Motif ID: Otx1

Z-value: 0.347


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.154.9e-01Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_46818749 0.814 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr2_-_60963192 0.710 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr10_+_123264076 0.588 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr17_-_50094277 0.514 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr15_-_74734313 0.494 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr14_-_87141206 0.494 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr18_+_86711520 0.416 ENSMUST00000122464.1
 Cbln2
cerebellin 2 precursor protein
chr13_-_60897439 0.386 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr14_-_87141114 0.366 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr3_+_54481429 0.345 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr1_-_165708088 0.339 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr16_-_59632520 0.321 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chr9_+_108479849 0.317 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr1_+_131910458 0.312 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr12_+_103434211 0.291 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr19_+_4097392 0.289 ENSMUST00000174514.1
ENSMUST00000174149.1
 Cdk2ap2

CDK2-associated protein 2

chr7_-_83550258 0.276 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chrX_-_167209149 0.275 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr11_-_116694802 0.253 ENSMUST00000079545.5
 St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr11_+_100545607 0.242 ENSMUST00000092684.5
ENSMUST00000006976.7
 Ttc25

tetratricopeptide repeat domain 25


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 0.3 GO:0046909 intermembrane transport(GO:0046909)
0.1 0.3 GO:0097503 sialylation(GO:0097503)
0.0 0.3 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.3 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438) membrane fission(GO:0090148) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 0.1 GO:0002295 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0002036 regulation of L-glutamate transport(GO:0002036) endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.3 GO:0043256 laminin complex(GO:0043256)
0.0 0.3 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 GO:0008932 lytic endotransglycosylase activity(GO:0008932)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.1 0.2 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.1 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)