Motif ID: Nfe2_Bach1_Mafk

Z-value: 0.778

Transcription factors associated with Nfe2_Bach1_Mafk:

Gene SymbolEntrez IDGene Name
Bach1 ENSMUSG00000025612.5 Bach1
Mafk ENSMUSG00000018143.4 Mafk
Nfe2 ENSMUSG00000058794.6 Nfe2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bach1mm10_v2_chr16_+_87698904_87698959-0.547.6e-03Click!
Mafkmm10_v2_chr5_+_139791513_1397915390.184.1e-01Click!
Nfe2mm10_v2_chr15_-_103251465_103251705-0.145.2e-01Click!


Activity profile for motif Nfe2_Bach1_Mafk.

activity profile for motif Nfe2_Bach1_Mafk


Sorted Z-values histogram for motif Nfe2_Bach1_Mafk

Sorted Z-values for motif Nfe2_Bach1_Mafk



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 2.787 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr6_+_5725639 2.256 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr9_-_86695897 2.235 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr7_-_126799134 1.279 ENSMUST00000087566.4
 Aldoa
aldolase A, fructose-bisphosphate
chr3_+_123267445 1.158 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr7_-_126799163 1.034 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr4_+_116685859 0.827 ENSMUST00000129315.1
ENSMUST00000106470.1
 Prdx1

peroxiredoxin 1

chr13_-_54611332 0.805 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611274 0.803 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr18_+_61045139 0.783 ENSMUST00000025522.4
ENSMUST00000115274.1
 Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr16_+_90220742 0.758 ENSMUST00000023707.9
 Sod1
superoxide dismutase 1, soluble
chr4_+_116685544 0.748 ENSMUST00000135573.1
ENSMUST00000151129.1
 Prdx1

peroxiredoxin 1

chr7_-_17056669 0.736 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chr16_+_17561885 0.679 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr6_-_72235559 0.675 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr6_+_5725812 0.640 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr18_+_73863672 0.634 ENSMUST00000134847.1
 Mro
maestro
chr15_+_84669565 0.633 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr19_-_8839181 0.590 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr1_+_125676969 0.586 ENSMUST00000027581.6
 Gpr39
G protein-coupled receptor 39

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 2.8 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.2 2.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 2.2 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 1.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 1.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.1 0.9 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.9 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.3 0.8 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 0.8 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 0.8 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.7 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.7 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.7 GO:0033198 response to ATP(GO:0033198)
0.2 0.6 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.2 0.6 GO:0043465 regulation of fermentation(GO:0043465) negative regulation of fermentation(GO:1901003)
0.2 0.6 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.6 GO:0035617 stress granule disassembly(GO:0035617)
0.1 0.6 GO:0005513 detection of calcium ion(GO:0005513)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 2.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.6 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.3 GO:0000502 proteasome complex(GO:0000502)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.0 GO:0031045 dense core granule(GO:0031045)
0.3 0.8 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.8 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.7 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.2 0.5 GO:0036501 UFD1-NPL4 complex(GO:0036501)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.4 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.4 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 GO:0045503 dynein light chain binding(GO:0045503)
0.1 2.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 2.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 2.2 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.1 1.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.9 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 0.8 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.8 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.7 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.7 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.2 0.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.5 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 0.5 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)