Motif ID: Nr4a2

Z-value: 0.568


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57124003_571240710.693.0e-04Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_26229707 5.497 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr18_+_86711059 3.316 ENSMUST00000068423.3
Cbln2
cerebellin 2 precursor protein
chr2_+_121295437 2.078 ENSMUST00000110639.1
Map1a
microtubule-associated protein 1 A
chr13_+_94875600 1.989 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr9_-_32344237 1.975 ENSMUST00000034533.5
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr2_-_129699833 1.401 ENSMUST00000028883.5
Pdyn
prodynorphin
chr9_-_106656081 1.206 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr17_+_29360923 0.935 ENSMUST00000024810.6
Fgd2
FYVE, RhoGEF and PH domain containing 2
chr11_-_100822525 0.912 ENSMUST00000107358.2
Stat5b
signal transducer and activator of transcription 5B
chr4_-_36136463 0.808 ENSMUST00000098151.2
Lingo2
leucine rich repeat and Ig domain containing 2
chr2_+_75832168 0.640 ENSMUST00000047232.7
ENSMUST00000111952.2
Agps

alkylglycerone phosphate synthase

chr1_+_57845534 0.635 ENSMUST00000169772.1
Spats2l
spermatogenesis associated, serine-rich 2-like
chrX_-_142390334 0.626 ENSMUST00000112907.1
Acsl4
acyl-CoA synthetase long-chain family member 4
chr18_-_56975333 0.619 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chr8_+_70863127 0.613 ENSMUST00000050921.2
A230052G05Rik
RIKEN cDNA A230052G05 gene
chr13_+_93304066 0.598 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr5_+_150259922 0.573 ENSMUST00000087204.5
Fry
furry homolog (Drosophila)
chr2_+_4976113 0.532 ENSMUST00000167607.1
ENSMUST00000115010.2
Ucma

upper zone of growth plate and cartilage matrix associated

chr10_+_94147982 0.524 ENSMUST00000105290.2
Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr1_+_131910458 0.515 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr1_-_124045247 0.514 ENSMUST00000112603.2
Dpp10
dipeptidylpeptidase 10
chr9_-_22002599 0.513 ENSMUST00000115336.2
ENSMUST00000044926.5
Ccdc151

coiled-coil domain containing 151

chr6_-_124814288 0.492 ENSMUST00000172132.2
Tpi1
triosephosphate isomerase 1
chr13_+_93303757 0.459 ENSMUST00000109494.1
Homer1
homer homolog 1 (Drosophila)
chr5_+_63649335 0.450 ENSMUST00000159584.1
3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr8_-_119840522 0.423 ENSMUST00000168698.1
ENSMUST00000034285.6
Cotl1

coactosin-like 1 (Dictyostelium)

chr2_+_61593077 0.412 ENSMUST00000112495.1
ENSMUST00000112501.2
Tank

TRAF family member-associated Nf-kappa B activator

chr5_+_111581422 0.402 ENSMUST00000064930.3
C130026L21Rik
RIKEN cDNA C130026L21 gene
chr10_+_90829780 0.396 ENSMUST00000179337.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr8_-_13494479 0.390 ENSMUST00000033828.5
Gas6
growth arrest specific 6
chr6_+_96113146 0.386 ENSMUST00000122120.1
Fam19a1
family with sequence similarity 19, member A1
chr3_+_4211716 0.385 ENSMUST00000170943.1
Gm8775
predicted gene 8775
chr8_-_46211284 0.377 ENSMUST00000034049.4
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr10_+_90829835 0.374 ENSMUST00000179964.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr10_-_117224480 0.372 ENSMUST00000020382.6
Yeats4
YEATS domain containing 4
chr3_+_14578609 0.352 ENSMUST00000029069.6
ENSMUST00000165922.2
E2f5

E2F transcription factor 5

chr2_-_59160644 0.346 ENSMUST00000077687.5
Ccdc148
coiled-coil domain containing 148
chr8_+_68880491 0.338 ENSMUST00000015712.8
Lpl
lipoprotein lipase
chr10_+_110920170 0.332 ENSMUST00000020403.5
Csrp2
cysteine and glycine-rich protein 2
chr2_+_59160838 0.326 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
Pkp4


plakophilin 4


chr4_+_102760294 0.318 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr5_-_31202215 0.317 ENSMUST00000176245.1
ENSMUST00000177310.1
ENSMUST00000114590.1
Zfp513


zinc finger protein 513


chr7_-_100514800 0.314 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chrX_+_150589907 0.314 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr8_-_64733534 0.312 ENSMUST00000141021.1
Sc4mol
sterol-C4-methyl oxidase-like
chr10_-_99759658 0.308 ENSMUST00000056085.4
Csl
citrate synthase like
chr16_+_8830093 0.299 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr2_-_101621033 0.299 ENSMUST00000090513.4
B230118H07Rik
RIKEN cDNA B230118H07 gene
chr1_+_167618246 0.272 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chrX_+_152233228 0.247 ENSMUST00000112588.2
ENSMUST00000082177.6
Kdm5c

lysine (K)-specific demethylase 5C

chr11_-_70656467 0.245 ENSMUST00000131642.1
Gm12319
predicted gene 12319
chr5_-_121527186 0.244 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr2_-_73892619 0.244 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chr4_+_102760135 0.243 ENSMUST00000066824.7
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr6_-_99096196 0.240 ENSMUST00000175886.1
Foxp1
forkhead box P1
chr9_+_95637601 0.237 ENSMUST00000015498.8
Pcolce2
procollagen C-endopeptidase enhancer 2
chr11_-_109722214 0.233 ENSMUST00000020938.7
Fam20a
family with sequence similarity 20, member A
chr16_-_44139196 0.231 ENSMUST00000063661.6
ENSMUST00000114666.2
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr9_+_108392820 0.230 ENSMUST00000035234.4
1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr9_+_118506226 0.222 ENSMUST00000084820.4
Golga4
golgi autoantigen, golgin subfamily a, 4
chr2_-_73892588 0.220 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2


