Motif ID: Nkx6-2

Z-value: 0.563


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.405.6e-02Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_22161450 1.822 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr6_-_144209471 1.439 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 1.384 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr4_-_97584605 1.065 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_126830632 1.054 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr10_+_37139558 1.048 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr6_-_144209448 1.047 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr4_-_97584612 1.017 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_126830786 0.914 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr17_-_48432723 0.882 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr8_-_61902669 0.864 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr19_+_58728887 0.793 ENSMUST00000048644.5
 Pnliprp1
pancreatic lipase related protein 1
chr15_-_13173607 0.772 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr10_+_26822560 0.696 ENSMUST00000135866.1
 Arhgap18
Rho GTPase activating protein 18
chr1_+_34005872 0.596 ENSMUST00000182296.1
 Dst
dystonin
chr4_-_83285141 0.588 ENSMUST00000150522.1
 Ttc39b
tetratricopeptide repeat domain 39B
chr3_+_96601084 0.540 ENSMUST00000062058.3
 Lix1l
Lix1-like
chr7_-_45062393 0.450 ENSMUST00000129101.1
 Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr1_+_66321708 0.444 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr2_-_33718789 0.440 ENSMUST00000130532.1
 9430024E24Rik
RIKEN cDNA 9430024E24 gene
chr4_-_117182623 0.426 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr5_+_92809372 0.414 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr1_+_194619815 0.405 ENSMUST00000027952.5
 Plxna2
plexin A2
chr4_-_21767173 0.397 ENSMUST00000029915.5
 Tstd3
thiosulfate sulfurtransferase (rhodanese)-like domain containing 3
chr1_+_66322102 0.364 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr3_+_103575231 0.355 ENSMUST00000121834.1
 Syt6
synaptotagmin VI
chr3_+_55461758 0.332 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr5_+_92683625 0.327 ENSMUST00000168878.1
 Shroom3
shroom family member 3
chr10_+_88201158 0.310 ENSMUST00000171151.2
 Ccdc53
coiled-coil domain containing 53
chr9_+_65890237 0.306 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr6_-_102464667 0.297 ENSMUST00000032159.6
 Cntn3
contactin 3
chr10_-_37138863 0.288 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr10_+_88201223 0.285 ENSMUST00000182619.1
 Ccdc53
coiled-coil domain containing 53
chr3_-_96220880 0.280 ENSMUST00000090782.3
 Hist2h2ac
histone cluster 2, H2ac
chr5_+_66676098 0.279 ENSMUST00000031131.9
 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr18_-_74207771 0.276 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr9_-_35558522 0.275 ENSMUST00000034612.5
 Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr4_-_138913915 0.271 ENSMUST00000097830.3
 Otud3
OTU domain containing 3
chr5_+_123142187 0.257 ENSMUST00000174836.1
ENSMUST00000163030.2
 Setd1b

SET domain containing 1B

chr10_+_88201117 0.251 ENSMUST00000182183.1
 Ccdc53
coiled-coil domain containing 53
chr5_+_25246775 0.246 ENSMUST00000144971.1
 Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr10_+_88201087 0.234 ENSMUST00000020248.9
 Ccdc53
coiled-coil domain containing 53
chr9_+_96259246 0.232 ENSMUST00000179065.1
ENSMUST00000165768.2
 Tfdp2

transcription factor Dp 2

chr15_+_99006056 0.229 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr11_+_52360824 0.228 ENSMUST00000102758.1
 Vdac1
voltage-dependent anion channel 1
chr12_-_80760541 0.218 ENSMUST00000073251.6
 Ccdc177
coiled-coil domain containing 177
chr7_+_43690418 0.215 ENSMUST00000056329.6
 Klk14
kallikrein related-peptidase 14
chr16_-_76403673 0.213 ENSMUST00000052867.7
 Gm9843
predicted gene 9843
chr2_+_69789621 0.209 ENSMUST00000151298.1
ENSMUST00000028494.2
 Phospho2

phosphatase, orphan 2

chr9_+_96258697 0.201 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr2_+_69789647 0.199 ENSMUST00000112266.1
 Phospho2
phosphatase, orphan 2
chr15_-_81104999 0.199 ENSMUST00000109579.2
 Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr18_-_42899294 0.192 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr8_-_107439585 0.187 ENSMUST00000077208.4
 Rps26-ps1
ribosomal protein S26, pseudogene 1
chrX_-_43274786 0.182 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr11_+_69838514 0.181 ENSMUST00000133967.1
ENSMUST00000094065.4
 Tmem256

transmembrane protein 256

chr2_+_3114220 0.175 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr4_-_133756769 0.175 ENSMUST00000008024.6
 Arid1a
AT rich interactive domain 1A (SWI-like)
chr4_+_150853919 0.174 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr3_+_103575275 0.171 ENSMUST00000090697.4
 Syt6
synaptotagmin VI
chr4_+_140701466 0.163 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr11_+_98863610 0.161 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr11_-_107348130 0.160 ENSMUST00000134763.1
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr18_+_6332587 0.157 ENSMUST00000097682.2
 Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr13_+_109926832 0.150 ENSMUST00000117420.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr11_+_62879449 0.149 ENSMUST00000014321.4
 Tvp23b
trans-golgi network vesicle protein 23B
chr5_+_140419248 0.149 ENSMUST00000100507.3
 Eif3b
eukaryotic translation initiation factor 3, subunit B
chrX_-_59567348 0.145 ENSMUST00000124402.1
 Fgf13
fibroblast growth factor 13
chr7_+_39588931 0.145 ENSMUST00000178791.1
ENSMUST00000098511.3
 Gm2058

