Motif ID: Nfkb2

Z-value: 0.465


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_463048110.106.6e-01Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_74791516 1.846 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr13_-_111490111 0.921 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490028 0.857 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr8_+_108714644 0.764 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr2_-_37422869 0.694 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr11_+_77686155 0.682 ENSMUST00000100802.4
ENSMUST00000181023.1
 Nufip2

nuclear fragile X mental retardation protein interacting protein 2

chr11_-_84870712 0.658 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
 Ggnbp2



gametogenetin binding protein 2



chr11_-_84870646 0.645 ENSMUST00000018547.2
 Ggnbp2
gametogenetin binding protein 2
chr2_+_172550991 0.605 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chrX_+_163909132 0.533 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr11_-_84870812 0.526 ENSMUST00000168434.1
 Ggnbp2
gametogenetin binding protein 2
chr3_-_116424007 0.494 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A
chr10_+_59221945 0.493 ENSMUST00000182161.1
 Sowahc
sosondowah ankyrin repeat domain family member C
chr1_-_66817536 0.489 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr3_-_116423930 0.478 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr2_+_172550761 0.455 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr4_-_125127817 0.445 ENSMUST00000036188.7
 Zc3h12a
zinc finger CCCH type containing 12A
chr11_-_84870188 0.397 ENSMUST00000154915.2
 Ggnbp2
gametogenetin binding protein 2
chr1_-_5019342 0.391 ENSMUST00000002533.8
 Rgs20
regulator of G-protein signaling 20
chr1_+_135132693 0.343 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr11_+_70657687 0.319 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr7_+_29289300 0.308 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chrX_+_163908982 0.302 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr17_+_35379608 0.287 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr5_+_90759299 0.267 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr5_+_135887905 0.258 ENSMUST00000005077.6
 Hspb1
heat shock protein 1
chr17_+_35424842 0.252 ENSMUST00000174699.1
 H2-Q6
histocompatibility 2, Q region locus 6
chr11_+_101176041 0.251 ENSMUST00000103109.3
 Cntnap1
contactin associated protein-like 1
chr16_+_32914094 0.235 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
 Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr11_+_70657196 0.232 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr12_+_108792946 0.216 ENSMUST00000021692.7
 Yy1
YY1 transcription factor
chr11_-_68386821 0.207 ENSMUST00000021284.3
 Ntn1
netrin 1
chr10_-_89686250 0.203 ENSMUST00000092227.5
ENSMUST00000174252.1
 Scyl2

SCY1-like 2 (S. cerevisiae)

chr1_-_63114516 0.200 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr11_-_70656467 0.190 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr1_+_135133272 0.169 ENSMUST00000167080.1
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr5_+_135887988 0.161 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr19_+_6341121 0.138 ENSMUST00000025897.6
ENSMUST00000130382.1
 Map4k2

mitogen-activated protein kinase kinase kinase kinase 2

chr2_-_77816758 0.137 ENSMUST00000111831.1
 Zfp385b
zinc finger protein 385B
chr10_-_59221757 0.132 ENSMUST00000165971.1
 Sept10
septin 10
chr2_-_3419019 0.129 ENSMUST00000115084.1
ENSMUST00000115083.1
 Meig1

meiosis expressed gene 1

chr17_+_35866056 0.126 ENSMUST00000122899.1
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr5_+_90891234 0.125 ENSMUST00000031327.8
 Cxcl1
chemokine (C-X-C motif) ligand 1
chr1_+_167001417 0.112 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr2_+_102550012 0.111 ENSMUST00000028612.7
 Pamr1
peptidase domain containing associated with muscle regeneration 1
chr4_-_42168603 0.106 ENSMUST00000098121.3
 Gm13305
predicted gene 13305
chr17_+_35866606 0.083 ENSMUST00000113814.4
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr1_+_153740344 0.081 ENSMUST00000027748.7
 Rgs16
regulator of G-protein signaling 16
chr7_+_16309577 0.075 ENSMUST00000002152.6
 Bbc3
BCL2 binding component 3
chr19_+_7268296 0.073 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr1_-_63114255 0.073 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr19_+_45015198 0.069 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr14_-_30607808 0.058 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr7_+_3290553 0.048 ENSMUST00000096744.5
 Myadm
myeloid-associated differentiation marker
chr2_-_102451792 0.046 ENSMUST00000099678.3
 Fjx1
four jointed box 1 (Drosophila)
chr11_-_70015346 0.035 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr3_+_97658212 0.020 ENSMUST00000045743.6
 Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr14_-_118237016 0.015 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr2_-_3419066 0.014 ENSMUST00000115082.3
 Meig1
meiosis expressed gene 1
chr2_+_10153563 0.013 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5
chr5_-_114690906 0.008 ENSMUST00000112212.1
ENSMUST00000112214.1
 Gltp

glycolipid transfer protein

chr14_-_30626196 0.005 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 0.8 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 1.8 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.4 GO:0045472 response to ether(GO:0045472) negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of tumor necrosis factor secretion(GO:1904468)
0.1 1.0 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1 0.4 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943)
0.1 0.4 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.1 0.7 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.4 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.2 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.1 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.7 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 0.1 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.0 0.2 GO:0010225 response to UV-C(GO:0010225)
0.0 0.4 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.4 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.2 GO:0000400 four-way junction DNA binding(GO:0000400)