Motif ID: Nrf1

Z-value: 2.594


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.491.7e-02Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_88751649 6.936 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr10_+_79682304 6.925 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr13_-_53286052 5.013 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr10_+_79682169 4.429 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr2_+_168081004 4.161 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr3_-_125938537 3.745 ENSMUST00000057944.7
 Ugt8a
UDP galactosyltransferase 8A
chr12_+_16810940 3.644 ENSMUST00000020908.7
 E2f6
E2F transcription factor 6
chr5_+_36484578 3.219 ENSMUST00000060100.1
 Ccdc96
coiled-coil domain containing 96
chr11_+_40733936 3.153 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chr15_+_84923383 3.094 ENSMUST00000165443.2
 Nup50
nucleoporin 50
chr11_+_78094660 3.062 ENSMUST00000073705.5
 Fam222b
family with sequence similarity 222, member B
chr11_+_117115195 3.037 ENSMUST00000103026.3
ENSMUST00000090433.5
 Sec14l1

SEC14-like 1 (S. cerevisiae)

chr11_+_40733639 3.017 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr12_-_112511136 2.989 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr4_+_59581563 2.985 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr12_+_112146187 2.978 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr19_+_41911851 2.953 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr8_-_9976294 2.946 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr11_+_78094682 2.938 ENSMUST00000100782.3
 Fam222b
family with sequence similarity 222, member B
chr4_+_59581645 2.919 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 540 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.3 7.2 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 6.4 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.6 6.2 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
1.4 5.8 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.6 5.3 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
1.3 5.0 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.1 4.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.7 4.5 GO:1904667 negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.7 4.5 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.7 4.2 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.8 4.0 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223)
0.0 4.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.3 3.8 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.1 3.8 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
1.2 3.7 GO:0009812 flavonoid metabolic process(GO:0009812) flavonoid biosynthetic process(GO:0009813) flavonoid glucuronidation(GO:0052696)
0.2 3.7 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 3.7 GO:0000910 cytokinesis(GO:0000910)
0.3 3.6 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.2 3.6 GO:0097284 hepatocyte apoptotic process(GO:0097284)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.9 GO:0000776 kinetochore(GO:0000776)
0.0 8.1 GO:0060076 excitatory synapse(GO:0060076)
0.0 7.2 GO:0005874 microtubule(GO:0005874)
0.1 5.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 5.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 5.3 GO:0016235 aggresome(GO:0016235)
0.0 5.2 GO:0043296 apical junction complex(GO:0043296)
0.5 4.8 GO:0005642 annulate lamellae(GO:0005642)
0.4 4.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 4.6 GO:0090544 BAF-type complex(GO:0090544)
0.1 4.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 4.4 GO:0000242 pericentriolar material(GO:0000242)
0.8 4.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.3 4.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 3.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.4 3.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 3.7 GO:0005643 nuclear pore(GO:0005643)
0.6 3.6 GO:0005726 perichromatin fibrils(GO:0005726)
1.1 3.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 3.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 337 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.9 9.7 GO:0030957 Tat protein binding(GO:0030957)
0.1 9.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 8.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 8.1 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.5 7.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.6 7.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 7.1 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 6.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 5.5 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.2 5.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 5.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 5.1 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.2 4.9 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.8 4.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 4.5 GO:0003779 actin binding(GO:0003779)
0.1 4.3 GO:0003684 damaged DNA binding(GO:0003684)
0.6 4.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 4.1 GO:0050699 WW domain binding(GO:0050699)
0.6 3.7 GO:1990050 phosphatidic acid transporter activity(GO:1990050)