Motif ID: Otx1

Z-value: 0.347


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.154.9e-01Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_46818749 0.814 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr2_-_60963192 0.710 ENSMUST00000028347.6
Rbms1
RNA binding motif, single stranded interacting protein 1
chr10_+_123264076 0.588 ENSMUST00000050756.7
Fam19a2
family with sequence similarity 19, member A2
chr17_-_50094277 0.514 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chr15_-_74734313 0.494 ENSMUST00000023260.3
Lypd2
Ly6/Plaur domain containing 2
chr14_-_87141206 0.494 ENSMUST00000022599.7
Diap3
diaphanous homolog 3 (Drosophila)
chr18_+_86711520 0.416 ENSMUST00000122464.1
Cbln2
cerebellin 2 precursor protein
chr13_-_60897439 0.386 ENSMUST00000171347.1
ENSMUST00000021884.8
Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr14_-_87141114 0.366 ENSMUST00000168889.1
Diap3
diaphanous homolog 3 (Drosophila)
chr3_+_54481429 0.345 ENSMUST00000091130.3
Gm5641
predicted gene 5641
chr1_-_165708088 0.339 ENSMUST00000040357.8
ENSMUST00000097474.3
Rcsd1

RCSD domain containing 1

chr16_-_59632520 0.321 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr9_+_108479849 0.317 ENSMUST00000065014.4
Lamb2
laminin, beta 2
chr1_+_131910458 0.312 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr12_+_103434211 0.291 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
Ifi27





interferon, alpha-inducible protein 27





chr19_+_4097392 0.289 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr7_-_83550258 0.276 ENSMUST00000177929.1
Gm10610
predicted gene 10610
chrX_-_167209149 0.275 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr11_-_116694802 0.253 ENSMUST00000079545.5
St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr11_+_100545607 0.242 ENSMUST00000092684.5
ENSMUST00000006976.7
Ttc25

tetratricopeptide repeat domain 25

chr2_-_151980135 0.237 ENSMUST00000062047.5
Fam110a
family with sequence similarity 110, member A
chr4_-_41517326 0.233 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr9_+_68653761 0.216 ENSMUST00000034766.7
Rora
RAR-related orphan receptor alpha
chr9_-_109082372 0.212 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr8_-_47675556 0.207 ENSMUST00000125536.1
Ing2
inhibitor of growth family, member 2
chr17_+_35861318 0.206 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chrM_+_10167 0.205 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr5_-_100373484 0.197 ENSMUST00000182433.1
Sec31a
Sec31 homolog A (S. cerevisiae)
chr5_-_104456467 0.177 ENSMUST00000069263.4
Gm10047
predicted gene 10047
chr7_-_38271310 0.172 ENSMUST00000032585.6
Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr13_-_21750505 0.165 ENSMUST00000102983.1
Hist1h4k
histone cluster 1, H4k
chr5_-_37336870 0.158 ENSMUST00000031005.4
Evc
Ellis van Creveld gene syndrome
chr2_+_154656959 0.154 ENSMUST00000044277.9
Chmp4b
charged multivesicular body protein 4B
chr14_+_105258673 0.148 ENSMUST00000136040.2
Ndfip2
Nedd4 family interacting protein 2
chr7_-_118129567 0.143 ENSMUST00000032888.7
Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr3_-_105960099 0.138 ENSMUST00000118209.1
Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr10_+_3973086 0.137 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr13_+_21180179 0.131 ENSMUST00000021761.5
Trim27
tripartite motif-containing 27
chr13_+_21495218 0.126 ENSMUST00000104942.1
AK157302
cDNA sequence AK157302
chr10_-_93889758 0.120 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
Metap2



methionine aminopeptidase 2



chr4_-_42661893 0.119 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr13_+_104178797 0.114 ENSMUST00000022225.5
ENSMUST00000069187.5
Trim23

tripartite motif-containing 23

chr7_-_79848191 0.113 ENSMUST00000107392.1
Anpep
alanyl (membrane) aminopeptidase
chr15_-_79285502 0.110 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr17_+_35861343 0.109 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr13_+_21735055 0.107 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr2_-_156180135 0.102 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
Rbm39




RNA binding motif protein 39




chr11_+_78346666 0.101 ENSMUST00000100755.3
Unc119
unc-119 homolog (C. elegans)
chr8_-_54718664 0.095 ENSMUST00000144711.2
ENSMUST00000093510.2
Wdr17

WD repeat domain 17

chr13_+_90089705 0.095 ENSMUST00000012566.8
Tmem167
transmembrane protein 167
chrX_-_95956890 0.092 ENSMUST00000079987.6
ENSMUST00000113864.2
Las1l

