Motif ID: Nkx2-3

Z-value: 0.849


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_436123250.048.6e-01Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_38783503 13.459 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_38783455 10.812 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr6_-_23248264 8.517 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_+_139543889 4.773 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_-_6980376 4.612 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr12_+_38780817 4.157 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr12_+_38780284 4.044 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr1_+_6730051 3.922 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr1_+_6734827 3.825 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr2_+_136057927 3.486 ENSMUST00000057503.6
 Lamp5
lysosomal-associated membrane protein family, member 5
chr6_+_34354119 3.120 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr3_+_55782500 2.926 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr14_+_75455957 2.819 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr13_+_83504032 2.565 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr3_+_102010138 2.553 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr18_+_50030977 2.526 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr13_-_114458720 2.515 ENSMUST00000022287.5
 Fst
follistatin
chr3_+_134236483 2.474 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr2_-_166155272 2.466 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr2_-_166155624 2.430 ENSMUST00000109249.2
 Sulf2
sulfatase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 36.3 GO:0007638 mechanosensory behavior(GO:0007638)
1.6 9.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.2 4.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.6 3.6 GO:0060539 diaphragm development(GO:0060539)
0.0 3.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
1.0 3.1 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.6 2.8 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.4 2.7 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.9 2.6 GO:2001016 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.1 2.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 2.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 2.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 2.2 GO:0032611 interleukin-1 beta production(GO:0032611)
0.2 2.1 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 2.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.2 2.0 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 2.0 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.2 1.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 1.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.9 GO:0021954 central nervous system neuron development(GO:0021954)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 GO:0043034 costamere(GO:0043034)
0.6 3.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 2.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 2.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 2.6 GO:0016607 nuclear speck(GO:0016607)
0.2 2.1 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.7 GO:0005922 connexon complex(GO:0005922)
0.1 1.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 1.3 GO:0005818 aster(GO:0005818)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.2 1.1 GO:0001940 male pronucleus(GO:0001940)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.0 GO:0033269 internode region of axon(GO:0033269)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.2 0.8 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.8 GO:0098536 deuterosome(GO:0098536)
0.0 0.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 42.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.0 4.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 3.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 3.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.2 GO:0051015 actin filament binding(GO:0051015)
0.5 3.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.2 3.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 3.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 2.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 2.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 2.5 GO:0048185 activin binding(GO:0048185)
0.1 2.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.7 2.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 2.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 2.0 GO:0015197 peptide transporter activity(GO:0015197)
0.4 1.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 1.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.5 GO:0070491 repressing transcription factor binding(GO:0070491)