Motif ID: Nkx2-4

Z-value: 0.491


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_147085483-0.213.3e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_34812677 1.676 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr8_+_45628176 1.147 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr13_-_66852017 1.139 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr8_+_45627946 1.115 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr5_+_32136458 0.976 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr2_+_169632996 0.749 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr7_-_115824699 0.718 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chrX_-_143933089 0.663 ENSMUST00000087313.3
 Dcx
doublecortin
chr3_+_76593550 0.621 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr11_+_87592897 0.597 ENSMUST00000119628.1
 Mtmr4
myotubularin related protein 4
chr1_+_178798438 0.586 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr3_+_88629499 0.555 ENSMUST00000175745.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr2_+_169633517 0.549 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr2_-_93046053 0.540 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr11_+_70026815 0.536 ENSMUST00000135916.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr2_-_27507656 0.518 ENSMUST00000154316.1
 Brd3
bromodomain containing 3
chr12_+_38780817 0.504 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr14_+_48446128 0.485 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr10_+_88091070 0.458 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chrX_-_158043266 0.438 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr18_+_36952621 0.422 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr3_-_110250963 0.418 ENSMUST00000106567.1
 Prmt6
protein arginine N-methyltransferase 6
chr13_+_108860072 0.397 ENSMUST00000177907.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr8_+_45627709 0.359 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr15_-_26895049 0.355 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr1_+_97024681 0.347 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr13_+_108316395 0.339 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr6_+_30568367 0.327 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr1_+_85650008 0.327 ENSMUST00000054279.8
ENSMUST00000147552.1
ENSMUST00000153574.1
ENSMUST00000150967.1
 Sp100



nuclear antigen Sp100



chr11_+_101733011 0.318 ENSMUST00000129741.1
 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr14_-_47418407 0.309 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr17_-_25844417 0.295 ENSMUST00000176591.1
 Rhot2
ras homolog gene family, member T2
chr11_+_98863610 0.287 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr2_+_157456917 0.286 ENSMUST00000109529.1
 Src
Rous sarcoma oncogene
chr15_+_99055164 0.280 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr14_+_26514554 0.279 ENSMUST00000104927.1
 Gm2178
predicted gene 2178
chr12_+_38781093 0.278 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr11_+_101732950 0.270 ENSMUST00000039152.7
 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr2_+_61804453 0.269 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr11_-_103697661 0.247 ENSMUST00000107013.2
 Gosr2
golgi SNAP receptor complex member 2
chr9_-_71896047 0.242 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr8_-_31739763 0.237 ENSMUST00000178878.1
 Gm5117
predicted gene 5117
chr6_-_91807318 0.224 ENSMUST00000159684.1
 Grip2
glutamate receptor interacting protein 2
chr3_-_108200807 0.222 ENSMUST00000106655.1
ENSMUST00000065664.6
 Cyb561d1

cytochrome b-561 domain containing 1

chr1_-_37536232 0.221 ENSMUST00000042161.8
 Mgat4a
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr7_-_132813095 0.219 ENSMUST00000106165.1
 Fam53b
family with sequence similarity 53, member B
chr12_-_91746020 0.218 ENSMUST00000166967.1
 Ston2
stonin 2
chr17_-_25844514 0.200 ENSMUST00000176709.1
 Rhot2
ras homolog gene family, member T2
chr6_+_96113146 0.187 ENSMUST00000122120.1
 Fam19a1
family with sequence similarity 19, member A1
chr4_+_62525369 0.185 ENSMUST00000062145.1
 4933430I17Rik
RIKEN cDNA 4933430I17 gene
chr12_-_105685235 0.183 ENSMUST00000041055.7
 Atg2b
autophagy related 2B
chr1_+_34439851 0.183 ENSMUST00000027303.7
 Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chrX_-_143933204 0.175 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr10_+_4611971 0.175 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr11_+_110968016 0.171 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr8_+_31091593 0.169 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr19_-_5457397 0.168 ENSMUST00000179549.1
 Ccdc85b
coiled-coil domain containing 85B
chr2_-_85035487 0.155 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr17_+_84956718 0.143 ENSMUST00000112305.3
 Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
chr6_-_91807424 0.131 ENSMUST00000162300.1
 Grip2
glutamate receptor interacting protein 2
chr2_+_25180737 0.122 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr2_-_157566319 0.111 ENSMUST00000109528.2
ENSMUST00000088494.2
 Blcap

