Motif ID: Nfatc4

Z-value: 0.391


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.462.7e-02Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 3.294 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_+_83504032 1.120 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr18_-_62741387 0.819 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr3_-_37125943 0.804 ENSMUST00000029275.5
 Il2
interleukin 2
chr11_+_97415527 0.791 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr1_-_193370225 0.650 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370260 0.640 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr13_-_52981027 0.566 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr15_+_92051153 0.557 ENSMUST00000169825.1
 Cntn1
contactin 1
chr19_-_8839181 0.458 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr13_+_51846673 0.367 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr17_-_70849644 0.348 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr2_+_55435918 0.347 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr6_-_59024470 0.333 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr1_-_126830632 0.329 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr2_+_125136692 0.323 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr17_-_70851710 0.291 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr6_-_59024340 0.287 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr10_+_4611971 0.275 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr19_-_4943049 0.264 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr2_+_174330006 0.263 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
 Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus


chr14_+_70555900 0.239 ENSMUST00000163060.1
 Hr
hairless
chr2_+_3114220 0.215 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr9_-_35176039 0.196 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger

chr11_+_88718442 0.186 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr5_+_117363513 0.169 ENSMUST00000111959.1
 Wsb2
WD repeat and SOCS box-containing 2
chr7_-_79920599 0.163 ENSMUST00000075657.6
 Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr3_-_86548268 0.163 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr14_+_64950037 0.145 ENSMUST00000043914.5
 Ints9
integrator complex subunit 9
chr10_+_100488289 0.144 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr18_+_73863672 0.133 ENSMUST00000134847.1
 Mro
maestro
chr19_+_26623419 0.125 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chrX_+_48623737 0.123 ENSMUST00000114936.1
 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr10_+_21993890 0.116 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chrX_+_7638674 0.112 ENSMUST00000128890.1
 Syp
synaptophysin
chr3_-_106001474 0.101 ENSMUST00000066319.6
 Pifo
primary cilia formation
chr19_+_8839298 0.094 ENSMUST00000160556.1
 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr15_-_79062866 0.090 ENSMUST00000151889.1
ENSMUST00000040676.4
 Ankrd54

ankyrin repeat domain 54

chr14_-_25927672 0.082 ENSMUST00000185006.1
 Tmem254a
transmembrane protein 254a
chrX_+_159303266 0.080 ENSMUST00000112491.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr11_+_104608000 0.074 ENSMUST00000021028.4
 Itgb3
integrin beta 3
chr12_+_91400990 0.069 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr1_-_126830786 0.066 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr14_-_26067355 0.056 ENSMUST00000100819.5
 Tmem254c
transmembrane protein 254c
chr12_+_84451485 0.053 ENSMUST00000137170.1
 Lin52
lin-52 homolog (C. elegans)
chr7_-_84679346 0.050 ENSMUST00000069537.2
ENSMUST00000178385.1
 Zfand6

zinc finger, AN1-type domain 6

chr12_-_86079019 0.044 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr11_+_29692937 0.038 ENSMUST00000102843.3
ENSMUST00000102842.3
ENSMUST00000078830.4
ENSMUST00000170731.1
 Rtn4



reticulon 4



chr14_-_25927250 0.034 ENSMUST00000100811.5
 Tmem254a
transmembrane protein 254a
chr3_-_116662643 0.025 ENSMUST00000029570.5
 Hiat1
hippocampus abundant gene transcript 1
chr9_+_113812547 0.016 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr2_-_73453918 0.016 ENSMUST00000102679.1
 Wipf1
WAS/WASL interacting protein family, member 1
chr19_-_24477356 0.014 ENSMUST00000099556.1
 Fam122a
family with sequence similarity 122, member A
chr9_-_13446753 0.012 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr19_+_29101375 0.009 ENSMUST00000064393.5
 Rcl1
RNA terminal phosphate cyclase-like 1
chr16_-_59555752 0.009 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr18_-_15063560 0.007 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr11_-_35980473 0.002 ENSMUST00000018993.6
 Wwc1
WW, C2 and coiled-coil domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 1.1 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 0.8 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.2 0.8 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 0.3 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 0.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
0.1 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.4 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.0 0.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.0 0.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.3 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034679 integrin alpha9-beta1 complex(GO:0034679)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 1.1 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.5 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0070051 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132) fibrinogen binding(GO:0070051)
0.0 0.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)