Motif ID: Nkx3-2
Z-value: 0.654
Transcription factors associated with Nkx3-2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx3-2 | ENSMUSG00000049691.7 | Nkx3-2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.9 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
0.4 | 1.1 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
0.4 | 1.1 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
0.3 | 1.5 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
0.3 | 1.1 | GO:0009597 | detection of virus(GO:0009597) |
0.3 | 0.8 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
0.2 | 1.0 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
0.2 | 0.7 | GO:0021893 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) |
0.2 | 1.4 | GO:0030913 | paranodal junction assembly(GO:0030913) |
0.2 | 0.6 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
0.2 | 1.3 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
0.2 | 1.1 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
0.2 | 0.5 | GO:1900060 | negative regulation of ceramide biosynthetic process(GO:1900060) |
0.2 | 0.8 | GO:0044838 | cell quiescence(GO:0044838) |
0.2 | 2.2 | GO:0071371 | cellular response to electrical stimulus(GO:0071257) cellular response to gonadotropin stimulus(GO:0071371) |
0.2 | 0.7 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
0.2 | 1.5 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
0.2 | 1.1 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
0.2 | 3.3 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
0.1 | 1.3 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
0.1 | 0.3 | GO:0003289 | atrial septum primum morphogenesis(GO:0003289) |
0.1 | 0.4 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
0.1 | 0.7 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) regulation of peroxisome size(GO:0044375) |
0.1 | 1.1 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.1 | 0.2 | GO:0035910 | ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
0.1 | 0.2 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
0.1 | 0.5 | GO:0070100 | negative regulation of chemokine-mediated signaling pathway(GO:0070100) |
0.1 | 0.7 | GO:0048625 | myoblast fate commitment(GO:0048625) |
0.1 | 0.5 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
0.1 | 0.3 | GO:0042636 | negative regulation of hair cycle(GO:0042636) negative regulation of hair follicle development(GO:0051799) |
0.1 | 0.2 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
0.1 | 0.3 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
0.1 | 0.2 | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) |
0.1 | 0.5 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
0.1 | 0.1 | GO:0070889 | platelet alpha granule organization(GO:0070889) |
0.1 | 0.9 | GO:0018126 | protein hydroxylation(GO:0018126) |
0.1 | 0.9 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.1 | 0.4 | GO:0070166 | enamel mineralization(GO:0070166) |
0.1 | 2.1 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.1 | 0.4 | GO:0032811 | negative regulation of epinephrine secretion(GO:0032811) |
0.1 | 1.5 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
0.1 | 0.5 | GO:0006013 | mannose metabolic process(GO:0006013) |
0.1 | 0.6 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
0.1 | 0.4 | GO:0070813 | hydrogen sulfide metabolic process(GO:0070813) |
0.1 | 1.2 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.1 | 0.2 | GO:0030167 | proteoglycan catabolic process(GO:0030167) regulation of endothelial tube morphogenesis(GO:1901509) |
0.1 | 0.8 | GO:0007263 | nitric oxide mediated signal transduction(GO:0007263) |
0.1 | 0.3 | GO:0051697 | protein delipidation(GO:0051697) |
0.0 | 0.3 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glycolytic process through glucose-1-phosphate(GO:0061622) glucose catabolic process to pyruvate(GO:0061718) |
0.0 | 0.4 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
0.0 | 0.2 | GO:0021764 | amygdala development(GO:0021764) |
0.0 | 0.2 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
0.0 | 0.2 | GO:0032298 | positive regulation of DNA-dependent DNA replication initiation(GO:0032298) |
0.0 | 0.6 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
0.0 | 0.2 | GO:0032439 | endosome localization(GO:0032439) |
0.0 | 0.4 | GO:0035814 | negative regulation of renal sodium excretion(GO:0035814) |
0.0 | 0.2 | GO:0033580 | protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125) |
0.0 | 0.4 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
0.0 | 0.2 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
0.0 | 0.5 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
0.0 | 0.7 | GO:0046321 | positive regulation of fatty acid oxidation(GO:0046321) |
0.0 | 0.3 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
0.0 | 0.1 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
0.0 | 1.2 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.0 | 0.4 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
0.0 | 0.3 | GO:0090166 | Golgi disassembly(GO:0090166) |
0.0 | 0.4 | GO:0002237 | response to molecule of bacterial origin(GO:0002237) response to lipopolysaccharide(GO:0032496) |
0.0 | 0.6 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.0 | 0.1 | GO:0032627 | interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) |
0.0 | 0.6 | GO:0001963 | synaptic transmission, dopaminergic(GO:0001963) |
0.0 | 0.3 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
0.0 | 1.7 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
0.0 | 0.1 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
0.0 | 0.3 | GO:1990403 | embryonic brain development(GO:1990403) |
0.0 | 1.5 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
0.0 | 0.6 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
0.0 | 0.1 | GO:0019085 | early viral transcription(GO:0019085) |
0.0 | 0.3 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
0.0 | 1.0 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.0 | 0.1 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
0.0 | 0.3 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
0.0 | 0.2 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
0.0 | 0.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
0.0 | 0.1 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
0.0 | 0.8 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
0.0 | 0.8 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
0.0 | 0.1 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
0.0 | 0.1 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
0.0 | 0.3 | GO:0001893 | maternal placenta development(GO:0001893) |
0.0 | 0.3 | GO:0009303 | rRNA transcription(GO:0009303) |
