)
0.1 2.3 GO:0030552 cAMP binding(GO:0030552)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.0 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.2 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)