Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.563

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene SymbolEntrez IDGene Name
Barx2 ENSMUSG00000032033.10 Barx2
Dbx2 ENSMUSG00000045608.6 Dbx2
Nkx6-3 ENSMUSG00000063672.6 Nkx6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dbx2mm10_v2_chr15_-_95655960_956559600.213.3e-01Click!


Activity profile for motif Nkx6-3_Dbx2_Barx2.

activity profile for motif Nkx6-3_Dbx2_Barx2


Sorted Z-values histogram for motif Nkx6-3_Dbx2_Barx2

Sorted Z-values for motif Nkx6-3_Dbx2_Barx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-3_Dbx2_Barx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 128 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_136143497 2.277 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr13_+_94083490 2.010 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr14_+_80000292 1.730 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr8_-_21906412 1.609 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr11_+_109543694 1.541 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr5_-_62766153 1.225 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_118961578 1.168 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr5_-_70842617 1.152 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr15_-_8710734 0.998 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_160619971 0.907 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr6_-_137169710 0.851 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr3_-_116712644 0.820 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr17_-_45659312 0.768 ENSMUST00000120717.1
 Capn11
calpain 11
chr15_-_8710409 0.764 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_+_83732438 0.748 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr2_+_109917639 0.684 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr4_-_14621805 0.681 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr17_-_81649607 0.606 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr8_+_94172618 0.580 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr13_-_105271039 0.557 ENSMUST00000069686.6
 Rnf180
ring finger protein 180

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0071398 cellular response to fatty acid(GO:0071398)
0.4 1.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 1.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.2 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.2 0.8 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 0.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 0.7 GO:1901642 purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642) nucleotide transmembrane transport(GO:1901679)
0.1 0.6 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 0.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 0.6 GO:0019532 oxalate transport(GO:0019532)
0.1 0.6 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.2 0.5 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.1 0.5 GO:1900170 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0 0.5 GO:0033572 transferrin transport(GO:0033572)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.4 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.4 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 0.3 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.3 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0043205 fibril(GO:0043205)
0.1 1.7 GO:0042581 specific granule(GO:0042581)
0.1 1.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.9 GO:0045296 cadherin binding(GO:0045296)
0.4 1.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 1.5 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.4 1.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 1.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.2 0.7 GO:0015217 ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 0.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 0.6 GO:0019770 IgG receptor activity(GO:0019770)
0.2 0.6 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.5 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.3 GO:0048406 nerve growth factor binding(GO:0048406)