Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.689

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 12.769 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_23248264 5.703 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_60893430 4.682 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_+_140607334 2.119 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_+_52031549 1.930 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr4_-_141599835 1.838 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr13_-_102906046 1.769 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr12_-_40037387 1.746 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr7_-_143460989 1.697 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr13_-_102905740 1.586 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr14_+_46760526 1.511 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr5_+_9100681 1.469 ENSMUST00000115365.1
 Tmem243
transmembrane protein 243, mitochondrial
chr11_+_43682038 1.393 ENSMUST00000094294.4
 Pwwp2a
PWWP domain containing 2A
chr11_+_43681998 1.388 ENSMUST00000061070.5
 Pwwp2a
PWWP domain containing 2A
chr14_-_8666236 1.356 ENSMUST00000102996.3
 4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr19_+_5490475 1.174 ENSMUST00000116560.2
 Cfl1
cofilin 1, non-muscle
chr11_-_87108656 0.912 ENSMUST00000051395.8
 Prr11
proline rich 11
chr18_+_4993795 0.895 ENSMUST00000153016.1
 Svil
supervillin
chrX_+_106015699 0.881 ENSMUST00000033582.4
 Cox7b
cytochrome c oxidase subunit VIIb
chr11_+_87109221 0.876 ENSMUST00000020794.5
 Ska2
spindle and kinetochore associated complex subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.0 GO:0043010 camera-type eye development(GO:0043010)
1.0 5.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 4.7 GO:0007530 sex determination(GO:0007530)
0.4 2.1 GO:0007386 compartment pattern specification(GO:0007386)
0.6 1.9 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 1.8 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 1.7 GO:0060065 uterus development(GO:0060065)
0.0 1.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 1.2 GO:0001842 neural fold formation(GO:0001842)
0.0 0.9 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 0.8 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 0.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.8 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.8 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 0.6 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.2 0.6 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 0.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.6 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 0.6 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.6 GO:0080111 DNA demethylation(GO:0080111)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 0.9 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.6 GO:0045120 telomerase holoenzyme complex(GO:0005697) pronucleus(GO:0045120)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 4.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.5 GO:0000287 magnesium ion binding(GO:0000287)
0.7 2.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 1.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.8 GO:0031005 filamin binding(GO:0031005)
0.1 1.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.8 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.6 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.0 0.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.5 GO:0004337 geranyltranstransferase activity(GO:0004337)
0.1 0.5 GO:0043495 protein anchor(GO:0043495)