Motif ID: Mtf1

Z-value: 1.066


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.048.5e-01Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 16.273 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr8_+_94179089 10.173 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr11_-_32222233 7.095 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr6_-_39118211 2.627 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr9_-_56635624 2.253 ENSMUST00000114256.1
 Lingo1
leucine rich repeat and Ig domain containing 1
chr9_-_112187898 1.766 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr12_-_4592927 1.737 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr4_+_129985098 1.635 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr1_+_135729147 1.593 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr4_+_129984833 1.575 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr14_-_26170283 1.399 ENSMUST00000100809.4
 Plac9b
placenta specific 9b
chr9_-_14381242 1.378 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr3_-_94412883 1.364 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr1_+_167618246 1.345 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr9_+_78175898 1.320 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr7_+_5056856 1.223 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr17_+_47688992 1.191 ENSMUST00000156118.1
 Frs3
fibroblast growth factor receptor substrate 3
chr10_+_70245083 1.148 ENSMUST00000046807.6
 Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr2_-_91236967 1.110 ENSMUST00000028696.4
 Ddb2
damage specific DNA binding protein 2
chr2_-_91236877 1.025 ENSMUST00000111352.1
 Ddb2
damage specific DNA binding protein 2
chr8_+_123373778 0.981 ENSMUST00000057934.3
ENSMUST00000108840.2
 Tcf25

transcription factor 25 (basic helix-loop-helix)

chr11_+_63133068 0.938 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr10_+_77606571 0.921 ENSMUST00000099538.5
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr15_-_58214882 0.904 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr12_+_33957645 0.842 ENSMUST00000049089.5
 Twist1
twist basic helix-loop-helix transcription factor 1
chr3_+_107895916 0.814 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr16_-_91597636 0.766 ENSMUST00000023686.8
 Tmem50b
transmembrane protein 50B
chr1_-_166002613 0.731 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr3_+_107895821 0.719 ENSMUST00000004134.4
 Gstm5
glutathione S-transferase, mu 5
chr2_-_130664565 0.708 ENSMUST00000089559.4
 Ddrgk1
DDRGK domain containing 1
chr17_-_56716788 0.684 ENSMUST00000067931.5
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr7_+_132610620 0.646 ENSMUST00000033241.5
 Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr1_+_131867224 0.633 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr3_+_107896247 0.628 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr12_+_103532435 0.599 ENSMUST00000021631.5
 Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr5_-_125341043 0.597 ENSMUST00000111390.1
ENSMUST00000086075.6
 Scarb1

scavenger receptor class B, member 1

chr10_+_77606217 0.584 ENSMUST00000129492.1
ENSMUST00000141228.2
 Sumo3

SMT3 suppressor of mif two 3 homolog 3 (yeast)

chr11_+_63132569 0.534 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr8_-_70776650 0.532 ENSMUST00000034296.8
 Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr17_-_56626872 0.505 ENSMUST00000047226.8
 Lonp1
lon peptidase 1, mitochondrial
chr9_+_57940104 0.505 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr1_+_179668202 0.467 ENSMUST00000040538.3
 Sccpdh
saccharopine dehydrogenase (putative)
chr3_-_58692391 0.432 ENSMUST00000070368.7
 Siah2
seven in absentia 2
chr6_-_56923927 0.416 ENSMUST00000031793.5
 Nt5c3
5'-nucleotidase, cytosolic III
chr8_+_13159135 0.410 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr10_+_77606044 0.399 ENSMUST00000020501.8
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr13_-_45964964 0.392 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
 Atxn1


ataxin 1


chr1_-_166002591 0.380 ENSMUST00000111429.4
ENSMUST00000176800.1
 Pou2f1

POU domain, class 2, transcription factor 1

chr7_-_109865586 0.377 ENSMUST00000007423.5
ENSMUST00000106728.2
ENSMUST00000106729.1
 Scube2


signal peptide, CUB domain, EGF-like 2


chr5_-_34637203 0.373 ENSMUST00000114331.3
 Mfsd10
major facilitator superfamily domain containing 10
chr10_-_81001338 0.372 ENSMUST00000099462.1
ENSMUST00000118233.1
 Gng7

guanine nucleotide binding protein (G protein), gamma 7

chr19_-_4839286 0.363 ENSMUST00000037246.5
 Ccs
copper chaperone for superoxide dismutase
chr4_+_134496996 0.343 ENSMUST00000095074.3
 Paqr7
progestin and adipoQ receptor family member VII
chr1_+_157412352 0.282 ENSMUST00000061537.5
 2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr19_-_4615647 0.281 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr4_-_93335510 0.266 ENSMUST00000066774.4
 Tusc1
tumor suppressor candidate 1
chr5_+_30869579 0.264 ENSMUST00000046349.7
 Tmem214
transmembrane protein 214
chr3_-_121815212 0.259 ENSMUST00000029770.5
 Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr11_+_99047311 0.240 ENSMUST00000140772.1
 Igfbp4
insulin-like growth factor binding protein 4
chr5_+_115506668 0.228 ENSMUST00000067268.8
ENSMUST00000086523.3
 Pxn

