Motif ID: Nkx2-2
Z-value: 1.591
Transcription factors associated with Nkx2-2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-2 | ENSMUSG00000027434.10 | Nkx2-2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-2 | mm10_v2_chr2_-_147186389_147186413 | -0.09 | 6.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | GO:0051542 | elastin biosynthetic process(GO:0051542) |
| 0.8 | 3.9 | GO:0031033 | myosin filament organization(GO:0031033) |
| 0.7 | 2.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.6 | 1.7 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.5 | 2.7 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
| 0.5 | 1.9 | GO:0034454 | microtubule anchoring at centrosome(GO:0034454) |
| 0.5 | 1.8 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.5 | 3.2 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.4 | 2.5 | GO:0006046 | N-acetylglucosamine catabolic process(GO:0006046) |
| 0.4 | 1.6 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.4 | 1.5 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.3 | 3.4 | GO:1902170 | cellular response to reactive nitrogen species(GO:1902170) |
| 0.3 | 1.5 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.3 | 0.9 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.3 | 1.4 | GO:0030242 | pexophagy(GO:0030242) |
| 0.3 | 0.8 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
| 0.2 | 0.7 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.2 | 1.1 | GO:0032911 | nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.2 | 0.6 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.2 | 0.8 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.2 | 3.8 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.2 | 0.6 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
| 0.2 | 0.5 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.2 | 2.9 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.2 | 2.4 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.1 | 0.6 | GO:1903463 | mitotic cell cycle phase(GO:0098763) regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.1 | 1.3 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.1 | 0.9 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.1 | 0.6 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 0.1 | 0.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.1 | 0.5 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.1 | 0.6 | GO:0009052 | pentose-phosphate shunt, non-oxidative branch(GO:0009052) |
| 0.1 | 2.5 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.1 | 0.8 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.1 | 0.2 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.1 | 1.2 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.9 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.1 | 2.0 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.1 | 2.3 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.1 | 0.7 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
| 0.1 | 2.5 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 1.8 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.1 | 1.9 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.1 | 1.7 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
| 0.0 | 0.3 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.0 | 0.5 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.0 | 0.6 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.0 | 0.1 | GO:0046078 | deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078) |
| 0.0 | 3.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.2 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.0 | 0.5 | GO:0009072 | aromatic amino acid family metabolic process(GO:0009072) |
| 0.0 | 1.6 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.7 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 1.1 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.3 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.1 | GO:0051182 | coenzyme transport(GO:0051182) |
| 0.0 | 4.7 | GO:0006275 | regulation of DNA replication(GO:0006275) |
| 0.0 | 0.5 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
| 0.0 | 3.6 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 0.5 | GO:0072337 | modified amino acid transport(GO:0072337) |
| 0.0 | 0.3 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.4 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.0 | 0.6 | GO:0048662 | negative regulation of smooth muscle cell proliferation(GO:0048662) |
| 0.0 | 0.2 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.0 | 0.1 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 0.7 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.3 | 1.4 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.3 | 1.7 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.2 | 1.5 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 6.1 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.2 | 1.9 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 2.7 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.2 | 3.9 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.2 | 2.6 | GO:0043205 | fibril(GO:0043205) |
| 0.1 | 1.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 1.7 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 1.6 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 1.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.5 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.1 | 1.9 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 0.2 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522) |
| 0.1 | 0.4 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 6.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 0.8 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 2.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.5 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.3 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.9 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 2.0 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 1.9 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 2.9 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.3 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 1.7 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.6 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.8 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.3 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.1 | GO:0030175 | filopodium(GO:0030175) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | GO:0004008 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 0.8 | 4.2 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.5 | 2.5 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.4 | 3.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.4 | 2.4 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 0.3 | 2.7 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.2 | 5.7 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.2 | 1.9 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.2 | 1.0 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 1.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 3.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 0.5 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.1 | 1.1 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 0.5 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.1 | 3.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 1.7 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 1.6 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 0.6 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 0.3 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.1 | 0.5 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 0.8 | GO:0034951 | pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011) |
| 0.1 | 1.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 0.4 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.1 | 0.5 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.0 | 1.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 2.9 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 2.6 | GO:0044824 | integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824) |
| 0.0 | 2.5 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.7 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 0.2 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 1.7 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 1.4 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 1.5 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.6 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
| 0.0 | 1.1 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.3 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.6 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.2 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.5 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.5 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.1 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 1.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.6 | GO:0052771 | coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771) |
| 0.0 | 0.6 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.1 | GO:0008235 | metalloexopeptidase activity(GO:0008235) |
| 0.0 | 0.5 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 5.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.5 | GO:0004896 | cytokine receptor activity(GO:0004896) |
