Motif ID: Nfat5

Z-value: 0.762


Transcription factors associated with Nfat5:

Gene SymbolEntrez IDGene Name
Nfat5 ENSMUSG00000003847.10 Nfat5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293500_1072935590.321.3e-01Click!


Activity profile for motif Nfat5.

activity profile for motif Nfat5


Sorted Z-values histogram for motif Nfat5

Sorted Z-values for motif Nfat5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfat5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_101377897 4.733 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr14_-_101609033 4.210 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr7_-_97417730 2.670 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr4_-_82505707 2.421 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr4_-_82505749 2.139 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr14_+_17660956 1.941 ENSMUST00000022303.7
ENSMUST00000091471.4
 Thrb

thyroid hormone receptor beta

chr5_-_104021919 1.922 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr6_+_120773633 1.769 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr5_-_104021799 1.635 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr5_+_139423151 1.434 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr7_-_80402743 1.357 ENSMUST00000122232.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr5_-_148392810 1.340 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr5_-_124354671 1.327 ENSMUST00000031341.4
 Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr10_-_95415484 1.251 ENSMUST00000172070.1
ENSMUST00000150432.1
 Socs2

suppressor of cytokine signaling 2

chr11_+_102836296 1.245 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr2_-_30415302 1.185 ENSMUST00000132981.2
ENSMUST00000129494.1
 Crat

carnitine acetyltransferase

chr5_+_90772435 1.133 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr15_-_75894474 1.063 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr7_+_99535652 1.058 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr10_-_95415283 1.054 ENSMUST00000119917.1
 Socs2
suppressor of cytokine signaling 2
chr2_-_30415389 1.041 ENSMUST00000142096.1
 Crat
carnitine acetyltransferase
chr1_+_24678536 0.951 ENSMUST00000095062.3
 Lmbrd1
LMBR1 domain containing 1
chr15_-_98881255 0.948 ENSMUST00000024518.9
 Rhebl1
Ras homolog enriched in brain like 1
chr7_-_46958475 0.937 ENSMUST00000094398.4
 Uevld
UEV and lactate/malate dehyrogenase domains
chr2_-_30415509 0.911 ENSMUST00000134120.1
ENSMUST00000102854.3
 Crat

carnitine acetyltransferase

chr11_-_88863717 0.816 ENSMUST00000107904.2
 Akap1
A kinase (PRKA) anchor protein 1
chrX_+_139684980 0.805 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr10_-_62507737 0.775 ENSMUST00000020271.6
 Srgn
serglycin
chr15_-_38078842 0.715 ENSMUST00000110336.2
 Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr18_+_36559972 0.705 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr9_-_13446753 0.659 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr5_-_69592311 0.643 ENSMUST00000031117.6
 Gnpda2
glucosamine-6-phosphate deaminase 2
chr10_-_78352053 0.612 ENSMUST00000105388.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr10_-_78351690 0.583 ENSMUST00000166360.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr4_+_110397764 0.582 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr12_-_86079019 0.555 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr7_-_126625676 0.549 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chr4_+_110397661 0.537 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr17_+_43389436 0.535 ENSMUST00000113599.1
 Gpr116
G protein-coupled receptor 116
chr7_+_99535439 0.528 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr7_+_6371364 0.514 ENSMUST00000086323.4
ENSMUST00000108559.2
 Zfp78

zinc finger protein 78

chr8_-_107403197 0.507 ENSMUST00000003947.8
 Nqo1
NAD(P)H dehydrogenase, quinone 1
chr3_-_129755305 0.495 ENSMUST00000029653.2
 Egf
epidermal growth factor
chr18_+_36560581 0.489 ENSMUST00000155329.2
 Ankhd1
ankyrin repeat and KH domain containing 1
chr10_+_84622365 0.485 ENSMUST00000077175.5
 Polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr10_-_78352212 0.468 ENSMUST00000146899.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr4_-_138396438 0.464 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr10_-_78351711 0.452 ENSMUST00000105390.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr3_-_98724543 0.437 ENSMUST00000107022.1
ENSMUST00000107021.1
 Hsd3b2