paxillin

chr1_-_167393826 0.228 ENSMUST00000028005.2
 Mgst3
microsomal glutathione S-transferase 3
chr8_+_106210936 0.199 ENSMUST00000071592.5
 Prmt7
protein arginine N-methyltransferase 7
chr10_+_20952547 0.199 ENSMUST00000105525.4
 Ahi1
Abelson helper integration site 1
chr8_+_106211016 0.195 ENSMUST00000109297.1
 Prmt7
protein arginine N-methyltransferase 7
chr19_-_4615453 0.190 ENSMUST00000053597.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr5_+_30869623 0.187 ENSMUST00000114716.1
 Tmem214
transmembrane protein 214
chr10_-_39899238 0.168 ENSMUST00000178563.1
 AA474331
expressed sequence AA474331
chr8_+_92827273 0.166 ENSMUST00000034187.7
 Mmp2
matrix metallopeptidase 2
chr5_-_34637107 0.160 ENSMUST00000124668.1
ENSMUST00000001109.4
ENSMUST00000155577.1
ENSMUST00000114329.1
 Mfsd10



major facilitator superfamily domain containing 10



chr15_-_83149307 0.148 ENSMUST00000100375.4
 Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr8_+_70905970 0.122 ENSMUST00000019405.2
 Map1s
microtubule-associated protein 1S
chr7_+_119793987 0.119 ENSMUST00000033218.8
ENSMUST00000106520.1
 2610020H08Rik

RIKEN cDNA 2610020H08 gene

chr5_+_105415738 0.105 ENSMUST00000112707.1
 Lrrc8b
leucine rich repeat containing 8 family, member B
chr18_+_14424821 0.104 ENSMUST00000069552.5
 Gm5160
predicted gene 5160
chr8_-_106210924 0.088 ENSMUST00000035925.5
 Slc7a6os
solute carrier family 7, member 6 opposite strand
chr12_+_24572276 0.087 ENSMUST00000085553.5
 Grhl1
grainyhead-like 1 (Drosophila)
chr15_+_100469034 0.078 ENSMUST00000037001.8
 Letmd1
LETM1 domain containing 1
chr19_-_41263931 0.068 ENSMUST00000025989.8
 Tm9sf3
transmembrane 9 superfamily member 3
chr7_-_141539784 0.050 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
 Chid1



chitinase domain containing 1



chr9_+_109832998 0.041 ENSMUST00000119376.1
ENSMUST00000122343.1
 Nme6

NME/NM23 nucleoside diphosphate kinase 6

chr2_-_173119402 0.022 ENSMUST00000094287.3
ENSMUST00000179693.1
 Ctcfl

CCCTC-binding factor (zinc finger protein)-like

chr16_-_22857514 0.012 ENSMUST00000004576.6
 Tbccd1
TBCC domain containing 1
chr2_+_91237110 0.012 ENSMUST00000181191.1
 A330069E16Rik
RIKEN cDNA A330069E16 gene
chr2_-_119787504 0.001 ENSMUST00000110793.1
ENSMUST00000099529.2
ENSMUST00000048493.5
 Rpap1


RNA polymerase II associated protein 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 26.4 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.3 2.2 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.3 0.9 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 0.8 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.3 2.1 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.2 0.6 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.2 1.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 0.4 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.1 2.3 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.1 0.7 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 1.1 GO:0046415 urate metabolic process(GO:0046415)
0.1 7.1 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 0.5 GO:0042891 antibiotic transport(GO:0042891)
0.1 1.9 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.3 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 1.5 GO:0032060 bleb assembly(GO:0032060)
0.1 0.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.2 GO:0030862 regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.1 0.5 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 1.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.4 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.5 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.4 GO:0019430 removal of superoxide radicals(GO:0019430)
0.0 1.6 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.1 GO:0002934 desmosome organization(GO:0002934)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 1.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.2 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 0.7 GO:0045098 type III intermediate filament(GO:0045098)
0.2 2.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.4 GO:0044194 cytolytic granule(GO:0044194)
0.1 1.5 GO:0043218 compact myelin(GO:0043218)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 7.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 9.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 10.5 GO:0005507 copper ion binding(GO:0005507)
0.1 1.9 GO:0031386 protein tag(GO:0031386)
0.1 1.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.4 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 2.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.5 GO:0042895 antibiotic transporter activity(GO:0042895)
0.1 7.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.2 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 1.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.7 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.4 GO:0034046 poly(G) binding(GO:0034046)
0.0 2.1 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)
0.0 0.5 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) NADPH:sulfur oxidoreductase activity(GO:0043914) epoxyqueuosine reductase activity(GO:0052693)
0.0 15.8 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.4 GO:0004519 endonuclease activity(GO:0004519)