Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.689

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_55782500 12.769 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_23248264 5.703 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_60893430 4.682 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_+_140607334 2.119 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_+_52031549 1.930 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr4_-_141599835 1.838 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr13_-_102906046 1.769 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr12_-_40037387 1.746 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr7_-_143460989 1.697 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr13_-_102905740 1.586 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr14_+_46760526 1.511 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr5_+_9100681 1.469 ENSMUST00000115365.1
 Tmem243
transmembrane protein 243, mitochondrial
chr11_+_43682038 1.393 ENSMUST00000094294.4
 Pwwp2a
PWWP domain containing 2A
chr11_+_43681998 1.388 ENSMUST00000061070.5
 Pwwp2a
PWWP domain containing 2A
chr14_-_8666236 1.356 ENSMUST00000102996.3
 4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr19_+_5490475 1.174 ENSMUST00000116560.2
 Cfl1
cofilin 1, non-muscle
chr11_-_87108656 0.912 ENSMUST00000051395.8
 Prr11
proline rich 11
chr18_+_4993795 0.895 ENSMUST00000153016.1
 Svil
supervillin
chrX_+_106015699 0.881 ENSMUST00000033582.4
 Cox7b
cytochrome c oxidase subunit VIIb
chr11_+_87109221 0.876 ENSMUST00000020794.5
 Ska2
spindle and kinetochore associated complex subunit 2
chr14_-_5863663 0.827 ENSMUST00000178594.1
 Gm8237
predicted gene 8237
chr3_+_94372794 0.806 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr10_-_88146867 0.798 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr9_+_66126611 0.754 ENSMUST00000034945.5
 Fam96a
family with sequence similarity 96, member A
chr6_-_124779686 0.753 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr11_-_21371143 0.625 ENSMUST00000060895.5
 Ugp2
UDP-glucose pyrophosphorylase 2
chr14_-_52104015 0.617 ENSMUST00000111610.4
ENSMUST00000164655.1
 Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr4_-_140774196 0.609 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV
chr7_-_27195727 0.609 ENSMUST00000163311.2
ENSMUST00000126211.1
 Snrpa

small nuclear ribonucleoprotein polypeptide A

chr17_-_48432723 0.603 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr4_-_119294520 0.601 ENSMUST00000079644.6
 Ybx1
Y box protein 1
chr14_-_59365410 0.594 ENSMUST00000161031.1
ENSMUST00000160425.1
 Phf11d

PHD finger protein 11D

chr10_+_128337761 0.581 ENSMUST00000005826.7
 Cs
citrate synthase
chr7_+_128744870 0.571 ENSMUST00000042942.8
 Sec23ip
Sec23 interacting protein
chr5_+_138187485 0.565 ENSMUST00000110934.2
 Cnpy4
canopy 4 homolog (zebrafish)
chr9_-_100486788 0.544 ENSMUST00000098458.3
 Il20rb
interleukin 20 receptor beta
chr2_-_69712461 0.496 ENSMUST00000102706.3
ENSMUST00000073152.6
 Fastkd1

FAST kinase domains 1

chr1_+_174501796 0.495 ENSMUST00000030039.7
 Fmn2
formin 2
chr3_-_89101907 0.480 ENSMUST00000081848.8
 Fdps
farnesyl diphosphate synthetase
chr7_+_101896340 0.480 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
 Anapc15


anaphase prompoting complex C subunit 15


chr10_+_94575257 0.460 ENSMUST00000121471.1
 Tmcc3
transmembrane and coiled coil domains 3
chr12_+_52699297 0.453 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr5_+_138116903 0.446 ENSMUST00000062350.8
ENSMUST00000110961.2
ENSMUST00000080732.3
ENSMUST00000110960.2
ENSMUST00000142185.1
ENSMUST00000136425.1
ENSMUST00000110959.1
 Zscan21






zinc finger and SCAN domain containing 21






chr2_+_119047116 0.388 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr8_+_33599608 0.384 ENSMUST00000009774.9
 Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr12_+_84417196 0.383 ENSMUST00000183146.1
 Rnf113a2
ring finger protein 113A2
chr14_+_4198185 0.351 ENSMUST00000180184.1
 Gm2974
predicted gene 2974
chr11_-_99230998 0.338 ENSMUST00000103133.3
 Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr3_-_90389884 0.332 ENSMUST00000029541.5
 Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr10_+_88146992 0.330 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr4_-_14621669 0.326 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr14_-_6266620 0.321 ENSMUST00000096172.5
 Gm3411
predicted gene 3411
chr10_+_88147061 0.314 ENSMUST00000169309.1
 Nup37
nucleoporin 37
chr17_-_63863791 0.303 ENSMUST00000050753.3
 A930002H24Rik
RIKEN cDNA A930002H24 gene
chr11_-_43747963 0.293 ENSMUST00000048578.2
ENSMUST00000109278.1
 Ttc1

