Motif ID: Nfat5

Z-value: 0.762


Transcription factors associated with Nfat5:

Gene SymbolEntrez IDGene Name
Nfat5 ENSMUSG00000003847.10 Nfat5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293500_1072935590.321.3e-01Click!


Activity profile for motif Nfat5.

activity profile for motif Nfat5


Sorted Z-values histogram for motif Nfat5

Sorted Z-values for motif Nfat5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfat5

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 4.733 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr14_-_101609033 4.210 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr7_-_97417730 2.670 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr4_-_82505707 2.421 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr4_-_82505749 2.139 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr14_+_17660956 1.941 ENSMUST00000022303.7
ENSMUST00000091471.4
 Thrb

thyroid hormone receptor beta

chr5_-_104021919 1.922 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr6_+_120773633 1.769 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr5_-_104021799 1.635 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr5_+_139423151 1.434 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr7_-_80402743 1.357 ENSMUST00000122232.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr5_-_148392810 1.340 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr5_-_124354671 1.327 ENSMUST00000031341.4
 Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr10_-_95415484 1.251 ENSMUST00000172070.1
ENSMUST00000150432.1
 Socs2

suppressor of cytokine signaling 2

chr11_+_102836296 1.245 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr2_-_30415302 1.185 ENSMUST00000132981.2
ENSMUST00000129494.1
 Crat

carnitine acetyltransferase

chr5_+_90772435 1.133 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr15_-_75894474 1.063 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr7_+_99535652 1.058 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr10_-_95415283 1.054 ENSMUST00000119917.1
 Socs2
suppressor of cytokine signaling 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0007528 neuromuscular junction development(GO:0007528)
1.1 4.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.5 4.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.4 3.6 GO:0042447 hormone catabolic process(GO:0042447)
0.4 3.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 2.7 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.1 2.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 2.1 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.6 1.9 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.2 1.6 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)
0.5 1.4 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.3 1.4 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2 1.3 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0 1.3 GO:0060325 face morphogenesis(GO:0060325)
0.3 1.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.2 1.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.3 0.8 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.8 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2 0.7 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.2 0.6 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 GO:0031594 neuromuscular junction(GO:0031594)
0.2 4.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 3.6 GO:0005811 lipid particle(GO:0005811)
0.0 3.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.6 GO:0031143 pseudopodium(GO:0031143)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.4 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.1 1.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.1 GO:0031091 platelet alpha granule(GO:0031091)
0.0 1.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.8 GO:0042629 mast cell granule(GO:0042629)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 4.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 4.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 3.6 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.8 3.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.5 2.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 2.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 1.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.5 1.6 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 1.4 GO:1990239 steroid hormone binding(GO:1990239)
0.2 1.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 1.3 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.1 1.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.4 1.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 1.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.0 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.8 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.1 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)