Motif ID: Nfatc3

Z-value: 1.462


Transcription factors associated with Nfatc3:

Gene SymbolEntrez IDGene Name
Nfatc3 ENSMUSG00000031902.9 Nfatc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3mm10_v2_chr8_+_106059562_106059623-0.301.6e-01Click!


Activity profile for motif Nfatc3.

activity profile for motif Nfatc3


Sorted Z-values histogram for motif Nfatc3

Sorted Z-values for motif Nfatc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 5.791 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_+_4611971 2.766 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr4_-_97584605 2.713 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 2.685 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr18_-_80713062 2.650 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr14_-_16575456 2.550 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr6_-_136875794 2.378 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr7_-_49636847 2.332 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr11_+_63133068 2.046 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr3_-_86548268 2.043 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr6_+_48841476 1.740 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr2_+_35282380 1.729 ENSMUST00000028239.6
 Gsn
gelsolin
chr6_+_48841633 1.720 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr16_-_22161450 1.674 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr6_+_47244359 1.650 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr3_-_37125943 1.628 ENSMUST00000029275.5
 Il2
interleukin 2
chr11_+_63132569 1.508 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr16_-_59555752 1.503 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr5_-_88527841 1.492 ENSMUST00000087033.3
 Igj
immunoglobulin joining chain
chr2_+_3114220 1.465 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 4.9 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.2 3.6 GO:0032060 bleb assembly(GO:0032060)
0.0 2.9 GO:0051028 mRNA transport(GO:0051028)
0.7 2.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 2.8 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.9 2.6 GO:0060854 patterning of lymph vessels(GO:0060854)
0.5 2.5 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 2.4 GO:0048754 branching morphogenesis of an epithelial tube(GO:0048754)
0.3 2.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.7 2.0 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.4 2.0 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 1.8 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 1.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.6 1.7 GO:1903903 striated muscle atrophy(GO:0014891) positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of establishment of T cell polarity(GO:1903903)
0.6 1.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 1.7 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.4 1.6 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.3 1.6 GO:0071205 clustering of voltage-gated potassium channels(GO:0045163) protein localization to juxtaparanode region of axon(GO:0071205)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0031012 extracellular matrix(GO:0031012)
0.1 3.6 GO:0043218 compact myelin(GO:0043218)
0.2 2.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 2.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 2.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.9 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 1.7 GO:0030478 actin cap(GO:0030478)
0.0 1.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 1.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.3 1.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 0.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.9 GO:0060077 inhibitory synapse(GO:0060077)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.1 GO:0008432 JUN kinase binding(GO:0008432)
0.9 2.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.3 2.6 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
0.1 2.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 2.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 2.0 GO:0001972 retinoic acid binding(GO:0001972)
0.5 1.9 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 1.8 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 1.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 1.7 GO:0017022 myosin binding(GO:0017022)
0.3 1.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.5 GO:0035326 enhancer binding(GO:0035326)
0.3 1.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 1.2 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)