tetratricopeptide repeat domain 1

chr7_+_101896817 0.289 ENSMUST00000143835.1
 Anapc15
anaphase prompoting complex C subunit 15
chr15_+_81663889 0.269 ENSMUST00000023029.8
ENSMUST00000174229.1
ENSMUST00000172748.1
 L3mbtl2


l(3)mbt-like 2 (Drosophila)


chr2_+_119047129 0.253 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr2_-_37703845 0.252 ENSMUST00000155237.1
 Strbp
spermatid perinuclear RNA binding protein
chr9_-_107872403 0.235 ENSMUST00000183035.1
 Rbm6
RNA binding motif protein 6
chr17_-_57031468 0.206 ENSMUST00000007814.8
 Khsrp
KH-type splicing regulatory protein
chr7_-_100964371 0.180 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr4_-_132075250 0.179 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr1_-_172027269 0.177 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr11_+_121237216 0.173 ENSMUST00000103015.3
 Narf
nuclear prelamin A recognition factor
chr2_-_132247747 0.168 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
 Tmem230


transmembrane protein 230


chr9_-_20959785 0.167 ENSMUST00000177754.1
 Dnmt1
DNA methyltransferase (cytosine-5) 1
chr2_-_165388245 0.165 ENSMUST00000103084.3
 Zfp334
zinc finger protein 334
chr9_-_55919605 0.138 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr3_-_34351685 0.126 ENSMUST00000174114.1
 Gm20514
predicted gene 20514
chr16_-_16359016 0.114 ENSMUST00000023477.7
ENSMUST00000096229.3
ENSMUST00000115749.1
 Dnm1l


dynamin 1-like


chr6_+_37870786 0.110 ENSMUST00000120428.1
ENSMUST00000031859.7
 Trim24

tripartite motif-containing 24

chr7_+_51880312 0.095 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr2_+_151494182 0.089 ENSMUST00000089140.6
 Nsfl1c
NSFL1 (p97) cofactor (p47)
chr19_+_29367447 0.081 ENSMUST00000016640.7
 Cd274
CD274 antigen
chr5_-_137072254 0.065 ENSMUST00000077523.3
ENSMUST00000041388.4
 Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr5_-_118244861 0.063 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr7_-_30552255 0.052 ENSMUST00000108165.1
ENSMUST00000153594.1
 BC053749

cDNA sequence BC053749

chrX_-_160138375 0.049 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr7_+_29983948 0.040 ENSMUST00000148442.1
 Zfp568
zinc finger protein 568
chr8_+_83972951 0.029 ENSMUST00000005606.6
 Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr9_-_44113470 0.028 ENSMUST00000056328.5
 Rnf26
ring finger protein 26
chr19_+_41933464 0.025 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr5_+_115605642 0.023 ENSMUST00000094427.3
 Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr5_-_34660068 0.021 ENSMUST00000041364.9
 Nop14
NOP14 nucleolar protein
chr14_+_118854695 0.018 ENSMUST00000100314.3
 Cldn10
claudin 10
chr12_+_4769278 0.006 ENSMUST00000020967.4
 Pfn4
profilin family, member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 1.9 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.4 2.1 GO:0007386 compartment pattern specification(GO:0007386)
0.3 4.7 GO:0007530 sex determination(GO:0007530)
0.2 0.6 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.2 0.5 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.2 1.2 GO:0001842 neural fold formation(GO:0001842)
0.2 0.5 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)
0.2 0.6 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 0.8 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 1.8 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.5 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 1.7 GO:0060065 uterus development(GO:0060065)
0.1 0.6 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 0.5 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.1 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.8 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.2 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.6 GO:0001675 acrosome assembly(GO:0001675)
0.1 0.2 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 1.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.6 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.4 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.8 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 12.0 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.1 GO:0061043 regulation of vascular wound healing(GO:0061043)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0 0.0 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 0.1 GO:0090148 membrane fission(GO:0090148)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.2 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.9 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.1 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.4 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.9 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 2.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.6 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0045120 telomerase holoenzyme complex(GO:0005697) pronucleus(GO:0045120)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.4 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.2 0.8 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 4.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.5 GO:0004337 geranyltranstransferase activity(GO:0004337)
0.1 1.8 GO:0031005 filamin binding(GO:0031005)
0.1 0.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.6 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.1 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.3 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0 4.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 2.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)