predicted gene 2058

chr9_-_22117123 0.142 ENSMUST00000013966.6
 Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr3_+_96221111 0.139 ENSMUST00000090781.6
 Hist2h2be
histone cluster 2, H2be
chr11_-_31671727 0.137 ENSMUST00000109415.1
 Bod1
biorientation of chromosomes in cell division 1
chr16_+_44394771 0.136 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr5_-_122821298 0.135 ENSMUST00000086216.4
 Anapc5
anaphase-promoting complex subunit 5
chr17_-_78684262 0.132 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr1_-_185329331 0.131 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
 Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr3_+_19894855 0.126 ENSMUST00000059704.4
 4632415L05Rik
RIKEN cDNA 4632415L05 gene
chr10_+_79910856 0.124 ENSMUST00000181321.1
 Gm26602
predicted gene, 26602
chr4_+_98546919 0.123 ENSMUST00000030290.7
 Inadl
InaD-like (Drosophila)
chr6_+_125049903 0.123 ENSMUST00000112413.1
 Acrbp
proacrosin binding protein
chr7_-_103741322 0.120 ENSMUST00000051346.2
 Olfr629
olfactory receptor 629
chr1_-_9944103 0.119 ENSMUST00000182498.1
ENSMUST00000182742.1
ENSMUST00000182580.1
 Snhg6


small nucleolar RNA host gene (non-protein coding) 6


chr4_+_98546710 0.115 ENSMUST00000102792.3
 Inadl
InaD-like (Drosophila)
chr6_-_13839916 0.114 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr18_+_34840575 0.110 ENSMUST00000043484.7
 Reep2
receptor accessory protein 2
chr9_-_113708209 0.109 ENSMUST00000111861.3
ENSMUST00000035086.6
 Pdcd6ip

programmed cell death 6 interacting protein

chr3_+_106113229 0.109 ENSMUST00000079132.5
ENSMUST00000139086.1
 Chia

chitinase, acidic

chr16_-_16829276 0.106 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr2_-_174346712 0.105 ENSMUST00000168292.1
 Gm20721
predicted gene, 20721
chr5_-_51553896 0.101 ENSMUST00000132734.1
 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr11_-_109995743 0.098 ENSMUST00000106669.2
 Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr19_-_58454435 0.097 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr15_-_73061204 0.093 ENSMUST00000089770.3
ENSMUST00000170633.1
ENSMUST00000168191.1
 Trappc9


trafficking protein particle complex 9


chr7_+_25228687 0.087 ENSMUST00000169914.1
 9130221H12Rik
RIKEN cDNA 9130221H12 gene
chr7_+_3645267 0.081 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr4_+_3940747 0.079 ENSMUST00000119403.1
 Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr17_+_35861343 0.077 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr4_-_136835843 0.077 ENSMUST00000105846.2
ENSMUST00000059287.7
ENSMUST00000105845.2
 Ephb2


Eph receptor B2


chr17_+_82539258 0.075 ENSMUST00000097278.3
 Gm6594
predicted pseudogene 6594
chr18_-_31911903 0.070 ENSMUST00000054984.6
 Sft2d3
SFT2 domain containing 3
chr10_+_18407658 0.067 ENSMUST00000037341.7
 Nhsl1
NHS-like 1
chr8_+_93810832 0.059 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr18_+_4993795 0.058 ENSMUST00000153016.1
 Svil
supervillin
chr4_+_127172866 0.055 ENSMUST00000106094.2
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr18_+_57142782 0.054 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr2_-_84650490 0.052 ENSMUST00000066177.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr14_+_29978337 0.050 ENSMUST00000016115.4
 Actr8
ARP8 actin-related protein 8
chr18_+_61639542 0.048 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr2_-_84650714 0.048 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
 Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr2_+_163694015 0.046 ENSMUST00000109400.2
 Pkig
protein kinase inhibitor, gamma
chr2_-_84650676 0.045 ENSMUST00000067232.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_45117349 0.042 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr1_+_184034381 0.038 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr2_-_84650760 0.036 ENSMUST00000111691.1
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr3_+_10088173 0.032 ENSMUST00000061419.7
 Gm9833
predicted gene 9833
chr11_+_115933282 0.027 ENSMUST00000140991.1
 Sap30bp
SAP30 binding protein
chr8_+_46986913 0.026 ENSMUST00000039840.7
ENSMUST00000119686.1
 Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chrX_-_59568068 0.018 ENSMUST00000119833.1
ENSMUST00000131319.1
 Fgf13

fibroblast growth factor 13

chr11_-_109995775 0.017 ENSMUST00000020948.8
 Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr11_-_115933464 0.014 ENSMUST00000021097.3
 Recql5
RecQ protein-like 5
chr4_-_3938354 0.011 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr4_-_150003130 0.002 ENSMUST00000084117.6
 H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr3_+_68572245 0.001 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 0.5 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)
0.1 0.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.2 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.9 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.4 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.2 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.0 0.2 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.0 0.2 GO:0007320 insemination(GO:0007320)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.2 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.2 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.0 0.5 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.2 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.1 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.1 GO:0032596 protein transport into membrane raft(GO:0032596)
0.0 2.1 GO:0051028 mRNA transport(GO:0051028)
0.0 0.2 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.0 0.1 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 0.1 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.0 1.2 GO:0021954 central nervous system neuron development(GO:0021954)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0031673 H zone(GO:0031673)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.0 3.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 1.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.4 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.9 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)