Motif ID: Nkx2-5

Z-value: 0.470


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_80000292 2.627 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr15_-_88978958 2.548 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr3_+_52268337 1.667 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr1_+_172341197 1.514 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr12_+_37880700 1.182 ENSMUST00000040500.7
 Dgkb
diacylglycerol kinase, beta
chr9_-_53536608 1.094 ENSMUST00000150244.1
 Atm
ataxia telangiectasia mutated homolog (human)
chr18_-_79109391 1.067 ENSMUST00000025430.8
ENSMUST00000161465.2
 Setbp1

SET binding protein 1

chr17_+_88440711 1.024 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr15_-_10470490 1.022 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr5_-_124327812 0.911 ENSMUST00000184951.1
 Mphosph9
M-phase phosphoprotein 9
chr4_-_87806276 0.904 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr6_-_101377342 0.870 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr4_-_87806296 0.857 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr19_+_26753588 0.856 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_124327883 0.720 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr1_-_66817536 0.707 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr2_+_174076296 0.638 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
 Stx16


syntaxin 16


chr2_-_5942740 0.622 ENSMUST00000026924.5
ENSMUST00000095147.2
ENSMUST00000169865.1
 Dhtkd1


dehydrogenase E1 and transketolase domain containing 1


chr9_+_57940104 0.614 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr7_-_126897424 0.526 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr2_-_173276144 0.516 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr15_-_54919961 0.515 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr6_+_30541582 0.497 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr3_-_89160155 0.472 ENSMUST00000029686.3
 Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr16_+_44173271 0.470 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chrX_-_75416533 0.463 ENSMUST00000033542.4
 Mtcp1
mature T cell proliferation 1
chr1_-_163725123 0.460 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr17_-_29716969 0.452 ENSMUST00000129091.1
ENSMUST00000128751.1
 Ccdc167

coiled-coil domain containing 167

chr6_-_115853346 0.419 ENSMUST00000032469.6
 Mbd4
methyl-CpG binding domain protein 4
chr5_+_138085083 0.419 ENSMUST00000019660.4
ENSMUST00000066617.5
ENSMUST00000110963.1
 Zkscan1


zinc finger with KRAB and SCAN domains 1


chr12_+_4082596 0.370 ENSMUST00000049584.5
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr5_-_8997324 0.366 ENSMUST00000003720.4
 Crot
carnitine O-octanoyltransferase
chr18_+_49832622 0.359 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr8_-_46294592 0.354 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr11_+_4620067 0.353 ENSMUST00000109941.1
 Gm11032
predicted gene 11032
chr15_-_54920115 0.339 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr1_-_86359455 0.338 ENSMUST00000027438.6
 Ncl
nucleolin
chr7_+_29071597 0.331 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr4_+_42714926 0.329 ENSMUST00000178454.1
 Gm21955
predicted gene, 21955
chr4_+_137594140 0.326 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
 Usp48



ubiquitin specific peptidase 48



chr4_-_126968124 0.317 ENSMUST00000106108.2
 Zmym4
zinc finger, MYM-type 4
chr2_+_80315461 0.304 ENSMUST00000028392.7
 Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr18_-_31949571 0.301 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr17_+_35379608 0.295 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr8_+_124793061 0.294 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr1_+_128103297 0.292 ENSMUST00000036288.4
 R3hdm1
R3H domain containing 1
chr14_+_21500879 0.260 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chr12_+_4082574 0.255 ENSMUST00000020986.7
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr16_-_44139630 0.245 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr6_-_83572429 0.241 ENSMUST00000068054.7
 Stambp
STAM binding protein
chr15_-_82224330 0.224 ENSMUST00000089161.2
ENSMUST00000109535.2
 Tnfrsf13c

tumor necrosis factor receptor superfamily, member 13c

chr16_+_44139821 0.205 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
 Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr19_+_16956110 0.200 ENSMUST00000087689.4
 Prune2
prune homolog 2 (Drosophila)
chr11_-_80080928 0.200 ENSMUST00000103233.3
ENSMUST00000061283.8
 Crlf3

cytokine receptor-like factor 3

chrX_-_75416562 0.198 ENSMUST00000114081.1
ENSMUST00000033543.7
ENSMUST00000149863.2
 Mtcp1
Mtcp1

mature T cell proliferation 1
mature T cell proliferation 1

chr16_+_44943737 0.196 ENSMUST00000114622.3
ENSMUST00000166731.1
 Cd200r3

CD200 receptor 3

chr19_-_57360668 0.195 ENSMUST00000181921.1
 B230217O12Rik
RIKEN cDNA B230217O12 gene
chr7_+_18991245 0.194 ENSMUST00000130268.1
ENSMUST00000059331.8
ENSMUST00000131087.1
 Mypop


