Motif ID: Msx2_Hoxd4

Z-value: 1.376

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.116.2e-01Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 164 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_190170671 11.981 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr5_-_62766153 11.710 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_190170178 9.844 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr6_-_36811361 8.752 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr3_+_62419668 6.700 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr2_-_63184253 6.565 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr3_-_49757257 6.503 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr3_-_85741389 5.675 ENSMUST00000094148.4
 Fam160a1
family with sequence similarity 160, member A1
chr2_+_4017727 5.562 ENSMUST00000177457.1
 Frmd4a
FERM domain containing 4A
chr1_-_163725123 5.220 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr2_-_63184170 4.485 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr14_-_88471396 4.249 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr1_+_165788681 3.572 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr9_+_22454290 3.008 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr3_+_68869563 2.958 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr5_-_62765618 2.917 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_165788746 2.726 ENSMUST00000161559.2
 Cd247
CD247 antigen
chr15_-_79285502 2.588 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr1_-_163289214 2.515 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr3_-_66296807 2.258 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.3 21.8 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 11.1 GO:0051291 protein heterooligomerization(GO:0051291)
2.9 8.8 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 6.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.3 6.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 6.1 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 5.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 5.2 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 4.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 2.9 GO:0051764 actin crosslink formation(GO:0051764)
0.2 2.5 GO:0048664 neuron fate determination(GO:0048664)
0.0 2.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 2.2 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 2.2 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.1 2.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 2.1 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 2.0 GO:0071398 cellular response to fatty acid(GO:0071398)
0.5 1.8 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.3 1.8 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.6 1.7 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 8.8 GO:0031594 neuromuscular junction(GO:0031594)
1.6 6.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 5.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.8 GO:0070469 respiratory chain(GO:0070469)
0.3 2.6 GO:0071439 clathrin complex(GO:0071439)
0.0 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 1.7 GO:0070688 MLL5-L complex(GO:0070688)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.5 1.4 GO:0072534 perineuronal net(GO:0072534)
0.0 1.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 0.9 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.9 GO:0044327 dendritic spine head(GO:0044327)
0.2 0.7 GO:0031251 PAN complex(GO:0031251)
0.1 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.7 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 21.8 GO:0050693 LBD domain binding(GO:0050693)
0.3 14.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 12.3 GO:0005509 calcium ion binding(GO:0005509)
0.6 11.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
2.9 8.8 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 5.6 GO:0030674 protein binding, bridging(GO:0030674)
0.1 5.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 4.7 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 2.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.0 GO:0016594 glycine binding(GO:0016594)
0.1 2.0 GO:0005504 fatty acid binding(GO:0005504)
0.0 2.0 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.6 1.7 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 1.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.5 1.4 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.2 1.4 GO:0097322 7SK snRNA binding(GO:0097322)