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

chr19_-_5845471 0.423 ENSMUST00000174287.1
ENSMUST00000173672.1
 Neat1

nuclear paraspeckle assembly transcript 1 (non-protein coding)

chr9_-_71771535 0.411 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
 Cgnl1


cingulin-like 1


chr2_+_68117713 0.401 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr6_-_142964404 0.401 ENSMUST00000032421.3
 St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr16_-_55838827 0.368 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr3_-_69004565 0.365 ENSMUST00000169064.1
 Ift80
intraflagellar transport 80
chr8_-_46124146 0.327 ENSMUST00000170416.1
 Snx25
sorting nexin 25
chrX_-_155216338 0.302 ENSMUST00000112551.3
 Sat1
spermidine/spermine N1-acetyl transferase 1
chr9_+_92457369 0.281 ENSMUST00000034941.7
 Plscr4
phospholipid scramblase 4
chr12_+_98920567 0.267 ENSMUST00000085109.3
ENSMUST00000079146.6
 Ttc8

tetratricopeptide repeat domain 8

chr4_+_141444654 0.241 ENSMUST00000006377.6
 Zbtb17
zinc finger and BTB domain containing 17
chr17_+_91236787 0.234 ENSMUST00000057074.8
 Gm6741
predicted gene 6741
chr2_-_177925604 0.218 ENSMUST00000108934.2
ENSMUST00000081529.4
 C330013J21Rik

RIKEN cDNA C330013J21 gene

chrX_-_155216444 0.210 ENSMUST00000026318.8
 Sat1
spermidine/spermine N1-acetyl transferase 1
chr1_+_83159733 0.206 ENSMUST00000113436.1
ENSMUST00000065436.3
ENSMUST00000065403.6
 Daw1


dynein assembly factor with WDR repeat domains 1


chr13_+_44840686 0.192 ENSMUST00000173906.1
 Jarid2
jumonji, AT rich interactive domain 2
chr6_+_91684061 0.191 ENSMUST00000032185.7
 Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chrX_+_74429671 0.180 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
 Ikbkg


inhibitor of kappaB kinase gamma


chr13_+_73626886 0.177 ENSMUST00000022104.7
 Tert
telomerase reverse transcriptase
chr11_-_118401826 0.168 ENSMUST00000106290.3
ENSMUST00000043722.3
 Lgals3bp

lectin, galactoside-binding, soluble, 3 binding protein

chr7_-_81493725 0.151 ENSMUST00000119121.1
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr19_+_10525244 0.137 ENSMUST00000038379.3
 Cpsf7
cleavage and polyadenylation specific factor 7
chr10_+_21994666 0.128 ENSMUST00000020145.5
 Sgk1
serum/glucocorticoid regulated kinase 1
chr7_-_141918481 0.125 ENSMUST00000151890.1
 Tollip
toll interacting protein
chr6_-_92183972 0.115 ENSMUST00000140438.1
 Mrps25
mitochondrial ribosomal protein S25
chr9_-_7835255 0.070 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr7_+_6474088 0.069 ENSMUST00000056144.5
 Olfr1346
olfactory receptor 1346
chr12_+_102948843 0.069 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr15_+_5185700 0.066 ENSMUST00000081640.5
 Ttc33
tetratricopeptide repeat domain 33
chr16_+_27389911 0.025 ENSMUST00000143823.1
 Ccdc50
coiled-coil domain containing 50
chr10_-_7663569 0.022 ENSMUST00000162606.1
 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr7_-_43533171 0.006 ENSMUST00000004728.5
ENSMUST00000039861.5
 Cd33

CD33 antigen


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.6 1.9 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.5 1.4 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.5 4.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.4 3.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.4 3.6 GO:0042447 hormone catabolic process(GO:0042447)
0.3 1.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 1.4 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.3 0.8 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.2 0.7 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.2 1.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.2 1.6 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 1.3 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.2 0.6 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.2 0.5 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 0.5 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 2.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.6 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.1 0.8 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 2.7 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.1 4.7 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 0.3 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.1 0.5 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 0.2 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.0 0.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.1 GO:1900044 regulation of protein K63-linked ubiquitination(GO:1900044)
0.0 1.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.3 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.4 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.5 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 2.1 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.4 GO:0034605 cellular response to heat(GO:0034605)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.4 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.1 1.1 GO:0031091 platelet alpha granule(GO:0031091)
0.1 1.6 GO:0031143 pseudopodium(GO:0031143)
0.1 0.8 GO:0042629 mast cell granule(GO:0042629)
0.1 1.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 5.5 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.4 GO:0042382 paraspeckles(GO:0042382)
0.1 3.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 3.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.5 1.6 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.5 3.6 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.5 2.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.4 1.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 1.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 1.3 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.2 1.4 GO:1990239 steroid hormone binding(GO:1990239)
0.2 0.5 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.2 1.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.4 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.0 GO:0031419 cobalamin binding(GO:0031419)
0.1 4.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.6 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.5 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 2.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 1.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.2 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.8 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.4 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 5.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.3 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 4.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.1 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 0.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)