Motif ID: Nr2f6

Z-value: 0.678


Transcription factors associated with Nr2f6:

Gene SymbolEntrez IDGene Name
Nr2f6 ENSMUSG00000002393.8 Nr2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f6mm10_v2_chr8_-_71381907_71381977-0.574.2e-03Click!


Activity profile for motif Nr2f6.

activity profile for motif Nr2f6


Sorted Z-values histogram for motif Nr2f6

Sorted Z-values for motif Nr2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 124 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_41697040 2.252 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr1_-_138847579 2.106 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr6_+_83156401 1.775 ENSMUST00000032106.4
 1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr9_+_109051153 1.769 ENSMUST00000155541.1
ENSMUST00000120305.1
ENSMUST00000154113.1
ENSMUST00000128976.1
ENSMUST00000135942.1
ENSMUST00000143754.1
 Shisa5





shisa homolog 5 (Xenopus laevis)





chr4_-_97778042 1.698 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_+_85205417 1.677 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr19_+_47228804 1.616 ENSMUST00000111807.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr15_+_89532816 1.453 ENSMUST00000167173.1
 Shank3
SH3/ankyrin domain gene 3
chr4_+_85205120 1.256 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr13_-_24761861 1.211 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr15_-_95528702 1.062 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr4_+_118409331 1.017 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr3_-_89418287 1.007 ENSMUST00000029679.3
 Cks1b
CDC28 protein kinase 1b
chr13_-_73328442 0.973 ENSMUST00000022097.5
 Ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr9_-_86695897 0.924 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr16_-_4624984 0.895 ENSMUST00000014445.6
 Pam16
presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
chr11_+_101442440 0.828 ENSMUST00000107249.1
 Rpl27
ribosomal protein L27
chr10_+_43524080 0.826 ENSMUST00000057649.6
 Gm9803
predicted gene 9803
chr6_+_86365673 0.821 ENSMUST00000071492.7
 Fam136a
family with sequence similarity 136, member A
chr7_-_89941084 0.797 ENSMUST00000075010.4
ENSMUST00000153470.1
 l7Rn6

lethal, Chr 7, Rinchik 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.1 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 2.9 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.6 2.3 GO:0003360 brainstem development(GO:0003360)
0.5 2.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 1.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.8 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 1.6 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 1.5 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 0.9 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 0.9 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 0.7 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.7 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 0.6 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.0 0.6 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.2 0.5 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 0.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.5 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.5 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 1.6 GO:0061574 ASAP complex(GO:0061574)
0.0 1.6 GO:0097440 apical dendrite(GO:0097440)
0.0 1.6 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.1 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.1 0.9 GO:0031314 mitochondrial inner membrane presequence translocase complex(GO:0005744) extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.7 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.2 0.6 GO:1990879 CST complex(GO:1990879)
0.1 0.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.5 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.4 GO:0030120 vesicle coat(GO:0030120)
0.1 0.3 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.3 GO:0070826 paraferritin complex(GO:0070826)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 1.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 1.8 GO:0050699 WW domain binding(GO:0050699)
0.0 1.6 GO:0045182 translation regulator activity(GO:0045182)
0.4 1.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 1.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 0.9 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.2 0.7 GO:0019808 polyamine binding(GO:0019808)
0.1 0.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.6 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.5 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.5 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.4 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)