Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 1.014

Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6:

Gene SymbolEntrez IDGene Name
Barx1 ENSMUSG00000021381.4 Barx1
Dlx6 ENSMUSG00000029754.7 Dlx6
Lhx9 ENSMUSG00000019230.8 Lhx9
Msx1 ENSMUSG00000048450.10 Msx1
Rax ENSMUSG00000024518.3 Rax

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx9mm10_v2_chr1_-_138848576_138848603-0.844.4e-07Click!
Msx1mm10_v2_chr5_-_37824580_378245840.521.1e-02Click!
Dlx6mm10_v2_chr6_+_6863769_68637970.321.3e-01Click!
Raxmm10_v2_chr18_-_65939048_659390890.029.4e-01Click!


Activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6.

activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6


Sorted Z-values histogram for motif Msx1_Lhx9_Barx1_Rax_Dlx6

Sorted Z-values for motif Msx1_Lhx9_Barx1_Rax_Dlx6



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_134747241 13.469 ENSMUST00000015138.9
 Eln
elastin
chr3_-_49757257 10.085 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr2_+_116067213 9.432 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr16_+_42907563 8.282 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr5_-_62766153 7.464 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_116067391 6.899 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr11_-_98053415 6.124 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr14_-_118052235 5.398 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr9_-_40346290 5.256 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr2_-_77703252 5.133 ENSMUST00000171063.1
 Zfp385b
zinc finger protein 385B
chr1_+_104768510 4.837 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr12_-_83487708 4.833 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr3_+_66219909 4.689 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr19_+_26749726 4.521 ENSMUST00000175842.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr16_-_37384915 4.389 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr13_+_44121167 3.639 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr3_+_86070915 3.359 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr6_+_125552948 3.256 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr1_-_190170671 3.198 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr16_-_37384940 3.104 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.8 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.5 10.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 8.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 7.5 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.6 5.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.8 5.4 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 5.0 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
1.6 4.8 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
1.6 4.7 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0 4.6 GO:0098792 xenophagy(GO:0098792)
0.8 3.9 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.8 3.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.6 3.4 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 3.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 3.1 GO:0030168 platelet activation(GO:0030168)
0.0 3.1 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 2.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.7 2.0 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 2.0 GO:0048305 immunoglobulin secretion(GO:0048305)
1.8 1.8 GO:0060915 fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 13.5 GO:0071953 elastic fiber(GO:0071953)
0.4 10.4 GO:0071565 nBAF complex(GO:0071565)
0.1 7.5 GO:0031201 SNARE complex(GO:0031201)
0.1 4.1 GO:0097440 apical dendrite(GO:0097440)
0.2 3.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 3.4 GO:0043205 fibril(GO:0043205)
0.7 3.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.6 GO:0000124 SAGA complex(GO:0000124)
0.1 1.5 GO:0043083 synaptic cleft(GO:0043083)
0.5 1.4 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 1.4 GO:0097433 dense body(GO:0097433)
0.1 1.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.9 GO:0030673 axolemma(GO:0030673)
0.3 0.8 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 9.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 7.5 GO:0019905 syntaxin binding(GO:0019905)
0.1 6.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.4 5.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.6 4.8 GO:0050693 LBD domain binding(GO:0050693)
0.5 4.8 GO:0019865 immunoglobulin binding(GO:0019865)
0.9 4.7 GO:0001849 complement component C1q binding(GO:0001849)
0.1 4.6 GO:0002039 p53 binding(GO:0002039)
0.0 4.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 3.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.4 3.4 GO:0001618 virus receptor activity(GO:0001618)
0.1 3.4 GO:0070064 proline-rich region binding(GO:0070064)
0.1 3.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 3.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 2.4 GO:0001968 fibronectin binding(GO:0001968)
0.4 1.8 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 1.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 1.5 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)