Motif ID: Nkx2-2

Z-value: 1.591


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_147186413-0.096.8e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 198 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_19418930 4.499 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 4.317 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr3_+_5218516 4.111 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr9_+_3034599 3.994 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr4_+_46039202 3.930 ENSMUST00000156200.1
 Tmod1
tropomodulin 1
chr9_+_3005125 3.805 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr3_-_49757257 3.800 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr9_+_3015654 3.795 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3025417 3.779 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3017408 3.770 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr2_+_62664279 3.615 ENSMUST00000028257.2
 Gca
grancalcin
chr3_+_118433797 3.499 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr1_-_166002613 3.168 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr1_-_135688094 3.160 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr13_-_41487306 3.150 ENSMUST00000021794.6
 Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr10_+_106470281 3.144 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr2_-_140170528 3.090 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr9_-_96719549 2.935 ENSMUST00000128269.1
 Zbtb38
zinc finger and BTB domain containing 38
chr3_-_84304762 2.861 ENSMUST00000107692.1
 Trim2
tripartite motif-containing 2
chr9_-_96719404 2.756 ENSMUST00000140121.1
 Zbtb38
zinc finger and BTB domain containing 38

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 5.0 GO:0051542 elastin biosynthetic process(GO:0051542)
0.0 4.7 GO:0006275 regulation of DNA replication(GO:0006275)
0.8 3.9 GO:0031033 myosin filament organization(GO:0031033)
0.2 3.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 3.6 GO:0031032 actomyosin structure organization(GO:0031032)
0.3 3.4 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.5 3.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 3.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 2.9 GO:0070986 left/right axis specification(GO:0070986)
0.5 2.7 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.7 2.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.4 2.5 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.1 2.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 2.5 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 2.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 2.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 2.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.5 1.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 1.9 GO:0006491 N-glycan processing(GO:0006491)
0.5 1.8 GO:0035063 nuclear speck organization(GO:0035063)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 GO:0072562 blood microparticle(GO:0072562)
0.2 6.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 3.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.9 GO:0005882 intermediate filament(GO:0005882)
0.0 2.9 GO:0000922 spindle pole(GO:0000922)
0.2 2.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 2.6 GO:0043205 fibril(GO:0043205)
0.0 2.0 GO:0031985 Golgi cisterna(GO:0031985)
0.2 1.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.9 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.6 1.7 GO:0005899 insulin receptor complex(GO:0005899)
0.3 1.7 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.7 GO:0016460 myosin II complex(GO:0016460)
0.0 1.7 GO:0005814 centriole(GO:0005814)
0.1 1.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.6 GO:0035253 ciliary rootlet(GO:0035253)
0.2 1.5 GO:0001940 male pronucleus(GO:0001940)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.3 1.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 5.6 GO:0005509 calcium ion binding(GO:0005509)
1.7 5.0 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.8 4.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.4 3.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 3.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 3.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 2.9 GO:0017022 myosin binding(GO:0017022)
0.3 2.7 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.0 2.6 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.5 2.5 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 2.5 GO:0000049 tRNA binding(GO:0000049)
0.4 2.4 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.2 1.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 1.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.7 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.5 GO:0019894 kinesin binding(GO:0019894)
0.1 1.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)