LAS1-like (S. cerevisiae)

chr10_+_127642975 0.090 ENSMUST00000092074.5
ENSMUST00000120279.1
Stat6

signal transducer and activator of transcription 6

chr14_-_122913751 0.089 ENSMUST00000160401.1
Ggact
gamma-glutamylamine cyclotransferase
chr7_-_4063195 0.089 ENSMUST00000068865.5
ENSMUST00000086400.6
Lair1

leukocyte-associated Ig-like receptor 1

chr17_+_8165501 0.085 ENSMUST00000097419.3
ENSMUST00000024636.8
Fgfr1op

Fgfr1 oncogene partner

chr6_+_48589560 0.085 ENSMUST00000181661.1
Gm5111
predicted gene 5111
chr19_+_5689131 0.085 ENSMUST00000004156.8
Map3k11
mitogen-activated protein kinase kinase kinase 11
chr13_+_41016250 0.085 ENSMUST00000021790.5
Tmem14c
transmembrane protein 14C
chr11_+_94936224 0.084 ENSMUST00000001547.7
Col1a1
collagen, type I, alpha 1
chr7_-_100662315 0.083 ENSMUST00000151123.1
ENSMUST00000107047.2
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr6_-_136828186 0.082 ENSMUST00000116514.1
Wbp11
WW domain binding protein 11
chr9_-_66975387 0.077 ENSMUST00000034929.6
Lactb
lactamase, beta
chr3_+_66985647 0.077 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chrM_+_11734 0.076 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr1_-_24612700 0.072 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr14_+_29968308 0.071 ENSMUST00000112268.1
Selk
selenoprotein K
chr4_-_123750236 0.068 ENSMUST00000102636.3
Akirin1
akirin 1
chr7_-_100662414 0.066 ENSMUST00000079176.6
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr10_+_80054029 0.060 ENSMUST00000097227.3
Gpx4
glutathione peroxidase 4
chr3_+_66985947 0.057 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr11_+_115564434 0.056 ENSMUST00000021085.4
Nup85
nucleoporin 85
chr5_-_37336837 0.056 ENSMUST00000114148.1
Evc
Ellis van Creveld gene syndrome
chrX_+_37126777 0.055 ENSMUST00000016553.4
Nkap
NFKB activating protein
chr17_-_47611449 0.055 ENSMUST00000024783.8
Bysl
bystin-like
chr10_+_29313164 0.054 ENSMUST00000160399.1
Echdc1
enoyl Coenzyme A hydratase domain containing 1
chrX_-_48513518 0.053 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr13_-_92030897 0.053 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr13_-_55321928 0.048 ENSMUST00000035242.7
Rab24
RAB24, member RAS oncogene family
chr5_-_98566762 0.047 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr7_-_104950441 0.044 ENSMUST00000179862.1
Gm5900
predicted pseudogene 5900
chr14_-_54605908 0.044 ENSMUST00000022786.4
4931414P19Rik
RIKEN cDNA 4931414P19 gene
chr18_+_80206887 0.042 ENSMUST00000127234.1
Gm16286
predicted gene 16286
chr11_-_116274102 0.035 ENSMUST00000106425.3
Srp68
signal recognition particle 68
chr2_-_11603192 0.034 ENSMUST00000040314.5
Rbm17
RNA binding motif protein 17
chr2_+_177897096 0.032 ENSMUST00000108935.1
Gm14327
predicted gene 14327
chr6_-_29507946 0.031 ENSMUST00000101614.3
ENSMUST00000078112.6
Kcp

kielin/chordin-like protein

chr19_-_6057736 0.029 ENSMUST00000007482.6
Mrpl49
mitochondrial ribosomal protein L49
chr10_+_61648552 0.025 ENSMUST00000020286.6
Ppa1
pyrophosphatase (inorganic) 1
chr1_-_118311132 0.021 ENSMUST00000027623.7
Tsn
translin
chr5_-_5749317 0.016 ENSMUST00000015796.2
Steap1
six transmembrane epithelial antigen of the prostate 1
chr2_-_144011202 0.014 ENSMUST00000016072.5
ENSMUST00000037875.5
Rrbp1

ribosome binding protein 1

chr19_-_7039987 0.009 ENSMUST00000025918.7
Stip1
stress-induced phosphoprotein 1
chr19_+_41933464 0.007 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr11_-_116274197 0.005 ENSMUST00000021133.9
Srp68
signal recognition particle 68
chr10_-_88605017 0.002 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.1 GO:0002295 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373)
0.1 0.3 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 0.3 GO:0046909 intermembrane transport(GO:0046909)
0.1 0.3 GO:0097503 sialylation(GO:0097503)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.3 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438) membrane fission(GO:0090148) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0002036 regulation of L-glutamate transport(GO:0002036) endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.3 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.1 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.1 GO:0071639 positive regulation of monocyte chemotactic protein-1 production(GO:0071639)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.3 GO:0043256 laminin complex(GO:0043256)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.1 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.3 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.1 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.3 GO:0008932 lytic endotransglycosylase activity(GO:0008932)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)