activating transcription factor 2


chr17_-_35910032 0.197 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
Atat1




alpha tubulin acetyltransferase 1




chr3_+_84925476 0.195 ENSMUST00000107675.1
Fbxw7
F-box and WD-40 domain protein 7
chr5_+_135187251 0.189 ENSMUST00000002825.5
Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr10_-_42478488 0.180 ENSMUST00000041024.8
Lace1
lactation elevated 1
chr18_-_15063560 0.179 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr1_+_182409162 0.174 ENSMUST00000117245.1
Trp53bp2
transformation related protein 53 binding protein 2
chr6_-_59024340 0.173 ENSMUST00000173193.1
Fam13a
family with sequence similarity 13, member A
chrX_-_48513518 0.171 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr1_-_63176653 0.168 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr9_-_64737684 0.167 ENSMUST00000171100.1
ENSMUST00000167569.1
ENSMUST00000004892.6
ENSMUST00000172298.1
Rab11a



RAB11a, member RAS oncogene family



chr7_-_141429433 0.165 ENSMUST00000124444.1
Cend1
cell cycle exit and neuronal differentiation 1
chr2_-_163417092 0.165 ENSMUST00000127038.1
Oser1
oxidative stress responsive serine rich 1
chr1_-_87573825 0.152 ENSMUST00000068681.5
Ngef
neuronal guanine nucleotide exchange factor
chr10_+_127078886 0.152 ENSMUST00000039259.6
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr14_-_30915387 0.147 ENSMUST00000166622.1
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr9_-_64737623 0.143 ENSMUST00000169058.1
Rab11a
RAB11a, member RAS oncogene family
chr17_-_35909626 0.140 ENSMUST00000141132.1
Atat1
alpha tubulin acetyltransferase 1
chr16_+_44139821 0.132 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr2_-_73892530 0.127 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2



activating transcription factor 2



chr13_-_17805093 0.122 ENSMUST00000042365.7
Cdk13
cyclin-dependent kinase 13
chr2_-_73911323 0.110 ENSMUST00000111996.1
ENSMUST00000018914.2
Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr10_-_93589621 0.107 ENSMUST00000020203.6
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr4_-_141623799 0.103 ENSMUST00000038661.7
Slc25a34
solute carrier family 25, member 34
chr7_-_141429351 0.095 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
Cend1


cell cycle exit and neuronal differentiation 1


chr2_-_26237368 0.091 ENSMUST00000036187.8
Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr4_-_42528175 0.087 ENSMUST00000180201.1
Gm13298
predicted gene 13298
chr2_+_61593125 0.086 ENSMUST00000112494.1
Tank
TRAF family member-associated Nf-kappa B activator
chr6_-_59024470 0.084 ENSMUST00000089860.5
Fam13a
family with sequence similarity 13, member A
chr10_+_53337686 0.083 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban

chr19_-_6921753 0.068 ENSMUST00000173635.1
Esrra
estrogen related receptor, alpha
chr11_+_70023905 0.068 ENSMUST00000124568.2
Dlg4
discs, large homolog 4 (Drosophila)
chr10_+_42502197 0.067 ENSMUST00000105499.1
Snx3
sorting nexin 3
chr18_+_36664060 0.066 ENSMUST00000036765.7
Eif4ebp3
eukaryotic translation initiation factor 4E binding protein 3
chr2_-_165283599 0.066 ENSMUST00000155289.1
Slc35c2
solute carrier family 35, member C2
chr10_-_40302186 0.055 ENSMUST00000099945.4
Amd1
S-adenosylmethionine decarboxylase 1
chr16_-_44139630 0.049 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr6_+_48613180 0.048 ENSMUST00000061720.4
Zfp775
zinc finger protein 775
chrX_+_7579666 0.042 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chr2_+_129065934 0.039 ENSMUST00000035812.7
Ttl
tubulin tyrosine ligase
chr10_+_93589413 0.038 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr19_+_46152505 0.033 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr1_-_191907527 0.016 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr5_+_30232581 0.011 ENSMUST00000145167.1
Ept1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr11_+_3650253 0.010 ENSMUST00000096441.3
Morc2a
microrchidia 2A
chr10_-_35711891 0.008 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr4_+_99955715 0.001 ENSMUST00000102783.4
Pgm2
phosphoglucomutase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.2 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.2 0.5 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 2.0 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 0.4 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) hematopoietic stem cell migration(GO:0035701) regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.4 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 0.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 0.3 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.1 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 2.0 GO:0010107 potassium ion import(GO:0010107)
0.1 1.1 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.1 0.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.6 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.6 GO:0032306 regulation of prostaglandin secretion(GO:0032306) embryonic process involved in female pregnancy(GO:0060136)
0.1 2.1 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 0.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 4.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 1.2 GO:0014047 glutamate secretion(GO:0014047)
0.0 1.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.5 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.2 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.4 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.2 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.0 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.6 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 0.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.4 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.5 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.0 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.5 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.9 GO:0043507 positive regulation of JUN kinase activity(GO:0043507)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:0042627 chylomicron(GO:0042627)
0.0 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 1.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.8 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 2.1 GO:0005875 microtubule associated complex(GO:0005875)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296) receptor agonist activity(GO:0048018)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808)
0.0 0.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.2 GO:0030546 receptor activator activity(GO:0030546)
0.0 0.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)