Motif ID: Nkx6-2

Z-value: 0.563


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.405.6e-02Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 123 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22161450 1.822 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr6_-_144209471 1.439 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 1.384 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr4_-_97584605 1.065 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_126830632 1.054 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr10_+_37139558 1.048 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr6_-_144209448 1.047 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr4_-_97584612 1.017 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_126830786 0.914 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr17_-_48432723 0.882 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr8_-_61902669 0.864 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr19_+_58728887 0.793 ENSMUST00000048644.5
 Pnliprp1
pancreatic lipase related protein 1
chr15_-_13173607 0.772 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr10_+_26822560 0.696 ENSMUST00000135866.1
 Arhgap18
Rho GTPase activating protein 18
chr1_+_34005872 0.596 ENSMUST00000182296.1
 Dst
dystonin
chr4_-_83285141 0.588 ENSMUST00000150522.1
 Ttc39b
tetratricopeptide repeat domain 39B
chr3_+_96601084 0.540 ENSMUST00000062058.3
 Lix1l
Lix1-like
chr7_-_45062393 0.450 ENSMUST00000129101.1
 Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr1_+_66321708 0.444 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr2_-_33718789 0.440 ENSMUST00000130532.1
 9430024E24Rik
RIKEN cDNA 9430024E24 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 2.1 GO:0051028 mRNA transport(GO:0051028)
0.0 1.2 GO:0021954 central nervous system neuron development(GO:0021954)
0.1 0.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.9 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 0.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.5 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.5 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.4 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.2 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.0 0.2 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0007320 insemination(GO:0007320)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 1.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:0031673 H zone(GO:0031673)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0046930 pore complex(GO:0046930)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.9 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.4 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 0.4 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)