Motif ID: Nkx2-9

Z-value: 0.444


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_56613291-0.067.9e-01Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 128 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_75455957 1.054 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr11_+_117849223 0.963 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr10_+_88091070 0.954 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr16_-_33380717 0.759 ENSMUST00000180923.1
 1700007L15Rik
RIKEN cDNA 1700007L15 gene
chrX_-_165004829 0.737 ENSMUST00000114890.2
 Gm17604
predicted gene, 17604
chr2_+_173022360 0.724 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chrX_+_135993820 0.721 ENSMUST00000058119.7
 Arxes2
adipocyte-related X-chromosome expressed sequence 2
chr4_+_36952930 0.715 ENSMUST00000144029.1
 Gm12371
predicted gene 12371
chr2_-_129699833 0.690 ENSMUST00000028883.5
 Pdyn
prodynorphin
chr2_-_152398046 0.634 ENSMUST00000063332.8
ENSMUST00000182625.1
 Sox12

SRY-box containing gene 12

chr11_+_117849286 0.578 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr4_-_72852622 0.527 ENSMUST00000179234.1
ENSMUST00000078617.4
 Aldoart1

aldolase 1 A, retrogene 1

chr11_+_88718442 0.521 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr11_-_100759740 0.506 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr7_+_4925802 0.490 ENSMUST00000057612.7
 Ssc5d
scavenger receptor cysteine rich domain containing (5 domains)
chr3_-_37125943 0.475 ENSMUST00000029275.5
 Il2
interleukin 2
chrX_-_95658392 0.467 ENSMUST00000120620.1
 Zc4h2
zinc finger, C4H2 domain containing
chr10_+_14523062 0.458 ENSMUST00000096020.5
 Gm10335
predicted gene 10335
chr18_+_77185815 0.456 ENSMUST00000079618.4
 St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr7_-_142576492 0.448 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.2 1.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.3 1.0 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.5 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 0.5 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 0.4 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0 0.4 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.3 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.3 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 0.3 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.1 0.2 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.0 0.2 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 0.2 GO:0048318 axial mesoderm development(GO:0048318)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.5 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.7 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.3 GO:0070069 cytochrome complex(GO:0070069)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.2 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0043027 Ran GTPase binding(GO:0008536) cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.9 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.7 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.4 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.1 0.3 GO:0070878 primary miRNA binding(GO:0070878)
0.1 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.3 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.3 GO:0070402 NADPH binding(GO:0070402)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0034711 inhibin binding(GO:0034711)