Motif ID: Mef2c

Z-value: 0.742


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83504032_83504050-0.521.2e-02Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 171 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_34528844 4.705 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr4_+_144892813 3.197 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 2.662 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_69785507 2.498 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr3_-_85722474 2.363 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr4_+_144893127 2.302 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr5_+_66745835 1.864 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr19_-_5802640 1.791 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr7_+_112742025 1.771 ENSMUST00000164363.1
 Tead1
TEA domain family member 1
chr14_+_101840602 1.673 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_+_101840501 1.669 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr6_+_112273758 1.493 ENSMUST00000032376.5
 Lmcd1
LIM and cysteine-rich domains 1
chr13_+_16011851 1.488 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chrX_-_51681856 1.469 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681703 1.430 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr2_-_77703252 1.424 ENSMUST00000171063.1
 Zfp385b
zinc finger protein 385B
chr1_-_64122256 1.412 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr6_+_108213086 1.275 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr5_-_122002340 1.220 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr4_+_46039202 1.065 ENSMUST00000156200.1
 Tmod1
tropomodulin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.2 GO:0042572 retinol metabolic process(GO:0042572)
0.5 4.7 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.4 4.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.5 2.9 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 2.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.2 2.0 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.4 1.8 GO:0035063 nuclear speck organization(GO:0035063)
0.2 1.8 GO:0014883 transition between fast and slow fiber(GO:0014883) positive regulation of stem cell population maintenance(GO:1902459)
0.1 1.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 1.4 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.0 1.4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.2 1.3 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 1.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 1.2 GO:0007614 short-term memory(GO:0007614)
0.2 1.1 GO:0031033 myosin filament organization(GO:0031033)
0.1 1.1 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.0 GO:0030091 protein repair(GO:0030091)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0035097 histone methyltransferase complex(GO:0035097)
0.2 4.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 1.5 GO:0043512 inhibin A complex(GO:0043512)
0.1 1.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.4 GO:0032587 ruffle membrane(GO:0032587)
0.4 1.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 1.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.8 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.8 GO:0010369 chromocenter(GO:0010369)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0014802 terminal cisterna(GO:0014802)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 4.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 4.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 3.4 GO:0042805 actinin binding(GO:0042805)
0.1 2.9 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.3 2.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 1.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 1.1 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.0 GO:0019534 toxin transporter activity(GO:0019534)
0.1 1.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 1.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.9 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.7 GO:0102391 decanoate--CoA ligase activity(GO:0102391)