0.0 | 0.0 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) pulmonary myocardium development(GO:0003350) subthalamus development(GO:0021539) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.5 | GO:0032280 | symmetric synapse(GO:0032280) |
0.3 | 0.8 | GO:0036125 | mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125) |
0.2 | 0.6 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
0.2 | 2.9 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
0.1 | 0.5 | GO:0035339 | SPOTS complex(GO:0035339) |
0.1 | 0.5 | GO:0097227 | sperm annulus(GO:0097227) |
0.1 | 0.3 | GO:0048179 | activin receptor complex(GO:0048179) |
0.1 | 0.4 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.1 | 0.4 | GO:1990130 | Iml1 complex(GO:1990130) |
0.1 | 0.3 | GO:0031983 | vesicle lumen(GO:0031983) |
0.1 | 0.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.1 | 2.1 | GO:0005605 | basal lamina(GO:0005605) |
0.1 | 0.4 | GO:0001652 | granular component(GO:0001652) |
0.1 | 1.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.1 | 1.1 | GO:0097449 | astrocyte projection(GO:0097449) |
0.1 | 0.8 | GO:0044327 | dendritic spine head(GO:0044327) |
0.1 | 0.7 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.1 | 1.1 | GO:0042581 | specific granule(GO:0042581) |
0.1 | 0.4 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
0.1 | 0.3 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
0.1 | 0.5 | GO:0043083 | synaptic cleft(GO:0043083) |
0.1 | 0.2 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
0.1 | 2.2 | GO:0097440 | apical dendrite(GO:0097440) |
0.1 | 0.4 | GO:0033263 | CORVET complex(GO:0033263) |
0.0 | 0.2 | GO:1990131 | EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.0 | 0.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.4 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.5 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 3.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
0.0 | 0.0 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.0 | 0.1 | GO:0031091 | platelet alpha granule(GO:0031091) |
0.0 | 1.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.0 | 1.8 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 0.2 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
0.0 | 0.2 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
0.0 | 0.5 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.4 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.0 | 3.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 0.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
0.0 | 0.8 | GO:0031201 | SNARE complex(GO:0031201) |
0.0 | 1.1 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 1.2 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
0.0 | 0.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 1.3 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 2.5 | GO:0043912 | D-lysine oxidase activity(GO:0043912) |
0.5 | 2.9 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
0.4 | 1.3 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
0.4 | 1.1 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
0.2 | 0.9 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
0.2 | 1.5 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.2 | 0.6 | GO:0036004 | GAF domain binding(GO:0036004) |
0.2 | 0.8 | GO:0016508 | long-chain-enoyl-CoA hydratase activity(GO:0016508) long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
0.2 | 0.7 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
0.1 | 1.5 | GO:0038191 | neuropilin binding(GO:0038191) |
0.1 | 0.3 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
0.1 | 0.3 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
0.1 | 0.3 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
0.1 | 1.1 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.1 | 0.4 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
0.1 | 0.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.1 | 1.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.1 | 0.4 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
0.1 | 0.3 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
0.1 | 0.3 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
0.1 | 0.5 | GO:0048495 | Roundabout binding(GO:0048495) |
0.1 | 0.2 | GO:0035939 | microsatellite binding(GO:0035939) |
0.1 | 0.8 | GO:0008758 | thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606) |
0.1 | 0.4 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
0.1 | 0.2 | GO:0035473 | lipase binding(GO:0035473) |
0.1 | 2.5 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 0.5 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.0 | 0.3 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
0.0 | 0.4 | GO:0000182 | rDNA binding(GO:0000182) |
0.0 | 0.4 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
0.0 | 0.1 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
0.0 | 0.7 | GO:0045295 | gamma-catenin binding(GO:0045295) |
0.0 | 0.6 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.0 | 0.4 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
0.0 | 0.4 | GO:0004889 | acetylcholine-activated cation-selective channel activity(GO:0004889) |
0.0 | 0.5 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.7 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
0.0 | 1.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 0.1 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
0.0 | 2.2 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.0 | 0.2 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
0.0 | 0.1 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.0 | 0.6 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
0.0 | 0.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.0 | 0.1 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
0.0 | 1.3 | GO:0005518 | collagen binding(GO:0005518) |
0.0 | 0.1 | GO:0015464 | acetylcholine receptor activity(GO:0015464) |
0.0 | 2.0 | GO:0008565 | protein transporter activity(GO:0008565) |
0.0 | 1.6 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
0.0 | 0.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.0 | 0.5 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.0 | 0.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.0 | 0.1 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
0.0 | 0.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.0 | 0.6 | GO:0052771 | coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771) |
0.0 | 0.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.0 | 0.1 | GO:0002094 | polyprenyltransferase activity(GO:0002094) |
0.0 | 0.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.1 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |