Motif ID: Nfix

Z-value: 1.373


Transcription factors associated with Nfix:

Gene SymbolEntrez IDGene Name
Nfix ENSMUSG00000001911.10 Nfix

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfixmm10_v2_chr8_-_84773381_847734270.951.0e-11Click!


Activity profile for motif Nfix.

activity profile for motif Nfix


Sorted Z-values histogram for motif Nfix

Sorted Z-values for motif Nfix



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfix

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 16.079 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr16_+_42907563 9.542 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr7_-_97417730 8.782 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr13_-_97747373 8.580 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_+_41532851 8.398 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr10_+_57784859 8.212 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr13_-_97747399 8.125 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr10_+_57784914 7.618 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr4_+_48045144 7.384 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_-_56969864 6.544 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr7_-_103827922 6.302 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr1_-_56969827 5.661 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr11_-_102897123 5.426 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr5_+_66745835 5.170 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr4_+_118961578 5.091 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr7_+_130936172 4.684 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr5_+_66968961 4.494 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr13_+_16014457 4.485 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr9_-_103222063 4.106 ENSMUST00000170904.1
 Trf
transferrin
chr9_+_89909775 4.101 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 16.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.9 15.8 GO:0060134 prepulse inhibition(GO:0060134)
0.4 12.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.8 12.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.4 8.6 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.3 8.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.3 8.1 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
2.5 7.4 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 6.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 5.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 5.2 GO:0045834 positive regulation of lipid metabolic process(GO:0045834)
0.8 4.7 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 4.6 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.9 4.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.5 4.3 GO:0097460 ferrous iron import into cell(GO:0097460)
0.0 4.2 GO:0007160 cell-matrix adhesion(GO:0007160)
0.7 4.1 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 3.8 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.2 3.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.2 3.1 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.8 GO:0005911 cell-cell junction(GO:0005911)
0.0 17.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 13.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 12.1 GO:0000118 histone deacetylase complex(GO:0000118)
2.2 8.6 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 6.5 GO:0009897 external side of plasma membrane(GO:0009897)
1.6 6.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 5.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 5.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.5 4.5 GO:0043512 inhibin A complex(GO:0043512)
0.5 4.1 GO:0097433 dense body(GO:0097433)
0.2 4.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 3.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.9 2.6 GO:0014802 terminal cisterna(GO:0014802)
0.1 2.6 GO:0071565 nBAF complex(GO:0071565)
0.4 2.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 1.9 GO:0005776 autophagosome(GO:0005776)
0.1 1.7 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.5 1.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.4 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 16.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.4 15.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 10.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 8.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 7.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 6.4 GO:0001223 transcription coactivator binding(GO:0001223)
1.6 6.3 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 6.2 GO:0003779 actin binding(GO:0003779)
1.9 5.6 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
1.7 5.1 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.2 4.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.6 4.1 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 4.1 GO:0070412 R-SMAD binding(GO:0070412)
0.1 4.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.7 4.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 3.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.4 3.7 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.1 3.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 3.2 GO:0008565 protein transporter activity(GO:0008565)
0.8 3.0 GO:0004064 arylesterase activity(GO:0004064)