Myb-related transcription factor, partner of profilin


chr11_-_96916366 0.192 ENSMUST00000144731.1
ENSMUST00000127048.1
 Cdk5rap3

CDK5 regulatory subunit associated protein 3

chr2_+_127270208 0.191 ENSMUST00000110375.2
 Stard7
START domain containing 7
chr15_-_99457712 0.191 ENSMUST00000161948.1
 Nckap5l
NCK-associated protein 5-like
chr14_+_70530819 0.190 ENSMUST00000047331.6
 Lgi3
leucine-rich repeat LGI family, member 3
chr2_+_120609383 0.185 ENSMUST00000124187.1
 Haus2
HAUS augmin-like complex, subunit 2
chr9_+_44773027 0.180 ENSMUST00000125877.1
 Ift46
intraflagellar transport 46
chr19_+_8819401 0.174 ENSMUST00000096753.3
 Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr5_+_124328083 0.174 ENSMUST00000111477.1
ENSMUST00000077376.2
 2810006K23Rik

RIKEN cDNA 2810006K23 gene

chr11_-_96916407 0.171 ENSMUST00000130774.1
 Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr2_+_131234043 0.159 ENSMUST00000041362.5
ENSMUST00000110199.2
 Mavs

mitochondrial antiviral signaling protein

chrX_-_111463103 0.156 ENSMUST00000137712.2
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr11_-_3976778 0.147 ENSMUST00000042344.1
 4930556J24Rik
RIKEN cDNA 4930556J24 gene
chr13_+_30136498 0.140 ENSMUST00000047311.8
 Mboat1
membrane bound O-acyltransferase domain containing 1
chr9_+_44772951 0.135 ENSMUST00000128150.1
 Ift46
intraflagellar transport 46
chr4_-_140323302 0.133 ENSMUST00000063789.2
 Gm9867
predicted gene 9867
chr4_-_4138432 0.132 ENSMUST00000070375.7
 Penk
preproenkephalin
chr6_+_42286709 0.119 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chr9_+_44772909 0.111 ENSMUST00000002099.3
 Ift46
intraflagellar transport 46
chr15_-_99457742 0.110 ENSMUST00000023747.7
 Nckap5l
NCK-associated protein 5-like
chr16_-_85173692 0.110 ENSMUST00000005406.10
 App
amyloid beta (A4) precursor protein
chr4_+_148000722 0.104 ENSMUST00000103230.4
 Nppa
natriuretic peptide type A
chr4_-_108625216 0.102 ENSMUST00000166069.1
 Gm20731
predicted gene, 20731
chr2_+_23069210 0.099 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr7_+_128246812 0.096 ENSMUST00000164710.1
ENSMUST00000070656.5
 Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr17_-_56609689 0.095 ENSMUST00000052832.5
 2410015M20Rik
RIKEN cDNA 2410015M20 gene
chr15_+_76351303 0.084 ENSMUST00000023212.8
ENSMUST00000160172.1
 Maf1

MAF1 homolog (S. cerevisiae)

chr10_-_127311740 0.069 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chr11_-_78550777 0.068 ENSMUST00000103242.4
 Tmem97
transmembrane protein 97
chr2_-_127792467 0.063 ENSMUST00000135091.1
 1500011K16Rik
RIKEN cDNA 1500011K16 gene
chr11_-_101987004 0.061 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr2_-_73892530 0.058 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
 Atf2



activating transcription factor 2



chr2_+_129800451 0.051 ENSMUST00000165413.2
ENSMUST00000166282.2
 Stk35

serine/threonine kinase 35

chr12_+_74297474 0.045 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr6_+_115853470 0.036 ENSMUST00000112925.1
ENSMUST00000112923.1
ENSMUST00000038234.6
 Ift122


intraflagellar transport 122


chr2_+_69897220 0.029 ENSMUST00000055758.9
ENSMUST00000112251.2
 Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr7_+_128246953 0.024 ENSMUST00000167965.1
 Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr11_-_96977660 0.017 ENSMUST00000107626.1
ENSMUST00000107624.1
 Sp2

Sp2 transcription factor

chr9_+_44773191 0.010 ENSMUST00000147559.1
 Ift46
intraflagellar transport 46
chr2_+_32288317 0.008 ENSMUST00000131712.1
ENSMUST00000133113.1
ENSMUST00000081670.6
ENSMUST00000147707.1
ENSMUST00000129193.1
 Golga2




golgi autoantigen, golgin subfamily a, 2





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.5 1.5 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.4 1.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.2 1.7 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.2 0.6 GO:0045204 MAPK export from nucleus(GO:0045204)
0.2 1.8 GO:0007379 segment specification(GO:0007379)
0.1 0.9 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.3 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.1 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.2 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.1 0.6 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 2.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.2 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.0 0.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 1.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.1 GO:0071873 response to norepinephrine(GO:0071873)
0.0 0.4 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.1 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.1 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.0 0.4 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 0.4 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 1.0 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.4 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 0.2 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.0 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.5 GO:0007528 neuromuscular junction development(GO:0007528)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0042581 specific granule(GO:0042581)
0.1 1.6 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.5 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.3 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.6 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 1.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.1 GO:1990391 DNA repair complex(GO:1990391)
0.0 2.5 GO:0005901 caveola(GO:0005901)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.6 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 0.9 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 1.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.5 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.6 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1 0.3 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.4 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 2.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0080084 RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.6 GO:0016414 O-octanoyltransferase activity(GO:0016414)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)