Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.653

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_1016652260.213.4e-01Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_49757257 6.585 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr5_-_62766153 5.325 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_-_8710734 4.267 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_+_18818895 4.078 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr14_-_118052235 3.780 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr11_-_98053415 3.700 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr2_+_116067213 3.335 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr15_-_8710409 3.311 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_101377897 3.001 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr15_+_25773985 2.852 ENSMUST00000125667.1
 Myo10
myosin X
chr5_-_62765618 2.337 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_62419668 2.322 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr13_+_94083490 2.242 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr8_+_23411490 2.198 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr2_-_116067391 2.148 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr5_-_84417359 2.124 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr16_+_42907563 2.013 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr17_+_3532554 1.988 ENSMUST00000168560.1
 Cldn20
claudin 20
chrM_+_11734 1.742 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr3_+_66219909 1.706 ENSMUST00000029421.5
 Ptx3
pentraxin related gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 7.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 6.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 4.0 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.6 3.8 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 3.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 3.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 2.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 2.4 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.4 2.3 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.7 2.2 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 2.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 1.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.4 1.8 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.6 1.7 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0 1.7 GO:0006275 regulation of DNA replication(GO:0006275)
0.5 1.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.5 1.6 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 1.6 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.1 1.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 1.5 GO:0007608 sensory perception of smell(GO:0007608)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0043205 fibril(GO:0043205)
0.1 5.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 4.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 3.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.9 GO:0072562 blood microparticle(GO:0072562)
0.1 2.8 GO:0016459 myosin complex(GO:0016459)
0.0 2.1 GO:0070469 respiratory chain(GO:0070469)
0.0 2.0 GO:0031201 SNARE complex(GO:0031201)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.7 GO:0071565 nBAF complex(GO:0071565)
0.0 1.7 GO:0097440 apical dendrite(GO:0097440)
0.1 1.5 GO:0000124 SAGA complex(GO:0000124)
0.0 1.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.2 1.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.0 GO:0032279 asymmetric synapse(GO:0032279)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.5 7.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 5.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.0 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.3 3.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 3.5 GO:0030507 spectrin binding(GO:0030507)
0.0 2.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 2.3 GO:0001618 virus receptor activity(GO:0001618)
0.3 2.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 1.7 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 1.6 GO:0050693 LBD domain binding(GO:0050693)
0.0 1.6 GO:0008276 protein methyltransferase activity(GO:0008276)
0.2 1.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)