Motif ID: Onecut1_Cux2

Z-value: 1.273

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux2mm10_v2_chr5_-_122049822_122049882-0.844.7e-07Click!
Onecut1mm10_v2_chr9_+_74861888_748619210.658.1e-04Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Showing 1 to 20 of 98 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 28.738 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr6_+_4755327 12.481 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr14_+_68083853 12.028 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr3_+_102010138 9.134 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr10_-_64090241 4.667 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 4.548 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr8_+_58911755 4.201 ENSMUST00000062978.6
 BC030500
cDNA sequence BC030500
chr12_+_72441933 4.060 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr1_-_158958367 4.019 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr3_+_125404072 3.811 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr4_+_62965560 3.570 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr7_+_35802593 3.464 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr3_+_125404292 3.455 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr8_-_58911627 3.269 ENSMUST00000077447.4
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chrX_+_134404780 3.187 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr12_+_72441852 3.002 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chrX_+_134404543 2.850 ENSMUST00000113228.1
ENSMUST00000153424.1
 Drp2

dystrophin related protein 2

chr12_+_55598917 2.843 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr2_-_72986716 2.722 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chrX_-_43274786 2.453 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 28.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 12.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
4.0 12.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 9.2 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.3 9.1 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.7 3.4 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.6 3.4 GO:0003383 apical constriction(GO:0003383)
0.0 2.9 GO:0060349 bone morphogenesis(GO:0060349)
0.1 2.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 2.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.3 2.3 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.3 2.2 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.7 2.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 1.8 GO:0031507 heterochromatin assembly(GO:0031507)
0.6 1.7 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.5 1.5 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2 1.5 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 1.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 1.2 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 12.0 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 7.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 3.4 GO:0033269 internode region of axon(GO:0033269)
0.3 3.4 GO:0032584 growth cone membrane(GO:0032584)
0.0 2.7 GO:0000792 heterochromatin(GO:0000792)
0.6 2.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 1.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.4 GO:0010369 chromocenter(GO:0010369)
0.1 0.9 GO:0045298 tubulin complex(GO:0045298)
0.1 0.8 GO:0042587 glycogen granule(GO:0042587)
0.1 0.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 15.9 GO:0008270 zinc ion binding(GO:0008270)
0.5 12.0 GO:0043274 phospholipase binding(GO:0043274)
0.1 9.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 9.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.0 7.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 4.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 3.4 GO:0005042 netrin receptor activity(GO:0005042)
0.1 3.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 3.3 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.0 2.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.4 2.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.5 2.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 2.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 2.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.4 1.5 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 1.5 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 1.4 GO:0070491 repressing transcription factor binding(GO:0070491)