Motif ID: Nr2f1_Nr4a1

Z-value: 0.622

Transcription factors associated with Nr2f1_Nr4a1:

Gene SymbolEntrez IDGene Name
Nr2f1 ENSMUSG00000069171.7 Nr2f1
Nr4a1 ENSMUSG00000023034.6 Nr4a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a1mm10_v2_chr15_+_101266839_101266859-0.631.2e-03Click!
Nr2f1mm10_v2_chr13_-_78199757_781998550.511.2e-02Click!


Activity profile for motif Nr2f1_Nr4a1.

activity profile for motif Nr2f1_Nr4a1


Sorted Z-values histogram for motif Nr2f1_Nr4a1

Sorted Z-values for motif Nr2f1_Nr4a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f1_Nr4a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_43952999 2.280 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr8_-_105471481 2.031 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr2_+_126556128 2.014 ENSMUST00000141482.2
 Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
chr13_+_94875600 1.958 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr9_-_119578981 1.949 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr2_-_13011747 1.786 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr4_-_41697040 1.693 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr9_-_106656081 1.508 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr1_-_164458345 1.401 ENSMUST00000027863.7
 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr6_+_91157373 1.354 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr12_-_111672290 1.351 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr5_-_106458440 1.331 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr17_-_62606679 1.251 ENSMUST00000163332.1
 Efna5
ephrin A5
chr5_+_63649335 1.214 ENSMUST00000159584.1
 3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr12_+_61523889 1.174 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr5_+_136083916 1.085 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr11_-_100822525 1.075 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr17_+_29360923 1.062 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr5_+_136084022 1.061 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chrX_+_153006461 1.057 ENSMUST00000095755.3
 Usp51
ubiquitin specific protease 51

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 224 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0014003 oligodendrocyte development(GO:0014003)
0.2 2.9 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 2.3 GO:0050807 regulation of synapse organization(GO:0050807)
0.7 2.0 GO:0086017 Purkinje myocyte action potential(GO:0086017)
0.7 2.0 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 2.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 1.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.4 1.7 GO:0003360 brainstem development(GO:0003360)
0.1 1.5 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.4 1.4 GO:1903288 regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.2 1.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.3 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 1.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 1.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 1.2 GO:0043507 positive regulation of JUN kinase activity(GO:0043507)
0.4 1.1 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.0 1.1 GO:0014047 glutamate secretion(GO:0014047)
0.3 1.0 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 1.0 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.2 1.0 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 2.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.6 1.7 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 1.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 1.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.4 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.4 1.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 1.2 GO:0000124 SAGA complex(GO:0000124)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 1.0 GO:0045259 proton-transporting ATP synthase complex(GO:0045259)
0.0 0.9 GO:0070069 cytochrome complex(GO:0070069)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.8 GO:0032426 stereocilium tip(GO:0032426)
0.2 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 0.8 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 2.8 GO:0005096 GTPase activator activity(GO:0005096)
0.4 2.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 2.3 GO:0001047 core promoter binding(GO:0001047)
0.3 2.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 1.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4 1.5 GO:0004111 creatine kinase activity(GO:0004111)
0.3 1.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 1.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.4 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.3 GO:0033142 progesterone receptor binding(GO:0033142)
0.1 1.3 GO:0005167 neurotrophin TRK receptor binding(GO:0005167)
0.0 1.2 GO:0005109 frizzled binding(GO:0005109)
0.2 1.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 1.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.1 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 1.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 1.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)