Motif ID: Nkx3-2

Z-value: 0.654


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 2.857 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr10_+_38965515 2.055 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr15_-_88978958 2.016 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr9_-_58313189 1.946 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr16_+_41532851 1.827 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr9_+_57940104 1.455 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr6_-_125494754 1.375 ENSMUST00000032492.8
 Cd9
CD9 antigen
chr15_-_66969616 1.333 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr11_+_3332426 1.297 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_+_25054396 1.254 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
 Nsmf




NMDA receptor synaptonuclear signaling and neuronal migration factor




chr6_-_138421379 1.198 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr5_-_139130159 1.178 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr3_+_86070915 1.161 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr8_+_104101625 1.132 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr8_+_104340594 1.111 ENSMUST00000034343.4
 Cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr1_+_172341197 1.104 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr14_+_80000292 1.096 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr8_-_13200576 1.013 ENSMUST00000165605.2
 Grtp1
GH regulated TBC protein 1
chr6_+_117168535 1.000 ENSMUST00000112866.1
ENSMUST00000112871.1
ENSMUST00000073043.4
 Cxcl12


chemokine (C-X-C motif) ligand 12


chr4_-_4138432 0.974 ENSMUST00000070375.7
 Penk
preproenkephalin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 2.2 GO:0071371 cellular response to electrical stimulus(GO:0071257) cellular response to gonadotropin stimulus(GO:0071371)
0.1 2.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.4 1.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 1.7 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.3 1.5 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.2 1.5 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 1.5 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 1.4 GO:0030913 paranodal junction assembly(GO:0030913)
0.2 1.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 1.3 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.1 1.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.2 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.4 1.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.4 1.1 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.3 1.1 GO:0009597 detection of virus(GO:0009597)
0.2 1.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.2 1.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 1.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 2.9 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.1 2.2 GO:0097440 apical dendrite(GO:0097440)
0.1 2.1 GO:0005605 basal lamina(GO:0005605)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.4 1.5 GO:0032280 symmetric synapse(GO:0032280)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.0 1.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.1 GO:0097449 astrocyte projection(GO:0097449)
0.1 1.1 GO:0042581 specific granule(GO:0042581)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 0.8 GO:0036125 mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125)
0.1 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.8 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.8 2.5 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.1 2.5 GO:0045296 cadherin binding(GO:0045296)
0.0 2.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.0 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 1.5 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.5 GO:0038191 neuropilin binding(GO:0038191)
0.4 1.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.4 1.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 1.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 1.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 0.9 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 0.8 GO:0016508 long-chain-enoyl-CoA hydratase activity(GO:0016508) long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.1 0.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.8 GO:0008758 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.2 0.7 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)