Motif ID: Mef2c
Z-value: 0.742
Transcription factors associated with Mef2c:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Mef2c | ENSMUSG00000005583.10 | Mef2c |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Mef2c | mm10_v2_chr13_+_83504032_83504050 | -0.52 | 1.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 8.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.5 | 2.9 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
0.5 | 4.7 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
0.4 | 1.8 | GO:0035063 | nuclear speck organization(GO:0035063) |
0.4 | 4.3 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.3 | 1.5 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
0.3 | 0.8 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
0.2 | 1.1 | GO:0031033 | myosin filament organization(GO:0031033) |
0.2 | 0.8 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
0.2 | 1.0 | GO:0030091 | protein repair(GO:0030091) |
0.2 | 0.6 | GO:0070375 | ERK5 cascade(GO:0070375) |
0.2 | 2.0 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
0.2 | 0.7 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
0.2 | 1.8 | GO:0014883 | transition between fast and slow fiber(GO:0014883) positive regulation of stem cell population maintenance(GO:1902459) |
0.2 | 1.3 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
0.2 | 0.9 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
0.2 | 0.3 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
0.1 | 1.1 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
0.1 | 0.7 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
0.1 | 0.6 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
0.1 | 0.3 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
0.1 | 0.3 | GO:0007525 | somatic muscle development(GO:0007525) |
0.1 | 1.0 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.1 | 1.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.1 | 0.3 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
0.1 | 1.4 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
0.1 | 0.3 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
0.1 | 0.3 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
0.1 | 0.6 | GO:0015862 | uridine transport(GO:0015862) |
0.1 | 0.3 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
0.1 | 1.8 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.1 | 0.4 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
0.1 | 0.6 | GO:2000809 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809) |
0.1 | 0.5 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
0.1 | 1.2 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
0.1 | 0.8 | GO:0080009 | mRNA methylation(GO:0080009) |
0.1 | 0.3 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
0.1 | 1.1 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
0.1 | 1.2 | GO:0007614 | short-term memory(GO:0007614) |
0.0 | 0.3 | GO:0015840 | urea transport(GO:0015840) urea transmembrane transport(GO:0071918) |
0.0 | 0.4 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.0 | 0.7 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.0 | 0.4 | GO:1901409 | regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
0.0 | 0.3 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
0.0 | 0.1 | GO:0055118 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of cardiac muscle contraction(GO:0055118) negative regulation of mucus secretion(GO:0070256) |
0.0 | 0.4 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.0 | 0.2 | GO:0042538 | hyperosmotic salinity response(GO:0042538) |
0.0 | 0.4 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
0.0 | 1.0 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
0.0 | 0.2 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.0 | 0.1 | GO:0002024 | diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845) |
0.0 | 0.1 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
0.0 | 0.4 | GO:0030813 | positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) |
0.0 | 0.3 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
0.0 | 0.3 | GO:0097341 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
0.0 | 0.1 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) positive regulation of hyaluronan biosynthetic process(GO:1900127) |
0.0 | 1.0 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
0.0 | 0.1 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
0.0 | 0.3 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
0.0 | 0.2 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
0.0 | 0.4 | GO:0007097 | nuclear migration(GO:0007097) |
0.0 | 0.9 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
0.0 | 0.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 1.4 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
0.0 | 2.5 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
0.0 | 0.1 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
0.0 | 0.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0043512 | inhibin A complex(GO:0043512) |
0.4 | 1.3 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
0.2 | 4.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.1 | 0.8 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
0.1 | 0.6 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.1 | 0.3 | GO:0014802 | terminal cisterna(GO:0014802) |
0.1 | 0.6 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.1 | 0.3 | GO:0090537 | CERF complex(GO:0090537) |
0.1 | 0.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
0.1 | 1.4 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.1 | 5.1 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
0.0 | 1.1 | GO:0005865 | striated muscle thin filament(GO:0005865) |
0.0 | 0.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.0 | 0.8 | GO:0010369 | chromocenter(GO:0010369) |
0.0 | 2.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.0 | 0.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.0 | 0.2 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.0 | 0.4 | GO:0005614 | interstitial matrix(GO:0005614) |
0.0 | 0.2 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
0.0 | 0.3 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.8 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.3 | GO:0043194 | axon initial segment(GO:0043194) |
0.0 | 0.7 | GO:0031941 | filamentous actin(GO:0031941) |
0.0 | 0.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 1.4 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.6 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
0.0 | 2.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
0.0 | 0.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 0.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 8.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.4 | 1.3 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.3 | 2.1 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.2 | 4.1 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.2 | 0.5 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
0.1 | 4.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.1 | 0.6 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
0.1 | 1.8 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.1 | 1.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.1 | 1.0 | GO:0019534 | toxin transporter activity(GO:0019534) |
0.1 | 0.3 | GO:0070615 | nucleosome-dependent ATPase activity(GO:0070615) |
0.1 | 3.4 | GO:0042805 | actinin binding(GO:0042805) |
0.1 | 1.0 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
0.1 | 0.3 | GO:0098634 | protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639) |
0.1 | 2.9 | GO:0034930 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131) |
0.1 | 0.4 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
0.1 | 1.0 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.1 | 1.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.1 | 0.8 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
0.1 | 1.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
0.1 | 0.6 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.1 | 0.5 | GO:0043495 | protein anchor(GO:0043495) |
0.1 | 0.3 | GO:0070644 | vitamin D response element binding(GO:0070644) |
0.1 | 0.3 | GO:0015265 | urea channel activity(GO:0015265) |
0.1 | 0.6 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
0.0 | 0.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.7 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
0.0 | 0.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.0 | 0.7 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
0.0 | 0.6 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
0.0 | 0.6 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.0 | 0.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.0 | 0.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 0.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.0 | 0.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.0 | 0.2 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
0.0 | 0.1 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
0.0 | 0.4 | GO:0001968 | fibronectin binding(GO:0001968) |
0.0 | 0.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
0.0 | 0.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.2 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.0 | 0.4 | GO:0032452 | histone demethylase activity(GO:0032452) |