Motif ID: Nr4a2

Z-value: 0.568


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57124003_571240710.693.0e-04Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 107 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 5.497 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr18_+_86711059 3.316 ENSMUST00000068423.3
 Cbln2
cerebellin 2 precursor protein
chr2_+_121295437 2.078 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr13_+_94875600 1.989 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr9_-_32344237 1.975 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr2_-_129699833 1.401 ENSMUST00000028883.5
 Pdyn
prodynorphin
chr9_-_106656081 1.206 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr17_+_29360923 0.935 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr11_-_100822525 0.912 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr4_-_36136463 0.808 ENSMUST00000098151.2
 Lingo2
leucine rich repeat and Ig domain containing 2
chr2_+_75832168 0.640 ENSMUST00000047232.7
ENSMUST00000111952.2
 Agps

alkylglycerone phosphate synthase

chr1_+_57845534 0.635 ENSMUST00000169772.1
 Spats2l
spermatogenesis associated, serine-rich 2-like
chrX_-_142390334 0.626 ENSMUST00000112907.1
 Acsl4
acyl-CoA synthetase long-chain family member 4
chr18_-_56975333 0.619 ENSMUST00000139243.2
ENSMUST00000025488.8
 C330018D20Rik

RIKEN cDNA C330018D20 gene

chr8_+_70863127 0.613 ENSMUST00000050921.2
 A230052G05Rik
RIKEN cDNA A230052G05 gene
chr13_+_93304066 0.598 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr5_+_150259922 0.573 ENSMUST00000087204.5
 Fry
furry homolog (Drosophila)
chr2_+_4976113 0.532 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr10_+_94147982 0.524 ENSMUST00000105290.2
 Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr1_+_131910458 0.515 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.1 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 2.0 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 2.0 GO:0010107 potassium ion import(GO:0010107)
0.0 1.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.2 GO:0014047 glutamate secretion(GO:0014047)
0.1 1.1 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.3 0.9 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.0 0.9 GO:0043507 positive regulation of JUN kinase activity(GO:0043507)
0.1 0.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.6 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.6 GO:0032306 regulation of prostaglandin secretion(GO:0032306) embryonic process involved in female pregnancy(GO:0060136)
0.0 0.6 GO:0097320 membrane tubulation(GO:0097320)
0.2 0.5 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.5 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.5 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.5 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.9 GO:0030315 T-tubule(GO:0030315)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.3 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.3 GO:0042627 chylomicron(GO:0042627)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.4 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296) receptor agonist activity(GO:0048018)
0.0 0.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.1 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)