Motif ID: Mef2d_Mef2a

Z-value: 0.636

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2dmm10_v2_chr3_+_88142536_881425720.405.8e-02Click!
Mef2amm10_v2_chr7_-_67372846_673728580.262.3e-01Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 2.123 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_+_24985840 1.390 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr9_-_112232449 1.191 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr5_-_128953303 1.089 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr4_+_46039202 0.946 ENSMUST00000156200.1
 Tmod1
tropomodulin 1
chr9_+_34904913 0.915 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr2_-_172043466 0.897 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr13_+_83573577 0.868 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr9_+_104566677 0.868 ENSMUST00000157006.1
 Cpne4
copine IV
chr6_-_136171722 0.769 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr18_-_25753852 0.742 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chr18_+_60963517 0.733 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr1_-_12991109 0.727 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr13_+_5861489 0.717 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr19_+_38264761 0.640 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr15_+_101266839 0.621 ENSMUST00000023779.6
 Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr6_+_137410721 0.620 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr1_-_64122256 0.578 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr6_+_55336424 0.534 ENSMUST00000004774.3
 Aqp1
aquaporin 1
chr1_-_172329261 0.531 ENSMUST00000062387.2
 Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 2.0 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.3 0.9 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.3 0.9 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 0.9 GO:0031033 myosin filament organization(GO:0031033)
0.2 0.9 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.2 0.9 GO:0045657 positive regulation of monocyte differentiation(GO:0045657) cellular response to potassium ion starvation(GO:0051365)
0.0 0.9 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 0.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 0.7 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.7 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.1 0.7 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.6 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.1 0.6 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.5 GO:0046878 establishment or maintenance of actin cytoskeleton polarity(GO:0030950) positive regulation of saliva secretion(GO:0046878) cellular response to copper ion(GO:0071280)
0.1 0.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.5 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0097440 apical dendrite(GO:0097440)
0.0 1.5 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 1.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 0.5 GO:0000802 transverse filament(GO:0000802)
0.1 0.5 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.5 GO:0016459 myosin complex(GO:0016459)
0.1 0.4 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.3 GO:0090537 CERF complex(GO:0090537)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.2 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.1 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.0 GO:0030275 LRR domain binding(GO:0030275)
0.1 0.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.7 GO:0043531 ADP binding(GO:0043531)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.5 GO:0015168 glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)