Motif ID: Nr1h2

Z-value: 1.126


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.845.6e-07Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

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Top targets:


Showing 1 to 20 of 120 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 8.504 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_-_97417730 7.316 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr11_-_60210410 5.313 ENSMUST00000144942.1
 Srebf1
sterol regulatory element binding transcription factor 1
chr16_-_37384915 4.772 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr8_-_84773381 4.180 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr3_+_62419668 3.498 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr16_-_37384940 3.427 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr15_+_79895017 2.844 ENSMUST00000023054.7
 Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chrX_-_102644210 2.755 ENSMUST00000052012.7
ENSMUST00000043596.5
ENSMUST00000119229.1
ENSMUST00000122022.1
ENSMUST00000120270.1
ENSMUST00000113611.2
 Phka1





phosphorylase kinase alpha 1





chr5_-_124327883 2.647 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr7_+_97453204 2.483 ENSMUST00000050732.7
ENSMUST00000121987.1
 Kctd14

potassium channel tetramerisation domain containing 14

chr2_-_113829069 2.470 ENSMUST00000024005.7
 Scg5
secretogranin V
chr13_-_12461432 2.418 ENSMUST00000143693.1
ENSMUST00000144283.1
ENSMUST00000099820.3
ENSMUST00000135166.1
 Lgals8



lectin, galactose binding, soluble 8



chr6_+_90462562 2.283 ENSMUST00000032174.5
 Klf15
Kruppel-like factor 15
chr11_+_84179792 2.230 ENSMUST00000137500.2
ENSMUST00000130012.2
 Acaca

acetyl-Coenzyme A carboxylase alpha

chr10_-_109823585 2.161 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr1_+_58711488 2.145 ENSMUST00000097722.2
ENSMUST00000114313.1
 Cflar

CASP8 and FADD-like apoptosis regulator

chr11_+_84179852 2.093 ENSMUST00000136463.2
 Acaca
acetyl-Coenzyme A carboxylase alpha
chr13_+_44729794 2.044 ENSMUST00000172830.1
 Jarid2
jumonji, AT rich interactive domain 2
chr17_-_79715034 1.887 ENSMUST00000024894.1
 Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 8.5 GO:0055099 regulation of Cdc42 protein signal transduction(GO:0032489) response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.2 8.2 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.3 7.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.7 5.3 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
1.1 4.3 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.3 4.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 3.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.5 2.8 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0 2.8 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.1 2.5 GO:0016486 peptide hormone processing(GO:0016486)
0.4 2.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.5 2.3 GO:0046208 spermine catabolic process(GO:0046208)
0.2 2.3 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.7 2.1 GO:0014891 striated muscle atrophy(GO:0014891)
0.2 2.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.6 1.9 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.8 1.7 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.1 1.7 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 1.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.6 GO:0060487 lung epithelial cell differentiation(GO:0060487)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 7.4 GO:0031201 SNARE complex(GO:0031201)
0.4 2.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 2.6 GO:0005776 autophagosome(GO:0005776)
0.4 2.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 2.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.4 1.4 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.4 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.1 GO:0043196 varicosity(GO:0043196)
0.1 0.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 0.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 0.8 GO:0045098 type III intermediate filament(GO:0045098)
0.2 0.7 GO:0001533 cornified envelope(GO:0001533)
0.1 0.7 GO:0042382 paraspeckles(GO:0042382)
0.2 0.5 GO:0097447 dendritic tree(GO:0097447)
0.1 0.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 8.5 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.1 8.2 GO:0019905 syntaxin binding(GO:0019905)
0.0 6.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.4 4.3 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.7 2.8 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 2.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 2.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.4 GO:0030246 carbohydrate binding(GO:0030246)
0.5 2.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 2.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 2.0 GO:0032452 histone demethylase activity(GO:0032452)
0.4 1.9 GO:0070330 aromatase activity(GO:0070330)
0.3 1.7 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 1.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.5 1.4 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.2 1.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 1.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.3 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.3 1.2 GO:0070891 lipoteichoic acid binding(GO:0070891)