Motif ID: Nhlh1

Z-value: 1.287


Transcription factors associated with Nhlh1:

Gene SymbolEntrez IDGene Name
Nhlh1 ENSMUSG00000051251.3 Nhlh1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nhlh1mm10_v2_chr1_-_172057573_1720575980.321.4e-01Click!


Activity profile for motif Nhlh1.

activity profile for motif Nhlh1


Sorted Z-values histogram for motif Nhlh1

Sorted Z-values for motif Nhlh1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nhlh1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_111808938 3.673 ENSMUST00000109267.2
 Map3k1
mitogen-activated protein kinase kinase kinase 1
chr2_+_158375638 2.908 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr5_+_139543889 2.620 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr7_-_28302238 2.610 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr2_-_60963192 2.604 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr6_+_104492790 2.545 ENSMUST00000161446.1
ENSMUST00000161070.1
ENSMUST00000089215.5
 Cntn6


contactin 6


chr8_+_105518736 2.502 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr11_-_28583995 2.290 ENSMUST00000146385.2
 Ccdc85a
coiled-coil domain containing 85A
chr13_+_24638636 2.172 ENSMUST00000110384.2
ENSMUST00000058009.9
ENSMUST00000038477.6
 Fam65b


family with sequence similarity 65, member B


chr1_-_52500679 2.165 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr6_+_97807014 2.027 ENSMUST00000043637.7
 Mitf
microphthalmia-associated transcription factor
chr5_-_72587544 2.001 ENSMUST00000031124.4
 Gm5868
predicted gene 5868
chr8_+_31091593 1.976 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chrX_+_35888808 1.948 ENSMUST00000033419.6
 Dock11
dedicator of cytokinesis 11
chr2_-_172940299 1.944 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr6_+_7555053 1.862 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr8_-_105471481 1.848 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr7_+_62376979 1.777 ENSMUST00000080403.5
 Magel2
melanoma antigen, family L, 2
chr7_+_122289297 1.771 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr12_-_40037387 1.770 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 391 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.3 2.7 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.2 2.7 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 2.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 2.6 GO:0007386 compartment pattern specification(GO:0007386)
0.4 2.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.3 2.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 2.5 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.3 2.2 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.3 2.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.1 2.2 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 2.2 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 2.2 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 2.1 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.7 2.0 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 2.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.6 1.9 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.6 1.9 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.3 1.9 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.4 1.8 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0016605 PML body(GO:0016605)
0.5 4.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 4.0 GO:0031941 filamentous actin(GO:0031941)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.9 2.6 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 2.6 GO:0030904 retromer complex(GO:0030904)
0.1 2.5 GO:0032420 stereocilium(GO:0032420)
0.0 2.5 GO:0005871 kinesin complex(GO:0005871)
0.6 2.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 2.2 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.1 GO:0005902 microvillus(GO:0005902)
0.2 1.8 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)
0.3 1.7 GO:0045179 apical cortex(GO:0045179)
0.1 1.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 1.6 GO:0000776 kinetochore(GO:0000776)
0.2 1.5 GO:0070695 FHF complex(GO:0070695)
0.2 1.5 GO:0005883 neurofilament(GO:0005883)
0.2 1.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 226 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 GO:0005112 Notch binding(GO:0005112)
0.0 4.7 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 4.4 GO:0003779 actin binding(GO:0003779)
0.1 4.3 GO:0005109 frizzled binding(GO:0005109)
0.0 3.9 GO:0005525 GTP binding(GO:0005525)
0.2 3.7 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 3.7 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 3.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 3.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.7 2.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 2.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 2.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 2.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 2.2 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.1 2.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.7 2.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 2.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.9 GO:0071855 neuropeptide receptor binding(GO:0071855)