Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 0.595

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx6mm10_v2_chr2_-_36105271_36105434-0.612.1e-03Click!
Lmx1amm10_v2_chr1_+_167689552_1676895630.406.1e-02Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 3.541 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr5_+_139543889 3.449 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_72986716 2.422 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr8_-_61902669 2.307 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr2_+_20737306 1.626 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr3_+_125404072 1.531 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_125404292 1.409 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr7_-_49636847 1.304 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr6_+_8948608 1.194 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr17_+_17402672 1.142 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr4_-_35845204 1.045 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr1_-_172027269 0.958 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr8_+_45658666 0.889 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 0.873 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr10_-_6980376 0.844 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr4_-_97778042 0.843 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr3_+_159839729 0.806 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr2_+_25372315 0.804 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr1_-_172027251 0.781 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr3_-_116253467 0.737 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 2.9 GO:0043010 camera-type eye development(GO:0043010)
0.2 2.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 2.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6 1.7 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 1.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.2 1.0 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.1 1.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.9 GO:0060539 diaphragm development(GO:0060539)
0.3 0.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.8 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.2 0.7 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.2 0.7 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.7 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.7 GO:0007530 sex determination(GO:0007530)
0.0 0.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0002102 podosome(GO:0002102)
0.4 1.7 GO:0060187 cell pole(GO:0060187)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.8 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.6 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.4 GO:0008623 CHRAC(GO:0008623)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 0.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.2 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 0.2 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 0.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.7 GO:0048185 activin binding(GO:0048185)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.6 GO:0017091 AU-rich element binding(GO:0017091)
0.2 0.5 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.5 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.1 0.4 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.4 GO:0005542 folic acid binding(GO:0005542)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)