Motif ID: Nkx2-4

Z-value: 0.491


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_147085483-0.213.3e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Showing 1 to 20 of 90 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_34812677 1.676 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr8_+_45628176 1.147 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr13_-_66852017 1.139 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr8_+_45627946 1.115 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr5_+_32136458 0.976 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr2_+_169632996 0.749 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr7_-_115824699 0.718 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chrX_-_143933089 0.663 ENSMUST00000087313.3
 Dcx
doublecortin
chr3_+_76593550 0.621 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr11_+_87592897 0.597 ENSMUST00000119628.1
 Mtmr4
myotubularin related protein 4
chr1_+_178798438 0.586 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr3_+_88629499 0.555 ENSMUST00000175745.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr2_+_169633517 0.549 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr2_-_93046053 0.540 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr11_+_70026815 0.536 ENSMUST00000135916.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr2_-_27507656 0.518 ENSMUST00000154316.1
 Brd3
bromodomain containing 3
chr12_+_38780817 0.504 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr14_+_48446128 0.485 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr10_+_88091070 0.458 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chrX_-_158043266 0.438 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.7 GO:0016486 peptide hormone processing(GO:0016486)
0.1 1.0 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.6 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.6 GO:0071225 cellular response to muramyl dipeptide(GO:0071225)
0.2 0.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.0 0.5 GO:2000821 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of grooming behavior(GO:2000821)
0.0 0.5 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1 0.4 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.4 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.0 0.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 0.2 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 0.2 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 0.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0044299 C-fiber(GO:0044299)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.4 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.2 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)