bladder cancer associated protein homolog (human)

chr2_-_34755229 0.108 ENSMUST00000102800.1
 Gapvd1
GTPase activating protein and VPS9 domains 1
chr2_+_30061754 0.107 ENSMUST00000149578.1
ENSMUST00000102866.3
 Set

SET nuclear oncogene

chr15_+_99670574 0.106 ENSMUST00000023758.7
 Asic1
acid-sensing (proton-gated) ion channel 1
chr19_-_45742873 0.084 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr2_-_85196697 0.084 ENSMUST00000099930.2
ENSMUST00000111601.1
 Lrrc55

leucine rich repeat containing 55

chr5_+_24685815 0.081 ENSMUST00000068825.6
 Nub1
negative regulator of ubiquitin-like proteins 1
chr5_-_137533170 0.079 ENSMUST00000168746.1
ENSMUST00000170293.1
 Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr13_+_65512678 0.078 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr11_+_110968056 0.076 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr6_+_31574967 0.074 ENSMUST00000150540.1
 Gm6117
predicted gene 6117
chrX_-_140956675 0.071 ENSMUST00000033805.8
ENSMUST00000112978.1
 Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr10_+_20347788 0.069 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr5_-_137533297 0.067 ENSMUST00000111020.1
ENSMUST00000111023.1
 Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr1_+_85650044 0.062 ENSMUST00000066427.4
 Sp100
nuclear antigen Sp100
chr6_-_29165003 0.054 ENSMUST00000007993.9
 Rbm28
RNA binding motif protein 28
chr1_-_34439672 0.053 ENSMUST00000042493.8
 Ccdc115
coiled-coil domain containing 115
chr6_+_123229843 0.051 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chr4_-_108848619 0.048 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr5_-_137533212 0.028 ENSMUST00000111038.1
ENSMUST00000143495.1
 Epo
Gnb2
erythropoietin
guanine nucleotide binding protein (G protein), beta 2
chr12_+_69963452 0.023 ENSMUST00000110560.1
 Gm3086
predicted gene 3086
chr14_-_55671873 0.022 ENSMUST00000163750.1
ENSMUST00000010520.8
 Nedd8

neural precursor cell expressed, developmentally down-regulated gene 8

chr4_-_40279389 0.021 ENSMUST00000108108.2
ENSMUST00000095128.3
 Ndufb6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6

chrX_+_56447965 0.014 ENSMUST00000079663.6
 Gm2174
predicted gene 2174
chr6_-_97060407 0.013 ENSMUST00000089295.4
 Fam19a4
family with sequence similarity 19, member A4
chr9_-_57440084 0.012 ENSMUST00000085709.4
 Ppcdc
phosphopantothenoylcysteine decarboxylase
chr5_+_34999111 0.010 ENSMUST00000114283.1
 Rgs12
regulator of G-protein signaling 12
chr14_+_55672235 0.002 ENSMUST00000002397.5
 Gmpr2
guanosine monophosphate reductase 2
chr8_-_40308331 0.001 ENSMUST00000118639.1
 Fgf20
fibroblast growth factor 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 0.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.4 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 1.7 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.2 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 2.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.2 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 0.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 1.0 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.6 GO:0071225 cellular response to muramyl dipeptide(GO:0071225)
0.0 0.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.4 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.5 GO:2000821 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of grooming behavior(GO:2000821)
0.0 0.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:0060129 otic vesicle formation(GO:0030916) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0018377 N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.5 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0044299 C-fiber(GO:0044299)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.4 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 0.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 1.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0071855 neuropeptide receptor binding(GO:0071855)