Motif ID: Mecom

Z-value: 0.627


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 10.471 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr7_-_103853199 1.246 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr11_-_81968415 0.827 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr1_+_45311538 0.799 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr6_+_96113146 0.461 ENSMUST00000122120.1
 Fam19a1
family with sequence similarity 19, member A1
chr2_+_103970221 0.453 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chr10_-_6980376 0.415 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr1_+_120006980 0.409 ENSMUST00000072886.4
 Sctr
secretin receptor
chr3_+_36552600 0.348 ENSMUST00000029269.5
ENSMUST00000136890.1
 Exosc9

exosome component 9

chr2_-_149798701 0.340 ENSMUST00000148202.1
ENSMUST00000139471.1
 Gm14133

predicted gene 14133

chr2_+_103970115 0.334 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chr2_+_103969528 0.319 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr1_+_107511489 0.308 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 0.298 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr15_-_48791933 0.295 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
 Csmd3


CUB and Sushi multiple domains 3


chr10_+_5593718 0.290 ENSMUST00000051809.8
 Myct1
myc target 1
chr3_+_106034661 0.259 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chr14_+_34375504 0.253 ENSMUST00000111908.1
 Mmrn2
multimerin 2
chr9_+_64235201 0.211 ENSMUST00000039011.3
 Uchl4
ubiquitin carboxyl-terminal esterase L4
chr12_-_86079019 0.191 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr8_-_18741542 0.187 ENSMUST00000033846.6
 Angpt2
angiopoietin 2
chr4_+_41569775 0.184 ENSMUST00000102963.3
 Dnaic1
dynein, axonemal, intermediate chain 1
chr11_-_60046477 0.181 ENSMUST00000000310.7
ENSMUST00000102693.2
ENSMUST00000148512.1
 Pemt


phosphatidylethanolamine N-methyltransferase


chr9_+_105053239 0.178 ENSMUST00000035177.8
ENSMUST00000149243.1
 Mrpl3

mitochondrial ribosomal protein L3

chr10_+_61648552 0.155 ENSMUST00000020286.6
 Ppa1
pyrophosphatase (inorganic) 1
chr18_+_4994600 0.153 ENSMUST00000140448.1
 Svil
supervillin
chr5_-_136198908 0.151 ENSMUST00000149151.1
ENSMUST00000151786.1
 Prkrip1

Prkr interacting protein 1 (IL11 inducible)

chr19_-_37176055 0.132 ENSMUST00000142973.1
ENSMUST00000154376.1
 Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr14_-_124677089 0.127 ENSMUST00000095529.3
 Fgf14
fibroblast growth factor 14
chrX_-_88760312 0.123 ENSMUST00000182943.1
 Gm27000
predicted gene, 27000
chr18_-_43477764 0.121 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr1_+_152399824 0.120 ENSMUST00000044311.8
 Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr1_+_156838915 0.119 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr7_+_82337218 0.119 ENSMUST00000173828.1
 Adamtsl3
ADAMTS-like 3
chr13_+_49544443 0.114 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr2_+_18672384 0.104 ENSMUST00000171845.1
ENSMUST00000061158.4
 Commd3

COMM domain containing 3

chr9_+_115909455 0.093 ENSMUST00000119291.1
ENSMUST00000069651.6
 Gadl1

glutamate decarboxylase-like 1

chr10_-_80701811 0.086 ENSMUST00000003438.9
 Mob3a
MOB kinase activator 3A
chr13_+_89540636 0.083 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr9_+_65890237 0.072 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chrX_+_169879596 0.071 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr16_-_29541483 0.064 ENSMUST00000057018.8
ENSMUST00000182627.1
 Atp13a4

ATPase type 13A4

chr5_+_134582690 0.056 ENSMUST00000023867.6
 Rfc2
replication factor C (activator 1) 2
chr5_+_129715488 0.050 ENSMUST00000119576.1
ENSMUST00000042191.5
ENSMUST00000118420.1
ENSMUST00000154358.1
ENSMUST00000121339.1
ENSMUST00000119604.1
ENSMUST00000136108.1
ENSMUST00000121813.1
ENSMUST00000119985.1
ENSMUST00000138812.1
 Mrps17









mitochondrial ribosomal protein S17









chr18_-_43438280 0.050 ENSMUST00000121805.1
 Dpysl3
dihydropyrimidinase-like 3
chr6_+_113392417 0.043 ENSMUST00000032414.4
ENSMUST00000038889.5
 Ttll3

tubulin tyrosine ligase-like family, member 3

chr19_-_11336107 0.041 ENSMUST00000056035.2
ENSMUST00000067532.4
 Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr9_+_44398176 0.040 ENSMUST00000165839.1
 Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr11_-_116027961 0.035 ENSMUST00000106454.1
 H3f3b
H3 histone, family 3B
chr9_+_72806874 0.029 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chrX_+_159627265 0.027 ENSMUST00000112456.2
 Sh3kbp1
SH3-domain kinase binding protein 1
chr13_+_21495218 0.019 ENSMUST00000104942.1
 AK157302
cDNA sequence AK157302
chr5_+_34525797 0.016 ENSMUST00000125817.1
ENSMUST00000067638.7
 Sh3bp2

SH3-domain binding protein 2

chrX_+_112604274 0.011 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chr18_+_80206775 0.010 ENSMUST00000125127.1
ENSMUST00000025463.7
ENSMUST00000145963.1
ENSMUST00000025464.7
 Gm16286

Txnl4a

predicted gene 16286

thioredoxin-like 4A

chr18_+_80206887 0.009 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chrX_-_139871637 0.006 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 10.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 0.8 GO:0050915 sensory perception of sour taste(GO:0050915)
0.2 1.2 GO:0015671 oxygen transport(GO:0015671)
0.2 0.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.3 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 1.1 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.2 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.2 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.3 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.0 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.0 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) phosphate ion transmembrane transport(GO:0035435)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 10.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.3 1.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.8 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 1.1 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)